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Cytokines and Pain (Progress in Inflammation Research) [Hardcover]

L.R. Watkins (Author), S.F. Maier (Author)

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Book Description

ISBN-10: 3764358491 | ISBN-13: 978-3764358495 | Publication Date: December 7, 1998 | Edition: 1

Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

#outer_postBodyPS { display: none; } #psGradient { display: none; } #psPlaceHolder { display: none; } #psExpand { display: none; } Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

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Product Details

Hardcover: 244 pages
Publisher: Birkh�user Basel; 1 edition (December 7, 1998)
Language: English
ISBN-10: 3764358491
ISBN-13: 978-3764358495
Product Dimensions: 9.2 x 6.4 x 0.8 inches
Shipping Weight: 1.5 pounds (View shipping rates and policies)
Amazon Best Sellers Rank: #4,953,252 in Books (See Top 100 in Books)

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Inside This Book (learn more)

First Sentence:
Cytokines are small, non-structural proteins with molecular weights ranging from 8-40,000 Daltons. Read the first page

Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
nerve cryoneurolysis, hyperalgesic responses, sensory hyperexcitability, neurons having axons, sciatic cryoneurolysis, hyperalgesic mediators, inflammatory hyperalgesia, sensory excitability, thermal hypersensitivity, formalin hyperalgesia, adjuvant inflammation, nociceptive sensory neurons, nociceptive behaviors, neuropathic pain states, hyperalgesic agents, mechanical hyperalgesia, thermal hyperalgesia, evoked hyperalgesia, spinal cord glia, mechanical hypersensitivity, hyperalgesic effects, chronic constriction injury, following nerve injury, hyperalgesic state, mechanical allodynia

Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, Proc Natl Acad Sci, Biol Chem, Exp Med, Neurosci Lett, Clin Invest, Exp Neurol, Verlag Basel, New York, Agents Actions, Comp Neurol, Raven Press, Biochem Biophys Res Commun, Life Sci, Dev Comp Immunol, Faculty of Medicine, Infect Dis, Neurosci Res, Proc Soc Neurosci, Ann Neurol, Eur Cytokine Netw, Group Ipsilateral Contralateral Ipsilateral Contralateral, Immunol Today, Lymphokine Cytokine Res

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Citations (learn more)

This book cites 6 books:

HIV: Molecular Biology and Pathogenesis: Viral Mechanisms, Volume 48 (Advances in Pharmacology) by J. Thomas August on page 80, and page 82
Inducible Enzymes in the Inflammatory Response (Progress in Inflammation Research) by Willoughby in Back Matter
Medicinal Fatty Acids in Inflammation (Progress in Inflammation Research) by J. Kremer in Back Matter
Methods in Pulmonary Research by Stefan Uhlig in Back Matter
Cytokines in Severe Sepsis & Septic Shock (Progress in Inflammation Research) by H. Redl in Back Matter

See all 6 books this book cites

29 books cite this book:

Pain and Neuroimmune Interactions by Nayef E. Saad� on page 52, page 53, and page 187
Cytokines and Joint Injury (Progress in Inflammation Research) by Wim B. van den Berg in Back Matter
High Throughput Screening for Novel Anti-Inflammatories (Progress in Inflammation Research) by Michael Kahn in Front Matter
Antibiotics as Anti-Inflammatory and Immunomodulatory Agents (Progress in Inflammation Research) by Bruce K. Rubin in Back Matter
The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer (Progress in Inflammation Research) by Zofia Zukowska in Back Matter

See all 29 books citing this book

Books on Related Topics (learn more)

Neuropsychiatry by Randolph B. Schiffer

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