DNA microarray, or DNA chip, technology is a new and powerful means of discovering, characterizing, and analyzing genes and their expression patterns. The potential of this technology is huge and its applications are widespread across the many fields of biological and biomedical research. This manual assembles and synthesizes the expertise of over 30 innovators in this emerging field to provide authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for extensive image and data analysis. Designed to extend and to complement the information in the best-selling laboratory manual Molecular Cloning, and presented in the same clear, user-friendly format, this book is an essential resource for investigators studying the molecular profiles of gene expression in any experimental system.
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Editorial Reviews
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DNA Microarrays: A Molecular Cloning Manual provides the reader with a wealth of information about how to manufacture microarrays, design and carry out microarray experiments, and analyze microarray data. The editors have lined up an impressive cast of authors who are in many cases the world experts on the particular aspect of microarrays technology that they describe... Overall, this is an excellent book, which will prove invaluable to any researcher involved in microarray analysis. It offers a comprehensive overview of the microarray technology as well as its satellite techniques, such as LCM, CGH arrays, and tissue arrays, and is the most comprehensive and up-to-date manual currently available on DNA microarrays. Journal of Proteome Research DNA Microarrays is a welcome addition to the library of anyone using microarrays. In the tradition of Cold Spring Harbor manuals, this volume provides detailed protocols for every aspect of the technology, from microarray fabrication to data analysis. The protocols cull the expertise of top microarray researchers and cover both expression profiling and analysis of genomic DNA... Overall, the protocols are comprehensive and sufficiently detailed for newcomers to microarrays, and the book contains enough pearls to ensure that it will also be welcomed in experienced microarrays labs. Nature Cell Biology
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10 of 10 people found the following review helpful:
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By Janos Demeter (Mountain View, CA USA) - See all my reviews
This review is from: DNA Microarrays: A Molecular Cloning Manual (Paperback)
This book is very much like its well known predecessor, the currently 3 volume Molecular Cloning Manual with which it shares an editor and a similar title (in fact, it could pass as volume 4). Overall it gives a good coverage of spotted microarray technology starting from the preparation of probes and slides to sample preparation and hybridization. In addition to expression profiling areas covered include uses of microarrays for analysis of chromatin immunoprecipitation samples, DNA copy number determination, and detection of genetic polymorphisms (oligo arrays). Tissue-arrays and micro-dissection techniques for sample preparation are also described. The bioinformatics section is less extensive than the experimental parts, but the chapters on clustering, self organizing maps and databases serve as good introductions to these areas. I especially liked the image acquisition, normalization and quality control sections. These reviews presented their material in a very clear and sensible way. Each chapter starts with a short summary of the relevant background. These introductions are very concise, straightforward, jargon-free and up to date in their references. They are written by leading experts of their fields. In addition, there are several "Information Panels" with similar qualities, covering somewhat more general background material. This is a very nice looking book; it is a pleasure to look at and to hold. I am sure every lab that uses microarrays could benefit from it.
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Key Phrases - Statistically Improbable Phrases (SIPs):
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please see protocol, pine tree method, postprinting processing, compatible pools, common reference set, cell line adherent, thiocyanate homogenization buffer, generate high backgrounds, genome oligo, replicator tool, quill pins, wear appropriate gloves, oligo sets, extension fluorescence, sucrose gradient buffer, microdissected cells, tag oligonucleotides, fluorescent contaminants, replicate slides, spot morphology, donor block, fluidics station, printing buffer, manual microdissection, suit other types Key Phrases - Capitalized Phrases (CAPs): (learn more)
Special Equipment, Nucleic Acids Res, New York, Chromosome Genetic, Web Site, Amersham Biosciences, Applied Biosystems, Cancer Institute, Tree View, Cold Spring Harbor, Additional Materials, Perkin Elmer, Phase Lock Gel, Molecular Probes, National Institutes of Health, Genome Res, University of California, Research Genetics, Stanford University, Superfrost Plus, East Melbourne, Methods Enzymol, Fisher Scientific, New England Biolabs, Alleles Allele New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
please see protocol, pine tree method, postprinting processing, compatible pools, common reference set, cell line adherent, thiocyanate homogenization buffer, generate high backgrounds, genome oligo, replicator tool, quill pins, wear appropriate gloves, oligo sets, extension fluorescence, sucrose gradient buffer, microdissected cells, tag oligonucleotides, fluorescent contaminants, replicate slides, spot morphology, donor block, fluidics station, printing buffer, manual microdissection, suit other types Key Phrases - Capitalized Phrases (CAPs): (learn more)
Special Equipment, Nucleic Acids Res, New York, Chromosome Genetic, Web Site, Amersham Biosciences, Applied Biosystems, Cancer Institute, Tree View, Cold Spring Harbor, Additional Materials, Perkin Elmer, Phase Lock Gel, Molecular Probes, National Institutes of Health, Genome Res, University of California, Research Genetics, Stanford University, Superfrost Plus, East Melbourne, Methods Enzymol, Fisher Scientific, New England Biolabs, Alleles Allele New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 2
books:
- In Situ Hybridization: A Practical Approach (Practical Approach Series) by D. G. Wilkinson on page 617
- Companion Web Site by Larry E. Long in Table of Contents
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