"This book is helpful in understanding and designingpharmacokinetic studies, illustrating basic concepts and noting thespecies differences. . . The book does a good job of explaining aconcept and then expands with more specific examples. It provides agood base for pharmacokinetic modeling and illustrates the pitfallswith interspecies extrapolation." (Doody's, 21 October 2011)
From the Back Cover
Now in a revised edition, Comparative Pharmacokinetics:Principles, Techniques, and Applications
presents theprinciples and techniques of comparative and veterinarypharmacokinetics in a detailed yet practical manner. Designed as atool for ensuring that pharmacokinetics studies are properlydesigned and correctly interpreted, the book provides completecoverage of the conceptual basis of pharmacokinetics as used forquantifying biological processes from the perspectives ofphysiology and medicine. New chapters have been added onquantitative structure permeability relationships andbioequivalence, and a number of existing chapters have beensignificantly revised and expanded to provide a current resourcefor veterinary and comparative pharmacokinetics.
The second edition retains the structure of the first, beginningwith the basic principles of physiology and then moving into theprimary approaches used in pharmacokinetic modeling, includingextensive coverage of dosage regimens and adjustments, interspeciesextrapolation, experimental design, data collection and analysis,and residues and withdrawal times. With broad human and animalspecies coverage, Comparative Pharmacokinetics is essentialreading for those working in drug research and development, as wellas those with advanced interest in pharmacology and toxicology inveterinary or comparative medicine.
Provides a detailed but understandable reference on theconceptual basis of veterinary and comparativepharmacokinetics
Covers practical applications to both animal and humanmedicine
Offers essential information for ensuring thatpharmacokinetics studies are correctly designed andinterpreted
Includes new chapters on quantitative structure permeabilityrelationships and bioequivalence, as well as fully revised andexpanded chapters throughout
Presents a fully rewritten chapter on simultaneouspharmacokinetic-pharmacodynamic modeling to reflect its newlywidespread role in comparative medicine
Facilitates the reader in making conceptual linkages betweentheory and applications with expanded cross-referencing betweentopics