The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Program on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix and a glossary of terms is also provided.
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The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
active chemical moiety, toxicodynamic data, appropriate toxicokinetic parameter, acetic acid metabolite, default uncertainty factor, active acid metabolite, composite uncertainty factor, critical toxic effect, inhibited indicate, active chemical entity, interspecies factor, toxicokinetic data, human variability, parent chemical, testicular toxicity, following oral exposure, plasma haemoglobin, haematological effects, interspecies differences, susceptible subgroups, default factor, appropriate study design, alcohol metabolite, microsomal protein, internal dose New!
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The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
active chemical moiety, toxicodynamic data, appropriate toxicokinetic parameter, acetic acid metabolite, default uncertainty factor, active acid metabolite, composite uncertainty factor, critical toxic effect, inhibited indicate, active chemical entity, interspecies factor, toxicokinetic data, human variability, parent chemical, testicular toxicity, following oral exposure, plasma haemoglobin, haematological effects, interspecies differences, susceptible subgroups, default factor, appropriate study design, alcohol metabolite, microsomal protein, internal dose New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
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