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Chemistry and Molecular Aspects of Drug Design and Action
 
 
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Chemistry and Molecular Aspects of Drug Design and Action [Hardcover]

E. A. Rekka (Editor), P. N. Kourounakis (Editor)

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Book Description

0849390060 978-0849390067 April 28, 2008 1
An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds.

Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks.

Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest.

  • Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions
  • Classical Medicinal Chemistry
  • Drug Design, Chemical and Molecular Aspects of Drug Action
  • Drug Xenobiotic Metabolism
  • Physical Organic and Theoretical Medicinal Chemistry
  • While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to build on current progress.


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    Inside This Book (learn more)
    Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
    recognition site, thiocarboxanilide derivatives, recombinatorial chemistry, hemorrhagic mucosal lesions, oxathiin carboxanilide, knockout concentrations, duodenal ulcerogen cysteamine, human aldosterone synthase, virus breakthrough, colonic motor function, mast cell secretion, gastroprotective effect, locked nucleic acid, chronic duodenal ulcers, tertiary compounds, nitrenium ion, duodenal ulcer healing, factor acetylhydrolase, early drug discovery, pharmacophore model, cannabinoid receptors, oxidized phospholipids, thiazole derivatives, gastric mucosal injury
    Key Phrases - Capitalized Phrases (CAPs): (learn more)
    Brain Res, Drug Metab, Free Radic, The Fight Against, Drug Res, New York, Cell Biol, Agents Chemother, Cancer Res, Trends Pharmacol, Life Sci, Medicinal Chemistry of Cannabinoids, Liver Physiol, Anti-Inflammatory Structure of Flavonoids, Boca Raton, Trends Neurosci, John Wiley, Antiviral Res, Synthesis of Biologically Active Taxoids, Steroid Biochem, Academic Press, Hans Selye, The Effect of Diet, Naunyn-Schmiedeberg's Arch, New Prognostic Factor
    Browse Sample Pages:
    Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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