Prion Diseases and Copper Metabolism BSE,Scrapie, and CJD Research [Hardcover]

David Brown (Author)

Book Description

Publication Date: February 1, 2004

International authorities here investigate recent research into the prion diseases which include Scrapie of sheep, BSE the Mad Cow disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer's disease. The book focuses on metabolism of copper and manganese which are found in these diseases. It stems from proceedings of the international workshop at Christ's College, Cambridge University in 2001. After an introduction on the history of research into the diseases, there are discussions on the affects of copper on biochemical properties and prion proteins of brain cells, and new techniques for their study. There is also a section on the relationship of Alzheimers disease to prion diseases.

Editorial Reviews

Review

"The best prion book ever! ...a very well researched and prepared book on the neurodegenerative conditions known as prion diseases or TSEs. …if you want an introduction to the prion diseases as a student or are a professional looking for a readable and relevant update - this is the book for you." -

Review by a customer on Amazon.co.uk

About the Author

David Brown, University of Bath, UK

Product Details

• Hardcover: 250 pages
• Publisher: Woodhead Publishing (February 1, 2004)
• Language: English
• ISBN-10: 189856387X
• ISBN-13: 978-1898563877
• Product Dimensions: 9.4 x 6.8 x 0.8 inches
• Shipping Weight: 1 pounds (View shipping rates and policies)
• Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
• Amazon Best Sellers Rank: #5,004,624 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

1 of 2 people found the following review helpful:

5.0 out of 5 stars The best prion book ever!!!!, August 4, 2005

By 

fukaguzzi (USA) - See all my reviews

This review is from: Prion Diseases and Copper Metabolism BSE,Scrapie, and CJD Research (Hardcover)

This is a very well researched and prepared book on the neurodegenerative conditions known as prion diseases or TSEs. It focuses on a particular aspect, the metal binding capacity of the protein at the heart of these diseases, the prion protein. As such this finding links the research to the many other neurodegenerative diseases that have also been linked to metals. These diseases include Alzheimers and Parkinsons disease. This is brought out in the book. David Brown had been at the forefront of this kind of research for many years and his sections of the book are clearly the best. Contributions from other authors are also present and good. Unlike other books on this subject, this one is refreshingly unbiased and remains an up-to-date account of the field. It is very molecular which makes it more like "hard science" too many of these books are filled with hundred of pages of brain sections or descriptions of how the researchers extrapolate from dead mice to human disease. If you want an introduction to the prion diseases as a student or are a professional looking for a readable and relevant update - this is the book for you!!
PS: By the way my copy is a hardback!!!