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DNA Repair and Mutagenesis [Paperback]

Errol Freidberg (Author), Errol C. Friedberg (Author), Friedberg (Author)
4.8 out of 5 stars  See all reviews (4 customer reviews)


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Book Description

January 1995 1555810888 978-1555810887 Revised
This is a major revision and updating of the classic work in the field of DNA repair by Errol Friedberg published in 1985. The authors have extensively revised the original text and provided more than 4000 references to current primary research literature. In addition, there are four new chapters on mutagenesis. The book will serve as an important reference resource for all courses in DNA repair and mutagenesis, and for molecular biologists working in many areas of cancer research

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Product Details

  • Paperback: 698 pages
  • Publisher: American Society Microbiology; Revised edition (January 1995)
  • Language: English
  • ISBN-10: 1555810888
  • ISBN-13: 978-1555810887
  • Product Dimensions: 11 x 8.3 x 1.4 inches
  • Shipping Weight: 3.8 pounds
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (4 customer reviews)
  • Amazon Best Sellers Rank: #1,826,665 in Books (See Top 100 in Books)

More About the Author

Errol Friedberg was born in South Africa in 1937 and immigrated to the US in 1963. He is a trained pathologist and molecular biologist who works in the field of DNA damage and repair. He published the first textbook on this topic ("DNA Repair") in 1984 and has since contributed two editions of a more comprehensive text ("DNA Repair & Mutagenesis") with multiple co-authors. Friedberg has a passionate interest in the history of molecular biology and related topics. He has published a history of the DNA repair field ("Correcting the Blueprint of Life-An Historical Account of the Discovery of DNA Repair Mechanisms") as well as a book on the writings of James Watson, the famous co-discoverer of the structure of DNA and the author of "The Double Helix", entitled "The Writing Life of James D. Watson". Friedberg is a professor at the University of Texas Southwestern Medical Center at Dallas and has documented a history of this institution ("From Rags to Riches: The Phenomenal Rise of the University of Texas Southwestern Medical Center at Dallas"). Most recently he has completed an authorized biography of another famous pioneer of molecular biology, Sydney Brenner ("Sydney Brenner: A Biography"). In 1992 Friedberg published a small book on cancer for lay readers ("Cancer Answers-Encouraging Answers to 25 Questions You Were Always Afraid to Ask").



 

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4.8 out of 5 stars (4 customer reviews)
 
 
 
 
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1 of 1 people found the following review helpful:
4.0 out of 5 stars Simplify, Simplify, Simplify, March 16, 2010
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Ron Braithwaite "Hummingbird God" (El Indio, Texas United States) - See all my reviews
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This tome, while a reasonably complete expose of current science regarding DNA repair, is, perhaps, less than a comprehensive, easily understood discussion of the subject. It is OK as a reference source but certainly not for light bedtime reading.

I'll explain. I believe that part of a good teacher's excellence is his ability to make a complex subject comprehensible to his students. Certainly, a reader can criticize my criticism in claiming that this subject is sooooo complex as to defy simplification. I completely disagree and aim to prove it. I believe that a tome of this sort can be reduced to two forms of information and data: 1. to put theory and data into a comprehensive form. 2. to place complex data into a more detailed form.

I think the authors attempted this by placing a summary at the end of each chapter. This is commendable and routine but, in my opinion, inadequate. It is science for the initiated but, as a reasonably well-read pathologist, I really think I should be able to follow the discussion without excessive difficulty. Naively, perhaps, I regard this as more the authors' problem than my problem.

Braithwaite
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6 of 9 people found the following review helpful:
5.0 out of 5 stars The Definitive Book, January 18, 2006
The first edition of this book was published in 1995 and it was noted then that this was a field that was rapidly progressing. Progress has not slowed, and for the past several years the authors, now expanded to five, have been reviewing, re-writing where necessary, and expanding the book to nearly double it's original size with nearly double the number of illustrations.

As a textbook, this volume is suitable for the advanced undergraduate and graduate students. As a reference book, this volume is the most complete survey of the field to date. It is excellent in its historical approach that illustrates how the present state of knowledge was reached. This provides a background understanding that sometimes opens the door to other types of research that might be conducted. There is further a series of comments on the directions that current research is going. Each chapter is heavily referenced, with 10,000 references to back up the content of the book.

This is the definite book on the subject.
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10 of 16 people found the following review helpful:
5.0 out of 5 stars The best!, March 9, 2000
This review is from: DNA Repair and Mutagenesis (Paperback)
The most complete book in the subjet Cover all aspects of DNA repair Rich in experimental details If you're interessted in DNA repair this book is the bible
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Inside This Book (learn more)
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First Sentence:
When DNA was ultimately acknowledged more than a half century ago to be the molecule that encodes genetic information, it was intuitively recognized by James Watson and Francis Crick that occasional mistakes might arise during its replication and that this might contribute to mutations that appear in new generations of cells. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
damage tolerance and mutagenesis, adapted front reference, detective repair, defective repair synthesis, pyrintidine dieters, xeroderma pigmentosunt, defective biological responses, spontaneous base damage, alternative excision repair, ntisntatch repair, xerodernta pigmentosum, ntanunalian cells, chicken foot structure, homologous reconthination, excision repair mode, opposite photoproducts, ada protein, coming nucleotide, strand discrimination signal, daughter strand gap repair, fork regression, bimodal incision, preincision complex, repair gene polymorphisms, mutagenic processing
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Nucleic Acids Res, New York, Cancer Res, Cell Biol, Genes Dev, Genes Der, Color Plate, Van Houten, Cold Spring Harbor, Marcel Dekker, Prot Natl, Academic Press, Humana Press, Proc Natl, Cell Biel, Plenum Publishing Corp, Genes Dec, The Netherlands, United Kingdom, Cell Res, Trends Genet, Genes Dee, United States, Mice Defective, Cell Sci
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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