This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience.
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This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience.
From the Back Cover
Clinical Trials A Practical Approach Stuart J. Pocock Professor of Medical Statistics and Director of Clinical Trials Research Group London School of Hygiene and Tropical Medicine, University of London, UK It is well recognized that randomized clinical trials play an important role in the evaluation of new treatments. However, the reliable achievement of genuine patient benefit depends on clinical trials being well organized and conducted according to proper ethical and scientific standards. This comprehensive text on the principles and practice of clinical trials gives a detailed account of how to conduct trials and also provides a general perspective on their historical development, current status and future strategy. Each aspect of clinical trial design, analysis and interpretation is described in a non-technical manner and illustrated by actual trials. In particular, relevant statistical methods are clearly explained for clinicians and others without statistical training. This book will be essential reading for clinicians, statisticians, medical students, the pharmaceutical industry and anyone wishing to acquire a true understanding of clinical trials. 'The purpose of this book is to explain in practical terms the basic principles of clinical trials. ... This book succeeds admirably in this aim and is accessible to a wide audience, including clinical investigators, statisticians, and those involved in data management and the administration of clinical trials.' Controlled Clinical Trials 'This book is an outstanding practical guide to the design, planning, execution and analysis of clinical trials.' Journal of the Royal Society of Medicine 'Pocock's book is a helpful and thoughtful one ... of considerable value to clinicians who are drawn into clinical trials.' The Lancet 'This is an excellent book ... which will be of value to anyone beginning work in the field of clinical trials, but at the same time it provides a useful reference work for those already experienced in clinical trials.' Trends in Pharmacological Sciences
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23 of 24 people found the following review helpful:
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Review of Clinical Trials: A practical approach,
By David R. Snydman, MD (Tufts University School of Medicine, Boston, Ma USA) - See all my reviews
This review is from: Clinical Trials: A Practical Approach (Hardcover)
I found this book almost 15 years ago when first designing a series of clinical trials for cytomegaovirus prevention in organ transplantation. It is a very practical "how to" volume, extremely well written and concise. I recommend this to all clinical investigators who are starting out, and for all trainees. I have been waiting for his revised edition for over a decade and only hope he will update this great book.
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Inside This Book
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First Sentence:
The evaluation of possible improvements in the treatment of disease has historically been an inefficient and haphazard process. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
continuous sequential designs, random permuted blocks within strata, unequal randomization, randomization list, ineligible patients, randomized consent design, random treatment assignment, trial organizers, lymphoma trial, clofibrate trial, comparable treatment groups, central registration office, metoprolol trial, patient accrual, haematologic toxicity, repeated significance testing, hypotensive treatment, percentage dying, group sequential designs, interim analyses, multiple logistic model, informed patient consent, group sequential methods, repeated significance tests, stratified randomization Key Phrases - Capitalized Phrases (CAPs): (learn more)
United States, Medical Research Council, Committee of Principal Investigators, National Cancer Institute, Safety of Medicines, United Kingdom, Eastern Cooperative Oncology Group New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
The evaluation of possible improvements in the treatment of disease has historically been an inefficient and haphazard process. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
continuous sequential designs, random permuted blocks within strata, unequal randomization, randomization list, ineligible patients, randomized consent design, random treatment assignment, trial organizers, lymphoma trial, clofibrate trial, comparable treatment groups, central registration office, metoprolol trial, patient accrual, haematologic toxicity, repeated significance testing, hypotensive treatment, percentage dying, group sequential designs, interim analyses, multiple logistic model, informed patient consent, group sequential methods, repeated significance tests, stratified randomization Key Phrases - Capitalized Phrases (CAPs): (learn more)
United States, Medical Research Council, Committee of Principal Investigators, National Cancer Institute, Safety of Medicines, United Kingdom, Eastern Cooperative Oncology Group New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 21
books:
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86
books
cite this book:
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- Medical Research Council: Sale of the Mount Vernon Site, Hampstead: [Hc]: [1994-95]: House of Commons Papers: [1994-95] by Great Britain on page 18, page 29, and page 136
- Clinical Trials by Author Unknown in Back Matter
- The Statistical Analysis of Failure Time Data (Wiley Series in Probability and Statistics) by John D. Kalbfleisch in Back Matter
- Nonparametric Statistics for The Behavioral Sciences by Sidney Siegel in Back Matter
- Effectiveness And Efficiency: Random Reflections on Health Services by A.L. Cochrane in Back Matter
See all 21 books this book cites
- Research Methods in Health: Investigating Health and Health Services by Ann Bowling on 5 pages
- Sample Size Tables for Clinical Studies (With 3 5 Inch Diskette for Windows 3 1 Or 95) by David Machin on 5 pages
- Research Methods in Health: Investigating Health and Health Services by Ann Bowling on 5 pages
- AIDS Clinical Trials by Dianne M. Finkelstein in Front Matter, page 89, and page 102
- Medical Statistics at a Glance by Aviva Petrie in Front Matter, and page 34
See all 86 books citing this book
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