DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling [Hardcover]

Pierre Baldi (Author), G. Wesley Hatfield (Author)

Book Description

Publication Date: September 30, 2002 | ISBN-10: 0521800226 | ISBN-13: 978-0521800228 | Edition: 1

Massive data acquisition technologies--such as genome sequencing, high-throughput drug screening, and DNA arrays--are in the process of revolutionizing biology and medicine. This concise, user-friendly and interdisciplinary guide to DNA microarray technology is an introduction and a reference for both biologists and computational scientists. The authors describe the underlying technologies and offer an awareness of the "noise" and pitfalls present in the data generated. They also provide an idea of the different data mining techniques and algorithms that are available to interpret data, and the advantages and disadvantages of each in differing situations.

Editorial Reviews

Review

Review of the hardback: 'The book, written by Baldi and Hatfield, is an important and timely addition to the DNA microarray literature ... the first several chapters of the book provide an easy-to-digest overview of the current state of DNA microarrays.' Briefings in Functional Genomics & Proteomics

Review of the hardback: 'Writing a book such as this was a challenging remit and one that the authors have achieved with great success.' Human Genomics

Review of the hardback: 'I recommend very highly this book to statisticians in particular.' Journal of Statistical Computation & Simulation

Book Description

DNA microarrays are in the process of revolutionizing biology and medicine. They can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study development and evolution, to determine the function of new genes, to infer the role genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. This inter-disciplinary introduction to DNA arrays will be essential reading for all researchers wanting to take advantage of this powerful new technology.

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Product Details

• Hardcover: 230 pages
• Publisher: Cambridge University Press; 1 edition (September 30, 2002)
• Language: English
• ISBN-10: 0521800226
• ISBN-13: 978-0521800228
• Product Dimensions: 9.9 x 5.9 x 0.6 inches
• Shipping Weight: 1 pounds (View shipping rates and policies)
• Average Customer Review: 3.7 out of 5 stars  See all reviews (3 customer reviews)
• Amazon Best Sellers Rank: #1,840,074 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews

7 of 7 people found the following review helpful:

1.0 out of 5 stars A stringing together of short essays., June 6, 2005

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Zac (USA) - See all my reviews

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This review is from: DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling (Hardcover)

This book tries to combine a practical and theoretical point of view concering microarray expermiments and the data analyis thereof. This is a very honourable goal. Unfortunatelly, it fails. An indicator for this can already be seen in the low number of pages. This book has less than 140 pages (I exclude the last chapter and the appendix). It is clear, that it is impossible to discuss in detail this topic in this limited number of pages. Hence, during reading the chapters one gets the feeling, that one reads short essays which are stringed together. At no point the authors go into detail but give only a short idea and references.

I see no reason, why I should recommend this book to anyone. It is in its current form just immature. My prediction: There will be no second edition because even its basic substance is very weak.

Some words to the last chapter (systems biology). This is indeed the most interesting and best chapter of the book (35 pages) without going into details as the rest of the book. I think according to this chapter one realize under which premise this book was written. Unfortunatelly, combining buzz worlds in short essays is not enough for a good book. Sorry guys, I think you can do better!

9 of 16 people found the following review helpful:

5.0 out of 5 stars By far the best book on DNA microarrays., October 14, 2002

By A Customer

This review is from: DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling (Hardcover)

"Very complete : covers both the experimental and the computational methods with specific examples. Written by two top scientists who have worked hard at complementing each other's strengths. I particularly enjoyed the last chapter on Systems Biology which provides a masterful overview of current resaerch trends."

8 of 16 people found the following review helpful:

5.0 out of 5 stars Excellent book. Recommended., November 12, 2002

By A Customer

This review is from: DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling (Hardcover)

This book has a good balance between experimental and computational methods. It provides a description of DNA microarray technologies, experimental protocols, and the multiple sources of noise and variability. The book contains an insightful overview of the computational issues and available algorithms for data analysis from differential expression, to dimensionality reduction and visualization (e.g. PCA), to clustering (e.g. hierarchical). New methods are described to gether with a good overview of available software, data bases, web sites, and other resources, as well as several "walk through" examples. I particularly enjoyed the last chapter on Systems Biology.