Concepts in Toxicology [Hardcover]

John H. Duffus (Author), Douglas M. Templeton (Author), Monica Nordberg (Author), IUPAC / International Union of Pure and Applied Chemistry (Contributor)

Book Description

Publication Date: October 23, 2009 | ISBN-10: 0854041575 | ISBN-13: 978-0854041572 | Edition: 1

This book provides full explanations of the meaning of toxicological terms chosen for their importance and complexity from the point of merging chemistry and toxicology. Linguistic barriers can often lead to problems in obtaining a common understanding of terminology at international level and between disciplines. The explanatory definitions, provided in the book, should help to break down such barriers. It should also facilitate the use of chemistry in relation to risk assessment.

Editorial Reviews

Review

A Vocabulary of Toxicology P>Concepts in Toxicology P>John Duffus, Douglas Templeton and Monica Nordberg RSC Publishing 2009, Cambridge, UK, 179pp, (HB), ISBN 9780854041572 P>Reviewed by T M T Sheehan P>Next time my teenage sons moan that a decision is 'a bit random' I shall counter, that on the contrary, it was entirely non-stochastic. What am I on about? Well, each population has its own vocabulary and toxicologists are no exception. In the context of that discipline we could all probably distinguish between 'acute' and 'chronic' and between 'risk' and 'hazard', but what about 'effect' and 'response' or 'bioaccessibility' and 'bioavailability'? These concepts, and a whole host more, are addressed in this slim volume, the objective of which, the authors state, 'is to give full explanations of the meaning and usage of key toxicological terms.' The requirement for this, the authors argue, arises out of the need to comply with the increasing amount and complexity of chemicals legislation (eg Reach) and the fact that many of the classical tenets of toxicology (eg LD50) have been largely superceded as understanding of the mechanisms of toxicity has developed. P>The book comprises four chapters or 'Concept Groups': Fundamental principles of toxicology; Molecular and cellular toxicology; Whole organism toxicology; Environmental toxicology. Each concept discussion is prefaced with an Iupac-approved definition. Topics covered range from the classical pharmacokinetic parameters to more recent concepts such as elemental speciation as exemplified by the relative toxicities of Cr(iii) and Cr(vi). In addition, there is discussion of such issues as endocrine disruption, multiple chemical sensitivity and nanoparticle toxicity. P>I found this an informative and readable little book. It would be a good primer for those new to regulatory toxicology and provides a valuable update for toxicologists of all persuasions. It will also be of interest to those who require a concise introduction to the subject, although for the complete novice the earlier Fundamental toxicology (J H Duffus and H G J Worth eds; RSC Publishing, 2006) would be more appropriate. Chemistry World, 2010, 7(5), p. 61

Book Description

This book provides full explanations of the meaning of toxicological terms chosen for their importance and complexity from the point of merging chemistry and toxicology. Linguistic barriers can often lead to problems in obtaining a common understanding of terminology at international level and between disciplines. The explanatory definitions, provided in the book, should help to break down such barriers and will be helpful to chemists, pharmacologists, toxicologists, risk assessors, regulators, medical practitioners, regulatory authorities, and everyone with an interest in the relationship of chemistry to toxicology. It should also facilitate the use of chemistry in relation to risk assessment.

See all Editorial Reviews

Product Details

• Hardcover: 179 pages
• Publisher: Royal Society of Chemistry; 1 edition (October 23, 2009)
• Language: English
• ISBN-10: 0854041575
• ISBN-13: 978-0854041572
• Product Dimensions: 9.1 x 6.1 x 0.7 inches
• Shipping Weight: 15.5 ounces (View shipping rates and policies)
• Amazon Best Sellers Rank: #2,754,435 in Books (See Top 100 in Books)

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