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40 of 40 people found the following review helpful:
4.0 out of 5 stars
sequential and group sequential methods using Whitehead's triangular boundaries,
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This review is from: The Design and Analysis of Sequential Clinical Trials, 2.Rev.Ed. (Hardcover)
Whitehead has proposed a triangular stopping boundary that has optimal properties under certain assumptions for a fully sequential trial. The method can be extended to the group sequential approach but I believe it does lose its optimality properties. Jennison and Turnbull provide the best and most comprehensive text on group sequential methods. Whitehead present this approach and has software that he used to construct such a group sequential design. My colleague, Patrick Rojas, had the book and was considering the Whitehead design for one of his study trial. I don't think Whitehead's approach is anywhere near as popular as the family of models that is used in East. The East models include Pocock designs and O'Brien - Fleming as special cases and the Lan-DeMets alpha spending function approach is also available in East. None of this is available in Whitehead's software and none of these ideas are covered much in the book. That is why I prefer Jennison and Turnbull. Also East now has a lot of adaptive design capability.
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The Design and Analysis of Sequential Clinical Trials, 2.Rev.Ed. by John Whitehead (Hardcover - July 1997)
$170.00 $133.91
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