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Chirality in Industry II: Developments in the Commercial Manufacture and Applications of Optically Active Compounds
  
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Chirality in Industry II: Developments in the Commercial Manufacture and Applications of Optically Active Compounds [Hardcover]

A. N. Collins (Editor), Gary Sheldrake (Editor), J. Crosby (Editor)


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Book Description

0471966800 978-0471966807 February 1997 1
This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II
* All new case histories


* Unique industrial perspective on chiral technology


* Emphasis on scale-up and process development


* Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches
The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.

Editorial Reviews

From the Publisher

Chirality describes the pharmacological, biological, and chemical consequences of molecular symmetry. This book presents an industrial rather than academic approach to chirality, allowing readers to apply it to the manufacture and commercialization of optically active products. This second volume includes important case histories and expert views from regulatory bodies. It covers antiviral nucleosides, chiral liquid crystals, membrane technology for racemate separation and all aspects of the scale-up and manufacture of optically active intermediates and products.

From the Back Cover

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II
  • All new case histories

  • Unique industrial perspective on chiral technology

  • Emphasis on scale-up and process development

  • Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches
The ?chiral infrastructure? is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of ?chiral chemistry? depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of ?large-scale? thinking. An economic solution is still most likely to be a simple, elegant solution. --This text refers to the Paperback edition.

Product Details

  • Hardcover: 418 pages
  • Publisher: John Wiley & Sons; 1 edition (February 1997)
  • Language: English
  • ISBN-10: 0471966800
  • ISBN-13: 978-0471966807
  • Product Dimensions: 9.3 x 6.2 x 1.3 inches
  • Shipping Weight: 1.6 pounds
  • Amazon Best Sellers Rank: #10,620,367 in Books (See Top 100 in Books)

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Inside This Book (learn more)
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First Sentence:
In surveying developments since Volume I was published in 1992, it is clear that the needs of the pharmaceutical industry continue to be a major driving force for development of new and cost-effective methods for manufacturing optically active materials and, inevitably, much of the content of this volume is pharmaceutically oriented. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
ferroelectric dopants, profen drugs, situ racemisation, asymmetric hydrocyanation, soluble diastereoisomer, active glycidol, racemate crystallises, hydrocyanation reaction, titanium tartrate catalyst, prochiral sulphides, epoxy alcohol product, cyclic phosphoric acids, optical purification, active epoxy alcohols, diastereoisomeric salts, glycidol derivatives, enantioselective protonation, direct crystallisation, metastable zone, selective crystallisation, melting point phase diagram, conglomerate crystals, dehalogenase activity, single chiral centre, electronic asymmetry
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Tetrahedron Lett, New York, John Wiley, Sons Ltd, Perkin Trans, Spring Innovations, Analgesic Associates, Eur Pat, Zambon Group, Glaxo Wellcome, Marcel Dekker, Ministry of Defence, Proceedings of Chiral, Tetrahedron Left, Angew Chem, Chiral Reactions, Drugs Future, Eng News, Ethyl Corp, Nippon Petrochemicals, Organism Conversion, Red Trav, Temperature Figure, Union Carbide, Academic Press
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