With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.
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Inside This Book
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First Sentence:
The ability to efficiently disrupt gene expression has become an important experimental approach for studying the biological function of a gene at the single-cell level and in intact organisms. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
hairpin loop domain, transgenic mouse cells, unmodified ribozyme, circular oligonucleotides, circular oligodeoxynucleotide, antisense oligoribonucleotides, oligonucleotides encapsulated, ribozyme expression, hybridizing arms, propyne pyrimidines, phosphodiester oligonucleotides, uptake enhancers, chimeric ribozymes, oligonucleotide derivatives, cytoplasmic delivery, oligodeoxynucleotide phosphorothioates, serum nucleases, phosphorothioate linkages, oligonucleotide transport, oligonucleotide delivery, modified ribozymes, nuclease resistance, oligonucleotide uptake, cationic liposome formulations, antisense activity Key Phrases - Capitalized Phrases (CAPs): (learn more)
Nucleic Acids Res, New York, Antisense Res, Boca Raton, Cancer Res, Tetrahedron Lett, Bioconjugate Chem, Raven Press, Anti-Cancer Drug Design, Cell Biol, Semliki Forest, Academic Press, American Chemical Society, Biology of Antisense, Trends Biotechnol, Agents Chemother, Anticancer Drug Design, Cancer Inst, Drug Metab, Gene Ther, Liposome Res, Methods Enzvmol, New Biol, Nucleosides Nucleotides, Plenum Press New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
The ability to efficiently disrupt gene expression has become an important experimental approach for studying the biological function of a gene at the single-cell level and in intact organisms. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
hairpin loop domain, transgenic mouse cells, unmodified ribozyme, circular oligonucleotides, circular oligodeoxynucleotide, antisense oligoribonucleotides, oligonucleotides encapsulated, ribozyme expression, hybridizing arms, propyne pyrimidines, phosphodiester oligonucleotides, uptake enhancers, chimeric ribozymes, oligonucleotide derivatives, cytoplasmic delivery, oligodeoxynucleotide phosphorothioates, serum nucleases, phosphorothioate linkages, oligonucleotide transport, oligonucleotide delivery, modified ribozymes, nuclease resistance, oligonucleotide uptake, cationic liposome formulations, antisense activity Key Phrases - Capitalized Phrases (CAPs): (learn more)
Nucleic Acids Res, New York, Antisense Res, Boca Raton, Cancer Res, Tetrahedron Lett, Bioconjugate Chem, Raven Press, Anti-Cancer Drug Design, Cell Biol, Semliki Forest, Academic Press, American Chemical Society, Biology of Antisense, Trends Biotechnol, Agents Chemother, Anticancer Drug Design, Cancer Inst, Drug Metab, Gene Ther, Liposome Res, Methods Enzvmol, New Biol, Nucleosides Nucleotides, Plenum Press New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 16
books:
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2
books
cite this book:
- Antisense Research and Applications by Stanley T. Crooke on 4 pages
- Principles of Nucleic Acid Structure (Springer Advanced Texts in Chemistry) by Martin Egli on page 57, page 144, and page 172
- Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS by Eric Wickstrom on page 81, and page 278
- Antisense Strategies (Annals of the New York Academy of Sciences) by Renato Baserga on page 120, and page 279
- Nucleic Acids (Methods in Molecular Biology) by John M. Walker on page 230
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