This book is a unique compendium of the latest information on cytokine knockouts. Each chapter-written by the leading scientists who created or studied each knockout-illuminates the physiological consequences of deficiency in a particular cytokine and relates the phenotype to other knockout mice and to human diseases. The effects discussed range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Most of the key knockouts of cytokines or receptors, including IL-1 through 8, IFNs, TGFs, TNF, LT, CD40, LIF, CSFs, c-mpl, gp130, and ICE, are thoroughly reviewed.
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Editorial Reviews
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...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. -from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne
". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal
". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal
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Inside This Book
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First Sentence:
The three chains of the interleukin-2 receptor (IL-2R) are differentially expressed on developing lymphocytes: the common yc is already found on early developmental stages, where it forms part of the IL-7 receptor through which stromal-cell derived IL-7 promotes the expansion of B-cell precursors (13) and early thymocytes (14). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
human alveolar proteinosis, compact layer cells, marrow granulopoiesis, blood neutrophil numbers, null pups, hypoplastic development, labyrinthine zone, null animals, thymic cellularity, turpentine injection, cytokine knockouts, severe congenital neutropenia, lymphoid development, gene knockout studies, immunological homeostasis, osteoclast development, mutant mice, monocytogenes infection, primary spongiosa, pulmonary alveolar proteinosis, fever response, heterozygous littermates, wildtype mice, sterile inflammation, chronic neutropenia Key Phrases - Capitalized Phrases (CAPs): (learn more)
Contemporary Immunology, Cytokine Knockouts Edited, Muegge Humana Press Inc, New York, Genes Dev, Cell Biol, Cancer Res, Mechanism of Action, Van Snick, Brain Res, Growth Factor Res, Stimulation of B-cell, Cytokine Receptor Gene Deletions, Effects of Cytokine Production, Endocrine Rev, Genes Der, Mice Mice, Nature Genet, Plus D-gal, Serono-Baker Diagnostics System, Summary of the Effects of Cytokine, Van Zee New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
The three chains of the interleukin-2 receptor (IL-2R) are differentially expressed on developing lymphocytes: the common yc is already found on early developmental stages, where it forms part of the IL-7 receptor through which stromal-cell derived IL-7 promotes the expansion of B-cell precursors (13) and early thymocytes (14). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
human alveolar proteinosis, compact layer cells, marrow granulopoiesis, blood neutrophil numbers, null pups, hypoplastic development, labyrinthine zone, null animals, thymic cellularity, turpentine injection, cytokine knockouts, severe congenital neutropenia, lymphoid development, gene knockout studies, immunological homeostasis, osteoclast development, mutant mice, monocytogenes infection, primary spongiosa, pulmonary alveolar proteinosis, fever response, heterozygous littermates, wildtype mice, sterile inflammation, chronic neutropenia Key Phrases - Capitalized Phrases (CAPs): (learn more)
Contemporary Immunology, Cytokine Knockouts Edited, Muegge Humana Press Inc, New York, Genes Dev, Cell Biol, Cancer Res, Mechanism of Action, Van Snick, Brain Res, Growth Factor Res, Stimulation of B-cell, Cytokine Receptor Gene Deletions, Effects of Cytokine Production, Endocrine Rev, Genes Der, Mice Mice, Nature Genet, Plus D-gal, Serono-Baker Diagnostics System, Summary of the Effects of Cytokine, Van Zee New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 15
books:
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6
books
cite this book:
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- Cytokine Knockouts (Contemporary Immunology) by Giamila Fantuzzi on 25 pages
- Tumor Necrosis Factors: Structure, Function, and Mechanism of Action (Immunology Series) by Bharat B. Aggarwal on page 126
- The Nature of Immunologic Tolerance (Medical Intelligence Unit) by David W. Scott on page 400
- Fields Virology by David M. Knipe on page 221
- Fundamental Immunology by William E. Paul on page 401
See all 15 books this book cites
- Cytokine Knockouts (Contemporary Immunology) by Giamila Fantuzzi on 28 pages
- Therapeutic Interventions in the Complement System (Contemporary Immunology) by John D. Lambris in Front Matter
- Chemokines in Disease: Biology and Clinical Research (Contemporary Immunology) by Caroline A. Hébert in Front Matter
- Autoimmune Reactions (Contemporary Immunology) by Sudhir Paul in Front Matter
- The Jak-Stat Pathway in Hematopoiesis and Disease (Molecular Biology Intelligence Unit) by Alister C. Ward on page 43
See all 6 books citing this book
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