Coalescent theory provides the foundation for molecular population genetics and genomics. It is the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data. This monograph is intended mainly for biologists but it will also be of interest to mathematicians who wish to see how this branch of applied probability theory plays out in a biological setting.
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Editorial Reviews
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"I'm thrilled Wakeley is writing this book. For those excited to learn about the coalescent, this is a godsend." --Ben Kerr, University of Washington<br /><br />"Wakeley's book is clearly written and takes time to explain things." --Richard Durrett, Cornell University<br /><br />"An elegantly written book that provides a clear look into the fundamentals." --Yun S. Song, University of California, Berkeley
"Wakeley's book is clearly written and takes time to explain things." --Richard Durrett, Cornell University
"An elegantly written book that provides a clear look into the fundamentals." --Yun S. Song, University of California, Berkeley
"Wakeley's book is clearly written and takes time to explain things." --Richard Durrett, Cornell University
"An elegantly written book that provides a clear look into the fundamentals." --Yun S. Song, University of California, Berkeley
About the Author
John Wakeley is the Thomas D. Cabot Professor of Biology at Harvard University. He has worked extensively in coalescent theory. His research has focused on populations structured by geography and limited migration. Using coalescent models, Dr. Wakeley has addressed questions about the current and historical demography of humans and other species. In May 2004, Dr. Wakeley received a 2002 Presidential Early Career Award for Scientists and Engineers.
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Most Helpful Customer Reviews
6 of 8 people found the following review helpful:
5.0 out of 5 stars
Excellent Introduction,
By Student (Cambridge, MA United States) - See all my reviews
This review is from: Coalescent Theory: An Introduction (Paperback)
This is an excellent introduction to Coalescent Theory. Even though it covers some of the basic mathematics, one with a good foundation in standard population genetics and statistics/mathematics would definitely get more out of this book.
4 of 9 people found the following review helpful:
2.0 out of 5 stars
Not mathematically rigorous,
By Solemn Humor (Virginia, USA) - See all my reviews
This review is from: Coalescent Theory: An Introduction (Paperback)
This book is typical of mathematical biology books that intend to introduce a topic in, say, population genetics and that fail to be rigorous or complete. There are no precise definitions, firm notations, or theorems with proofs. What passes for proof is vague and incomplete. In other words, the book does not put the subject, coalescent theory, on a firm foundation.
There is only one significant application in the first three chapters, a comparison of Neanderthal genetics to human genetics. While this is an interesting application, the presentation is not convincing. There are no exercises, and the book is certainly not suited as a textbook, though it is not appropriate for self-study either because of the mathematical weaknesses mentioned above and because there is no overview of the power of coalescent theory that suggests what rewards the reader will experience by understanding it. The book would have benefitted from having a mathematician as a coauthor.
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