A valuable collection of new and unique techniques for the construction and use of peptide libraries. These powerful methods include protocols for the chemical synthesis of peptide libraries, for constructing peptide libraries that are displayed on the surface of filamentous phage or bacteria, and for the rapid screening of these libraries for molecules with biospecific properties. Additional methods permit identifying specific enzyme substrates, investigating the recognition spectra of various binding proteins, epitope mapping, and identifying mimotopes. State-of-the-art techniques, combined with clear step-by-step instructions, make this book an essential tool in the selection of peptides suitable for drug development.
Combinatorial Peptide Library Protocols
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Shmuel Cabilly presents in Combinatorial Peptide Library Protocols a collection of new and unique techniques for the construction and use of peptide libraries. These powerful methods-often detailed here by their pioneers-include protocols for the chemical synthesis of peptide libraries, for constructing peptide libraries that are displayed on the surface of filamentous phage or bacteria, and for the rapid screening of these libraries for molecules with biospecific properties. Additional methods permit identifying specific enzyme substrates, investigating the recognition spectra of various binding proteins, epitope mapping, and identifying mimotopes. Combinatorial Peptide Library Protocols offers novice and experienced investigators alike the ability to select molecules from a randomized pool having specific biological activities. Its state-of-the-art techniques, combined with clear step-by-step instructions, make this book an essential tool in the selection of peptides suitable for drug development.
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The four general methods to generate and screen a huge combinatorial peptide library (>107 peptides) are: biological libraries such as filamentous phage (1), plasmid (2), or polysome (3) libraries; the "one-bead one-compound" synthetic combinatorial library method or the "Selectide process" (4-6); synthetic peptide library methods that require deconvolution, such as an iterative approach (7,8), positional scanning (9); orthogonal partition approach (10), or recurse deconvolution (11); and synthetic library using affinity column selection method (12,13). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
resin packets, selector protein, tetracycline stock solution, endoprotease specificity, positive beads, synthetic peptide ligands, bead library, substrate motifs, synthetic peptide combinatorial libraries, binding clones, super broth, nonphosphorylated peptides, phage solution, degenerate positions, peptide libraries, extract with phenol, phage isolates, piperidine solution, scanning library, phage pellet, combinatorial library method, scanning libraries, monovalent phage display, synthetic combinatorial libraries, eluted phage Key Phrases - Capitalized Phrases (CAPs): (learn more)
Combinatorial Peptide Library Protocols Edited, Humana Press Inc, Cold Spring Harbor, Boehringer Mannheim, New England Biolabs, Oak Ridge, New York, San Diego, Applied Biosystems, Genetics Institute, Protein Res, George Smith, Auto-Spot Robot, Gene Clean, Detection of Ligand Binding, Peptides International, Protein Eng, Tetrahedron Lett, Trends Biotechnol, University of Missouri, Current Protocols, European Peptide Symposium, Introduction Protein, Leukemia Society of America, Methods Enzymol New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
The four general methods to generate and screen a huge combinatorial peptide library (>107 peptides) are: biological libraries such as filamentous phage (1), plasmid (2), or polysome (3) libraries; the "one-bead one-compound" synthetic combinatorial library method or the "Selectide process" (4-6); synthetic peptide library methods that require deconvolution, such as an iterative approach (7,8), positional scanning (9); orthogonal partition approach (10), or recurse deconvolution (11); and synthetic library using affinity column selection method (12,13). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
resin packets, selector protein, tetracycline stock solution, endoprotease specificity, positive beads, synthetic peptide ligands, bead library, substrate motifs, synthetic peptide combinatorial libraries, binding clones, super broth, nonphosphorylated peptides, phage solution, degenerate positions, peptide libraries, extract with phenol, phage isolates, piperidine solution, scanning library, phage pellet, combinatorial library method, scanning libraries, monovalent phage display, synthetic combinatorial libraries, eluted phage Key Phrases - Capitalized Phrases (CAPs): (learn more)
Combinatorial Peptide Library Protocols Edited, Humana Press Inc, Cold Spring Harbor, Boehringer Mannheim, New England Biolabs, Oak Ridge, New York, San Diego, Applied Biosystems, Genetics Institute, Protein Res, George Smith, Auto-Spot Robot, Gene Clean, Detection of Ligand Binding, Peptides International, Protein Eng, Tetrahedron Lett, Trends Biotechnol, University of Missouri, Current Protocols, European Peptide Symposium, Introduction Protein, Leukemia Society of America, Methods Enzymol New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 34
books:
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34
books
cite this book:
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- Modern Methods in Carbohydrate Synthesis (Labour Economics Section) by Shaheer H. Khan on page 73, and page 82
- Monoclonal Antibody Protocols (Methods in Molecular Biology, Vol 45) by William C. Davis in Front Matter
- Ribozyme Protocols (Methods in Molecular Biology) by Philip C. Turner in Front Matter
- Genetic Engineering (Global Issues) by Jenny Bryan in Front Matter
- Antibodies by Edward Harlow on page 280
See all 34 books this book cites
- Protein Targeting Protocols (Methods in Molecular Biology) by Roger A. Clegg in Front Matter
- Bioinformatics: Methods and Protocols (Methods in Molecular Biology) by Stephen Misener in Front Matter
- Free Radical and Antioxidant Protocols (Methods in Molecular Biology) by Donald Armstrong in Front Matter
- Protein Lipidation Protocols (Methods in Molecular Biology) by Michael H. Gelb in Front Matter
- Forensic DNA Profiling Protocols (Methods in Molecular Biology) by Patrick J. Lincoln in Front Matter
See all 34 books citing this book
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