This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
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"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)
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This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.
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sequential and group sequential methods using Whitehead's triangular boundaries,
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This review is from: The Design and Analysis of Sequential Clinical Trials, 2.Rev.Ed. (Hardcover)
Whitehead has proposed a triangular stopping boundary that has optimal properties under certain assumptions for a fully sequential trial. The method can be extended to the group sequential approach but I believe it does lose its optimality properties. Jennison and Turnbull provide the best and most comprehensive text on group sequential methods. Whitehead present this approach and has software that he used to construct such a group sequential design. My colleague, Patrick Rojas, had the book and was considering the Whitehead design for one of his study trial. I don't think Whitehead's approach is anywhere near as popular as the family of models that is used in East. The East models include Pocock designs and O'Brien - Fleming as special cases and the Lan-DeMets alpha spending function approach is also available in East. None of this is available in Whitehead's software and none of these ideas are covered much in the book. That is why I prefer Jennison and Turnbull. Also East now has a lot of adaptive design capability.
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Inside This Book
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First Sentence:
Much of the statistical methodology currently used in the design and analysis of clinical trials has its origins in principles developed in the context of agricultural field trials during the 1920s. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
truncated sequential probability ratio test, double triangular test, fixed sample trial, full interim analysis, adjusted maximum likelihood estimate, primary patient response, experimental superiority, absolute treatment effects, tree adjustment, ith inspection, notes and further comments, stopping limits, random permuted blocks, group sequential tests, median unbiased estimate, sample size review, stochastic curtailment, repeated confidence intervals, biased coin designs, sequential clinical trials, discrete monitoring, restricted procedure, stopping boundaries, single categorization, delayed observations Key Phrases - Capitalized Phrases (CAPs): (learn more)
Experimental Control, Data Monitoring Committee, Deviance Model, Institute Inc, Total Success New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Much of the statistical methodology currently used in the design and analysis of clinical trials has its origins in principles developed in the context of agricultural field trials during the 1920s. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
truncated sequential probability ratio test, double triangular test, fixed sample trial, full interim analysis, adjusted maximum likelihood estimate, primary patient response, experimental superiority, absolute treatment effects, tree adjustment, ith inspection, notes and further comments, stopping limits, random permuted blocks, group sequential tests, median unbiased estimate, sample size review, stochastic curtailment, repeated confidence intervals, biased coin designs, sequential clinical trials, discrete monitoring, restricted procedure, stopping boundaries, single categorization, delayed observations Key Phrases - Capitalized Phrases (CAPs): (learn more)
Experimental Control, Data Monitoring Committee, Deviance Model, Institute Inc, Total Success New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 26
books:
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52
books
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- Handbook of Sequential Analysis (Statistics: A Series of Textbooks and Monographs) by B.K. Ghosh in Back Matter (1), and Back Matter (2)
- Decision Analysis: A Bayesian Approach (Chapman & Hall statistics texts) by J. Q. Smith in Back Matter
- Clinical Trials by Author Unknown in Back Matter
- Nonparametrics: Statistical Methods Based on Ranks by Erich L. Lehmann in Back Matter
- The Statistical Analysis of Failure Time Data (Wiley Series in Probability and Statistics) by John D. Kalbfleisch in Back Matter
See all 26 books this book cites
- Principles of Experimental Design for the Life Sciences by Murray R. Selwyn on 4 pages
- Handbook of Sequential Analysis (Statistics: A Series of Textbooks and Monographs) by B.K. Ghosh on 4 pages
- Statistical Monitoring of Clinical Trials: Fundamentals for Investigators by Lemuel A. Moyé on page 29, page 30, and page 142
- Meta-Analysis of Controlled Clinical Trials (Statistics in Practice) by Anne Whitehead in Back Matter (1), and Back Matter (2)
- Bayesian Approaches to Clinical Trials and Health-Care Evaluation (Statistics in Practice) by David J. Spiegelhalter in Back Matter (1), and Back Matter (2)
See all 52 books citing this book
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