Chromosomal Translocations and Oncogenic Transcription Factors [Hardcover]

Frank J. III Rauscher (Editor), Peter K. Vogt (Editor)

Book Description

Series: Current Topics in Microbiology and Immunology | Publication Date: April 15, 1997

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.

Product Details

• Hardcover: 166 pages
• Publisher: Springer; 1 edition (April 15, 1997)
• Language: English
• ISBN-10: 3540614028
• ISBN-13: 978-3540614029
• Product Dimensions: 9.8 x 6.5 x 0.5 inches
• Shipping Weight: 13.9 ounces
• Amazon Best Sellers Rank: #10,272,245 in Books (See Top 100 in Books)