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Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms (History)
 
 
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Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms (History) [Hardcover]

Errol C. Friedberg (Author)

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Book Description

March 1, 1997 0879695072 978-0879695071 1
A brief history of the discovery of the more important mechanisms by which cells respond to DNA damage. The study, which introduces the study of DNA mutagenesis and repair, is aimed at advanced undergraduates or graduate students, as well as researchers in a variety of fields.

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More About the Author

Errol Friedberg was born in South Africa in 1937 and immigrated to the US in 1963. He is a trained pathologist and molecular biologist who works in the field of DNA damage and repair. He published the first textbook on this topic ("DNA Repair") in 1984 and has since contributed two editions of a more comprehensive text ("DNA Repair & Mutagenesis") with multiple co-authors. Friedberg has a passionate interest in the history of molecular biology and related topics. He has published a history of the DNA repair field ("Correcting the Blueprint of Life-An Historical Account of the Discovery of DNA Repair Mechanisms") as well as a book on the writings of James Watson, the famous co-discoverer of the structure of DNA and the author of "The Double Helix", entitled "The Writing Life of James D. Watson". Friedberg is a professor at the University of Texas Southwestern Medical Center at Dallas and has documented a history of this institution ("From Rags to Riches: The Phenomenal Rise of the University of Texas Southwestern Medical Center at Dallas"). Most recently he has completed an authorized biography of another famous pioneer of molecular biology, Sydney Brenner ("Sydney Brenner: A Biography"). In 1992 Friedberg published a small book on cancer for lay readers ("Cancer Answers-Encouraging Answers to 25 Questions You Were Always Afraid to Ask").



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Inside This Book (learn more)
First Sentence:
IN HIS HISTORICAL ACCOUNTING of the emergence and efflorescence of molecular biology in the mid 20th century entitled The Eighth Day of Creation: Makers of the Revolution in Biology, Horace Judson reminds us that "mutations obtained one way or another have . . . always been the chief tool of experimental genetics." Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
excision repair mode, reactivation phenomena, liquid holding recovery, genomic injury, irradiated phage, multiplicity reactivation, strand discrimination, host cell reactivation, photoreactivating light, photoreactivating enzyme, dimer content, irradiated bacteria, enzymatic photoreactivation, alkylation damage, prophage induction, recovery phenomena, thymine dimers, mispaired bases, ultraviolet mutagenesis, pyrimidine dimers, repair field, apurinic sites, adapted cells, repair modes, mismatch correction
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cold Spring Harbor, Dick Setlow, Oak Ridge, United States, Evelyn Witkin, New York, Stan Rupert, Jane Setlow, Jim Watson, Paul Howard-Flanders, Walter Harm, Matt Meselson, Phil Hanawalt, Ruth Hill, Salvador Luria, University of Chicago, Johns Hopkins, Alex Hollaender, Renato Dulbecco, Albert Kelner, Bob Haynes, Dick Boyce, Horace Judson, John Cairns, Miroslav Radman
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