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DNA Methylation: Approaches and Applications
 
 
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DNA Methylation: Approaches and Applications [Hardcover]

Manel Esteller (Editor)

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Book Description

084932050X 978-0849320507 July 26, 2004 1
DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book provides a balance between articles clarifying methodological details and more general review chapters that offer broad biological perspectives on DNA methylation. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing.

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Inside This Book (learn more)
First Sentence:
We can lump within the scope of the enigmatic word of "epigenetics" all the heritable changes in gene expression patterns that are based on factors other than straightforward DNA sequences. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
decitabine treatment, gene promoter hypermethylation, restriction landmark genomic scanning, immunolocalization analysis, demethylating agents, demethylating activity, gene reactivation, aberrant promoter methylation, methylation markers, island hypermethylation, genomic hypomethylation, silenced genes, methylated genes, methylation machinery, histone deacetylase inhibition, mixing gels, methylation alterations, aberrant methylation, chip assays, island methylation, bladder cancer cells, methylation levels, methylation targets, methylation events, epigenetic inactivation
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Nucleic Acids Res, Cancer Inst, Cell Biol, Genes Dev, Cancer Treat, Trends Genet, Cancer Chemother, Cell Genet, Cell Res, Genome Res, Nature Genet, Oncomethylome Sciences, Survival Indication Drug, Bone Marrow Transplant, Cancer Lett, Lancet Oncol, Methods Mol, Total Dose Schedule Responses Duration
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