Drug discovery strategies for both pharmaceutical and agrochemical applications are at a stage of rapid development. More than 30 % of sales of drugs for human consumption worldwide are of plant origin. This unique book covers the present status and future potential of natural products in drug discovery. It provides the reader with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods. Because the renewed interest in the use of natural sources in drug discovery is an important supplement to combinatorial and parallel synthesis approaches, this book is timely and will have a great scientific impact.
Drug Discovery from Nature
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Drug discovery strategies for both pharmaceutical and agrochemical applications are at a stage of rapid development. More than 30 % of sales of drugs for human consumption worldwide are of plant origin. This unique book covers the present status and future potential of natural products in drug discovery. It provides the reader with recent information of regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods. Because the renewed interest in the use of natural sources in drug discovery is an important supplement to combinatorial and parallel synthesis approaches, this book is timely and will have a great scientific impact.
--This text refers to an out of print or unavailable edition of this title.
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Inside This Book
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First Sentence:
Although interest in natural products as a source of innovation in drug discovery has decreased in the last few decades, therapeutics of microbial or plant origin count for more than 30% of the current worldwide human therapeutics sales. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
biological derivatization, antibiotic biosynthetic gene clusters, natural product pool, chemical screening approach, antibiotic biosynthesis genes, combinatorial biocatalysis, hybrid antibiotics, new secondary metabolites, multiple parallel synthesis, semisynthetic modifications, helper enzymes, combinatorial biosynthesis, microbial secondary metabolism, prolyl isomerization, drug discovery strategies, screening attempts, actin skeleton, laboratory automation, prolyl bond, pool compounds, combinatorial synthesis, biosynthetic sequence, starter unit, industrial antibiotics, secondary metabolic pathways Key Phrases - Capitalized Phrases (CAPs): (learn more)
Tetrahedron Lett, New York, Angew Chem, Org Chem, Liebigs Ann Chem, Proc Natl Acad Sci, Biol Chem, Med Chem, Antimicrob Agents Chemother, Academic Press, Natural Product Pool, Hely Chim Acta, Nat Prod Rep, Annu Rev Microbiol, Chem Rev, Chem Soc Perkin Trans, Nature Biotechnology, Biochim Biophys Acta, Boca Raton, Chem Biol, Bristol-Myers Squibb, Chem Pharm Bull, Mol Gen Genet, Marcel Dekker, Mol Biol New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Although interest in natural products as a source of innovation in drug discovery has decreased in the last few decades, therapeutics of microbial or plant origin count for more than 30% of the current worldwide human therapeutics sales. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
biological derivatization, antibiotic biosynthetic gene clusters, natural product pool, chemical screening approach, antibiotic biosynthesis genes, combinatorial biocatalysis, hybrid antibiotics, new secondary metabolites, multiple parallel synthesis, semisynthetic modifications, helper enzymes, combinatorial biosynthesis, microbial secondary metabolism, prolyl isomerization, drug discovery strategies, screening attempts, actin skeleton, laboratory automation, prolyl bond, pool compounds, combinatorial synthesis, biosynthetic sequence, starter unit, industrial antibiotics, secondary metabolic pathways Key Phrases - Capitalized Phrases (CAPs): (learn more)
Tetrahedron Lett, New York, Angew Chem, Org Chem, Liebigs Ann Chem, Proc Natl Acad Sci, Biol Chem, Med Chem, Antimicrob Agents Chemother, Academic Press, Natural Product Pool, Hely Chim Acta, Nat Prod Rep, Annu Rev Microbiol, Chem Rev, Chem Soc Perkin Trans, Nature Biotechnology, Biochim Biophys Acta, Boca Raton, Chem Biol, Bristol-Myers Squibb, Chem Pharm Bull, Mol Gen Genet, Marcel Dekker, Mol Biol New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 11
books:
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13
books
cite this book:
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- Drug Discovery from Nature by S. Grabley in Front Matter (1), and Front Matter (2)
- Clinical Immunology by Post Grad Committee Vet Sci on page 280
- Cell Biology (Molecular and Cell Biochemistry Series) by C. A. Smith on page 280
- Biotransformations in Organic Chemistry: A Textbook by Kurt Faber on page 213
- Phytochemicals for Pest Control by Paul A. Hedin on page 177
See all 11 books this book cites
- Modern Methods of Drug Discovery by Alexander Hillisch on page 105, and page 106
- What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century by Jean Swingle Greek on page 88, and Back Matter
- Biotransformations (Springer Desktop Editions in Chemistry) by K. Faber in Front Matter
- Natural Products in the New Millennium: Prospects and Industrial Application (Proceedings of the Phytochemical Society of Europe) by Amélia Pilar Rauter on page 363
- High Throughput Screening: Methods and Protocols (Methods in Molecular Biology) (World's Best Reading) by William P. Janzen on page 168
See all 13 books citing this book
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