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Clinical Cancer Genetics: Risk Counseling and Management
 
 
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Clinical Cancer Genetics: Risk Counseling and Management [Hardcover]

Kenneth Offit (Author)

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Book Description

0471146552 978-0471146551 January 2, 1998 1
With a Foreword by Richard D. Klausner, M.D., Director, National Cancer Institute and an Introduction by Henry T. Lynch, M.D., President, Hereditary Cancer Institute and Director, Creighton Cancer Center, Creighton University.

When ordering a genetic test to determine whether a patient is susceptible to genetically transmitted cancers, physicians must be prepared to cope with profound medical, psychological, and ethical consequences. They, along with genetic counselors, nurses, psychologists, and other health professionals, must ensure that interpretations of test results are accurate, risk assessments are appropriate, and the communication of risk information is clear, helpful, and productive.

Clinical Cancer Genetics: Risk Counseling and Management is a comprehensive practical guide for health professionals responding to the growing demand for clinical cancer genetic services. Using examples drawn from actual cases and emphasizing fundamental principles throughout, this book outlines the scope of clinical cancer genetics and its underlying scientific concepts, reviews the most prevalent syndromes of cancer predisposition, and addresses major issues associated with genetic testing, including:
* Use of quantitative methods in risk counseling
* Methodologies of genetic testing
* Genetic testing of patients with cancer
* Reproductive risk counseling of cancer patients
* Special psychological, ethical, and legal challenges in clinical cancer genetics

Supplemented with practical materials used in cancer genetic counseling programs and an annotated table of selected human cancer predisposition syndromes, Clinical Cancer Genetics: Risk Counseling and Management equips health care professionals with a complete understanding of the benefits and limitations of genetic testing technologies and the ability to integrate genetic information into the management of patients who are at risk or already affected by cancer.

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Editorial Reviews

From The New England Journal of Medicine

Dr. Offit's book on cancer genetics in clinical practice covers most of the essential material in this complex field in a highly effective and readable way. The role of genetics in cancer is put into context by a superb overview of the role of genetics in disease, and Offit reviews our current knowledge of specific forms of genetic predisposition in both common and rare cancers. Using this information, he is able to discuss the difficult aspects of applying this knowledge in the clinic, providing case histories to help illustrate problems. The chapter on quantitative risk assessment gives an excellent overview of how risk can be evaluated and expressed. In the final chapter, Dr. Offit tackles a "soft" but important component of cancer genetics in clinical practice: the psychology and ethics of counseling. This discussion inevitably contrasts with the scientific rigor of the rest of the book, but the importance of this component is made obvious and highlights the need for careful evaluation of counseling activities.

Two important aspects of this field receive little attention. Few doubt the impact that genes of relatively small effect will have on the field, particularly loci that have high-frequency, low-penetrance alleles and that interact with other genetic or environmental factors to contribute to the disease. In the future, it will be important to consider how to deal with such genetic effects that confer risks more relevant to populations than to individuals. The role of polymorphisms of genes involved in drug metabolism or responses is also not emphasized, although this is also a problem for the future.

This book summarizes the current state of cancer genetics in clinical practice and effectively captures the excitement in this fast-moving field. It clearly demonstrates how genetics can now be applied to clinical oncology and is a harbinger of things to come for all areas of medical practice.

Reviewed by John Bell, D.M.

Review

"I refer to [this book] frequently and almost feel as if Dr. Offit was in the consulting room. I urge oncologists and other professionals providing cancer risk counseling to read this book and keep it at hand for convenient reference." --Annals of Oncology

"This is an excellent textbook ...it will be on my list of recommended reading for students...." (Human Genetics, May 2000)

"This is an excellent textbook encompassing a wealth of experience." (Human Genetics, No. 106, 2000)

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Inside This Book (learn more)
First Sentence:
In his epic history of human knowledge, Charles Van Doren (1992) observed that there have been two periods of cataclysmic expansion of human understanding. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
clinical cancer genetics, nonpolyposis colon cancer syndrome, cancer risk counseling, cancer genetic counseling, sebaceous skin tumors, gonadal germ cell tumors, inherited cancer risk, component tumors, myocardial rhabdomyoma, cancer predisposition genes, cancer genetic testing, vitro synthesized protein assay, common adult cancers, cancer predisposition syndromes, cancer kindreds, ovarian cancer families, summary relative risk, cardiac fibroma, duodenal carcinoid, familial colon cancer, hereditary cancer syndromes, ovarian cancer risk, familial pheochromocytoma, predisposition testing, sertoli cell tumor
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Nature Genet, New Engl, Natl Cancer Inst, New York, United States, Ashkenazi Jewish, Clin Oncol, Ashkenazi Jews, Ann Intern Med, Med Genet, National Institutes of Health, Proc Natl Acad Sci, Health Study, Hum Molec Genet, Nature Medicine, Obstet Gynecol, Arch Intern Med, Gilda Radner, American Cancer Society, Oxford University Press, Cancer Genet Cytogenet, Dis Colon Rectum, Hum Mol Genet, Institute of Medicine
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