Industrial-Sized Deals Shop all Back to School Shop Men's Hightops Learn more nav_sap_plcc_6M_fly_beacon Cecile McLorin Salvant UP3 $5 Off Fire TV Stick Subscribe & Save Shop Popular Services hog hog hog  Amazon Echo Starting at $99 Kindle Voyage Labor Day Savings with Amazon Outdoor Recreation Learn more
Buy Used
Condition: Used: Very Good
Comment: A well-cared-for item that has seen limited use but remains in great condition. The item is complete, unmarked, and undamaged, but may show some limited signs of wear. Item works perfectly.
Have one to sell? Sell on Amazon
Flip to back Flip to front
Listen Playing... Paused   You're listening to a sample of the Audible audio edition.
Learn more
See this image

The Clinical and Scientific Basis of Myalgic Encephalomyelitis--Chronic Fatigue Syndrome Hardcover – July, 1992

9 customer reviews

See all formats and editions Hide other formats and editions
Amazon Price New from Used from
"Please retry"
$47.95 $6.47

New & Popular:"The Brain Fog Fix"
Read the popular new book by Mike Dow.

Editorial Reviews


"...this is a comprehensive volume of current knowledge on CFS...this book will serve to better understand this misunderstood entity. " -- Javier Villanueva-Meyer, MD, The University of Texas Medical Branch at Galveston.

"It is a remarkable work. It is a very important achievement in the field of CFS..." -- J. Prieto, MD, Clinica Universitaria, Facultad de Medicina, Spain.

"It is a very impressive volume in both style and content. I very much enjoy the work and am pleased to be able to add it to my library." -- Alfredo A. Sadun, MD, PhD, Professor, University of Southern California School of Medicine.

"It is an impressive volume! It is very beautifully printed, well-organized and tastefully done." -- Seymour Grufferman, MD, PhD, Professor and Chairman, University of Pittsburgh

"It is an outstanding volume both for content and aspect. I am sure it will become a milestone in the scientific history of the disease." -- Mauro Bendinelli, MD, PhD, Professor and Chairman, Universita di Pisa, Dipartimento Di Biomedicina, Italy.

"Let me again stress that I am very pleased with your book and your excellent addendum on Dr. Sigurdsson. " -- Gudmundur Petursson, Institute for Experimental Pathology, University of Iceland.

"Let me offer you both thanks and congratulations on a comprehensive work well done; a medical book with a human face." -- Professor C. R. Boughton, The Prince of Henry Hospital, Australia.

"We believe you have done CFS sufferers a service worldwide with this book...As a vehicle for raising public awareness and stimulating debate, we can hardly imagine anything more provocative." -- John Cross, PhD, University of Otago, Department of Microbiology, New Zealand.

The Nightingale Research Foundation "has broken new ground in compiling and editing a broad range of information about one of the most devastating of all chronic illnesses, braving the Zeitgeist by presenting ideas not only from the common wisdom of traditional medicine and research, but also from the worthy individuals in step with other drummers. The scope of your text is far-ranging and you leave no stone, no virus, unturned. The book is, to say the least, provocative and I'm sure that it will serve to stimulate researchers around the world to accept the challenge you have set before them. But most of all, your text will give new hope to many patients that finally the medical community is beginning to take this illness seriously. -- Walter J. Gunn, PhD, President, Arlington Associates Inc., and former Center for Disease Control, Atlanta, Principal Investigator for Chronic Fatigue Syndrome Studies.

About the Author

Dr. Byron M. Hyde is founder and chairman of The Nightingale Research Foundation, a charitable organization located in Ottawa, Canada dedicated to conduct and assist research into the cause and cure of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (M.E./CFS).

Dr. Byron Hyde attended the Haileybury School of Mines and worked as a geophysicist. He then did pre-medicine in the Faculty of Medicine and University College, University of Toronto, obtaining a degree in chemistry and nutrition. He graduated in medicine from the University of Ottawa where he was the Director and Chief of the International Exchange Program for the Canadian Association of Medical Students and Interns (CAMSI). Dr. Hyde founded the International Summer School in Tropical Medicine. He interned at Hotel Dieu in Montreal, was a resident at St. Justine Hospital in Montreal and at the Ottawa Civic Hospital. He also studied in Munich at the University Kinderklinik and in Paris at the Necker Hospital for Children.

He was a research chemist at the Roscoe B. Jackson Laboratory at Bar Harbour, Maine, a leading world laboratory in immunological research. Following this, he was Chief Technician in charge of the Electron Microscope Laboratory in Toronto at the Hospital for Sick Children, followed by a similar post at the University of British Columbia.

Dr. Hyde has authored a book on Electron Microscopy and two non-medical books. Dr. Hyde has been a physician for 32 years and has performed charitable work as a physician in Laos and the Caribbean. He held the position of Chairman of the Ottawa Community Health Services Association, and is presently Chairman of The Nightingale Research Foundation.

In 1984, Dr. Hyde began the full-time study of the disease process then known as Myalgic Encephalomyelitis (renamed in 1986 by Dr. Gary Holmes in the USA to Chronic Fatigue Syndrome). He has worked exclusively with M.E./CFS patients since 1985. In 1988, Dr. Hyde organized an association and founded The Nightingale Research Foundation, dedicated to the study of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome. He has also acted as Chairman of the 1990 Cambridge Easter Symposium and of the Workshop on Canadian Research Directions for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome in May, 1991, at the University of British Columbia.


Best Books of the Month
Best Books of the Month
Want to know our Editors' picks for the best books of the month? Browse Best Books of the Month, featuring our favorite new books in more than a dozen categories.

Product Details

  • Hardcover: 724 pages
  • Publisher: Nightingale Research Fndtn (July 1992)
  • Language: English
  • ISBN-10: 0969566204
  • ISBN-13: 978-0969566205
  • Product Dimensions: 1.5 x 9 x 11.5 inches
  • Shipping Weight: 4.2 pounds
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (9 customer reviews)
  • Amazon Best Sellers Rank: #934,393 in Books (See Top 100 in Books)

Customer Reviews

5 star
4 star
3 star
2 star
1 star
See all 9 customer reviews
Share your thoughts with other customers

Most Helpful Customer Reviews

11 of 11 people found the following review helpful By Jodi-Hummingbird on December 31, 2007
Format: Hardcover Verified Purchase
An excellent resource from Dr Byron Hyde MD (editor).

This book is the one and only M.E. textbook. This book is essential reading for anyone with M.E., or an interest in M.E. Buy this book!!!

Not all of the many chapters in this book are worthwhile or still current, BUT this book is well worth the price and the 5 stars even if only for the five or six chapters written by Dr Hyde, unarguably the world's leading M.E. expert.

I'd also highly recommend you check out Dr Hyde's more recent writings. I cannot recommend them highly enough.

As Dr Hyde explains, M.E. is not 'CFS.'

"At the first meeting on the 27th of October 2005, the Chairman of the
Joint Committee, Dr Ian Gibson, asked me to prepare a report and
definition that might assist the committee in its further deliberations.
The following are my original recommendation. Dr Bruce Carruthers, who
chaired the 2003 Canadian Clinical Case Definition for M.E./CFS, was
also present when I gave this definition. I strongly disagreed with Dr
Caruthers in the merging the definitions of M.E. and CFS since on the
basis of the physical total body assessment of both M.E. and CFS
patients; these two names represent two entirely different spectrums of
It is increasingly obvious that too much importance was being
placed upon the definitions of Chronic Fatigue Syndrome (CFS), and not
enough upon the actual disease, Myalgic Encephalomyelitis (M.E.). These
two illness spectrums are not the same and should not be considered to
be the same.
Read more ›
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
14 of 15 people found the following review helpful By Melissa Kaplan on January 30, 2001
Format: Hardcover
Shortly after I was diagnosed with CFS and FM by Jay Goldstein, MD, I attended a "CFS and the Brain" conference at which Byron Hyde and several other researchers who appear in this book's pages spoke and shared their research and questions. Nearly a decade later, much of the information in this book is still germane - and interesting, such as the historical recounting of epidemics through the years, brain imaging patterns, neurocognitive abnormalities and more.
If you aren't interested in this book for yourself, consider buying this book and donating it to your local public library or CFS/FM/MCS/ME or neuroimmune/autoimmune diseases support group so it can be read and learned from by those who are unable to afford it for themselves.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
11 of 12 people found the following review helpful By Daniel on April 22, 2004
Format: Hardcover
Unbelievably insightfull to those who have or are suffering
from this devestating disease process .Every treating physician
should have this in there office.In my personal observations
with some people I have met and also myself and my wife it is
definetly and as a matter of medical fact a potential lifesaver.
The fact that this author Dr. Byron Hyde has went to extreme
lenghts to study research and organise the world symposium
on this to gather varied medical research and facts from all
these brilliant minds tells me that this man deserves at the
very least a medal of Honour but rather the Nobel Peace Prize
for devoting at least 25 years of his life to studying and
caring enough to try and find the cause and cure of so much
human suffering that exists in our world. My sincerest regards...
P.S. I passed on the book to another fellow sufferer and never
really got the chance to read very much but my doctor has one now.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
5 of 5 people found the following review helpful By Boo Radley on September 22, 2009
Format: Hardcover
When you or someone you love is suddenly stricken with a serious illness, you want an experienced, knowledgeable doctor to be able to diagnose and treat you efficiently and with sympathy. Unfortunately this isn't always possible, and victims of poorly understood illness often have to fight for recognition and appropriate treatment. The only way to avoid getting lost in the healthcare system or, even worse, to find yourself participating in prescribed treatment programs that may do more harm than good, is to arm yourself with as much knowledge as you can.

The Nightingale Foundation is one of the few bodies dedicated to researching M.E. and disseminating useful information about the disease. It is also one of the few organisations to advocate the distinction between Myalgic Encephalomyelitis and what is commonly called Chronic Fatigue Syndrome - a crucial qualification. "The Clinical and Scientific Basis of Myalgic Encephalomyelitis--Chronic Fatigue Syndrome" is an unparalleled resource for patients and clinicians trying to understand this baffling illness. The Nightingale Foundation's ground-breaking definition of M.E. was drafted to quickly diagnose and effectively treat M.E. and also to "give comfort to M.E. patients everywhere." It seems like a large, intimidating reference book, but I can personally vouch for the comfort its been to me throughout my illness. Tested scientific facts are more reassuring than anything when you're ill and feel like you've been abandoned by the medical profession.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again
1 of 1 people found the following review helpful By Linda O'Brien on September 24, 2009
Format: Hardcover Verified Purchase
This book was an extensive compilation of the clinical work and research efforts of a great number of qualilfied medical doctors, from not only America but from around the world as well. From one who has suffered the effects of ME/CFS for a number of years...with time out for good behavior..I was dumbfounded that so much work and intense effort has been put in to the study and depth that was shown in this work.
It is very readable and well organized. The extensive index also helped with the specific information in question. I recommend it for medical personnel so that the patients who complain of ME/CFS will have a chance to make headway under your watch.

This book will help to take us out of the dark ages of marginalizing the ME/CFS sufferers and in to the realm of considering their needs and motivating adequate
care and healing modes.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback. If this review is inappropriate, please let us know.
Sorry, we failed to record your vote. Please try again

Want to discover more products? Check out this page to see more: fibromyalgia