It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.
FREE Two-Day Shipping for students on millions of items. Learn more |
Book Description
Product Details
Would you like to update product info or give feedback on images?
|
More About the Author
Discover books, learn about writers, read author blogs, and more.
Customer Reviews
|
There are no customer reviews yet.
|
|||
|
Video reviews
|
Inside This Book
(learn more)
First Sentence:
A former colleague of the author used to maintain that to make a development decision for a new antibacterial, it was necessary to know two things about the compound: its MIC and the achievable blood level. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
cytokinetic modeling, preclinical workup, physiological pharmacokinetic modeling, quiescent fraction, cell loss factor, drug development decisions, preclinical drug development, cytokinetic parameters, cytokinetic models, drug metabolism and toxicity, log kill, cellular pharmacokinetics, antigenic diversity threshold, rational drug development, collateral sensitivity, pharmacodynamic modeling, interspecies scaling, cell cycle time, metastatic cells, tumor cell populations, drug developers, classical inhibitors, cumulative toxicity Key Phrases - Capitalized Phrases (CAPs): (learn more)
Antibacterial Model, Hours Figure, Time Bact, Time Tumor, Time Kidney Bone, Time Lung Spleen Heart Remainder, Physiological Pharmacokinetic Model Modeling Adriamycin, Clinical Modeling Study, Days Figure New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
A former colleague of the author used to maintain that to make a development decision for a new antibacterial, it was necessary to know two things about the compound: its MIC and the achievable blood level. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
cytokinetic modeling, preclinical workup, physiological pharmacokinetic modeling, quiescent fraction, cell loss factor, drug development decisions, preclinical drug development, cytokinetic parameters, cytokinetic models, drug metabolism and toxicity, log kill, cellular pharmacokinetics, antigenic diversity threshold, rational drug development, collateral sensitivity, pharmacodynamic modeling, interspecies scaling, cell cycle time, metastatic cells, tumor cell populations, drug developers, classical inhibitors, cumulative toxicity Key Phrases - Capitalized Phrases (CAPs): (learn more)
Antibacterial Model, Hours Figure, Time Bact, Time Tumor, Time Kidney Bone, Time Lung Spleen Heart Remainder, Physiological Pharmacokinetic Model Modeling Adriamycin, Clinical Modeling Study, Days Figure New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 16
books:
See all 16 books this book cites
1
book
cites this book:
- Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development by A. Yacobi in Back Matter (1), Back Matter (2), and Back Matter (3)
- New Trends in Pharmacokinetics (Nato Science Series: A:) by Aldo Rescigno in Back Matter (1), Back Matter (2), and Back Matter (3)
- Cancer Modeling (Statistics: A Series of Textbooks and Monographs) by J.R. Thompson in Back Matter (1), and Back Matter (2)
- Pharmacokinetics and Cancer Chemotherapy (Genome Analysis,) by P. Workman in Back Matter (1), and Back Matter (2)
- Preclinical and Clinical Modulation of Anticancer Drugs (Handbooks in Pharmacology and Toxicology) by Kenneth D. Tew in Back Matter
See all 16 books this book cites
- Interspecies Pharmacokinetic Scaling: Principles And Application of Allometric Scaling by Iftekhar Mahmood on page 36
Books on Related Topics
(learn more)
|
Tag this product(What's this?)Think of a tag as a keyword or label you consider is strongly related to this product.
Tags will help all customers organize and find favorite items. |
Sell a Digital Version of This Book in the Kindle Store
If you are a publisher or author and hold the digital rights to a book, you can sell a digital version of it in our Kindle Store.
Learn more
Customer Discussions
|
This product's forum
Active discussions in related forums
Search Customer Discussions
|
Related forums
|
Listmania!
So You'd Like to...
Look for Similar Items by Category
- Books > Computers & Technology > Computer Science > Modeling & Simulation
- Books > Computers & Technology > Graphic Design > 3D Graphics
- Books > Medical Books > Pharmacology > Pharmacy
- Books > Medical Books > Pharmacology > Product Development
- Books > New & Used Textbooks > Computer Science
- Books > New & Used Textbooks > Medicine & Health Sciences > Allied Health Services > Pharmacy
- Books > New & Used Textbooks > Medicine & Health Sciences > Medicine > Basic Sciences > Pharmacology
- Books > New & Used Textbooks > Science & Mathematics
- Books > Science & Math > Biological Sciences > Bioinformatics
