This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.
Dermatotoxicology Methods
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Inside This Book
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First Sentence:
Formerly, healthy and intact skin was considered to be an impermeable barrier designed to shield the living organism from all types of environmental injury and offered protection from all things chemical. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
skin equivalent cultures, photomaximization test, pig allergy test, producing immunologic contact urticaria, cumulative contact enhancement test, elicited skin reactions, toxicology evaluation plan, phototoxicity studies, human skin cultures, phototoxicity testing, vitro skin toxicology, nonimmunologic immediate contact reactions, human skin responses, local lymph node assay, alternative method results, nonocclusive cover, nonirritant concentration, perfused porcine skin flap, test article administration, epidermal cell suspensions, clipped flank, receptor fluid, hairless guinea pig skin, lymph node dendritic cells, epidermal equivalents Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Prediction Model, Food Chem, Mary Ann Liebert, Dermatotoxicology Methods, Environmental Protection Agency, Testing Facility Laboratories, Study Director, Acta Derm, Boca Raton, Marcel Dekker, Ocular Toxicol, Academic Press, American College of Toxicol, Arch Dermatol, Cosmet Chem, Cancer Research, Department of Health, Toxicol Appl, Allergy Appl, Department of Transportation, Drug Metab, International Conference, National Academy of Sciences, Allergy Clin New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Formerly, healthy and intact skin was considered to be an impermeable barrier designed to shield the living organism from all types of environmental injury and offered protection from all things chemical. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
skin equivalent cultures, photomaximization test, pig allergy test, producing immunologic contact urticaria, cumulative contact enhancement test, elicited skin reactions, toxicology evaluation plan, phototoxicity studies, human skin cultures, phototoxicity testing, vitro skin toxicology, nonimmunologic immediate contact reactions, human skin responses, local lymph node assay, alternative method results, nonocclusive cover, nonirritant concentration, perfused porcine skin flap, test article administration, epidermal cell suspensions, clipped flank, receptor fluid, hairless guinea pig skin, lymph node dendritic cells, epidermal equivalents Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Prediction Model, Food Chem, Mary Ann Liebert, Dermatotoxicology Methods, Environmental Protection Agency, Testing Facility Laboratories, Study Director, Acta Derm, Boca Raton, Marcel Dekker, Ocular Toxicol, Academic Press, American College of Toxicol, Arch Dermatol, Cosmet Chem, Cancer Research, Department of Health, Toxicol Appl, Allergy Appl, Department of Transportation, Drug Metab, International Conference, National Academy of Sciences, Allergy Clin New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 8
books:
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- Models in Dermatology (Models in Dermatology, 4) by Howard I. Maibach on 4 pages
- Toxic Substances Control Act: Compliance/Enforcement Guidance Manual by Environmental Protection Agency on page 143
- Textbook of Contact Dermatitis by R. J. G. Rycroft on page 184
- Advanced Continuous Simulation Language (Acsl Reference Manual) by Mitchell on page 62
- Ultrasound in Liquid and Solid Metalstrasound in Liquid and Solid Metals by James G. Marks on page 158
See all 8 books this book cites
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