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Diversity in the Neuronal Machine: Order and Variability in Interneuronal Microcircuits 0th Edition

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ISBN-13: 978-0195177015
ISBN-10: 0195177010
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Editorial Reviews

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"Every so often, a book or monograph comes along whose timing is impeccably linked to the blossoming and maturation of a research field; Diversity in the Neuronal Machine is one such book.this is a book with tremendous depth and critical thinking and in short it is a tremendously satisfying read.I would urge anyone who feels that they have something to say about interneuron classification schemes to read it and carefully consider the arguments set forth."--Chris J. McBain, Laboratory of Cellular and Synaptic Neurophysiology at the National Institute of Child Health and Human Development, in Neuron


"Every so often, a book or monograph comes along whose timing is impeccably linked to the blossoming and maturation of a research field; Diversity in the Neuronal Machine is one such book."--Neuron


"Dr. Soltesz writes with a clear and entertaining style that keeps the reader's interest throughout."--The Journal of Chemical Neuroanatomy


About the Author

Ivan Soltesz is at University of California, Irvine.

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Product Details

  • Hardcover: 264 pages
  • Publisher: Oxford University Press (November 10, 2005)
  • Language: English
  • ISBN-10: 0195177010
  • ISBN-13: 978-0195177015
  • Product Dimensions: 9.3 x 0.9 x 6.3 inches
  • Shipping Weight: 1.6 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Best Sellers Rank: #2,886,724 in Books (See Top 100 in Books)

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6 of 6 people found the following review helpful By Ebrahim Mayat on July 10, 2007
Format: Hardcover
"Diversity in the Neuronal Machine" provides valuable insights into the topic of interneurons (formally classified by the author as "using GABA as its primary fast neurotransmitter in the normal, non-pathological state") as opposed to the principal excitatory projection neurons of the nervous system. Beginning with the studies and hypotheses of the Nobel laureate Santiago Ramon y Cajal, Dr Soltesz explores the roles of "the so-called neurons with short axons..." as the "elemental components" of cerebral activity.

Interneuronal complexity is clearly explained by an in-depth evaluation of several classification schemes that demonstrate the existence of a large variety of interneuronal types. This leads the author to propose a statistical quantification of interneuronal diversity. The question of whether this diversity could explain the evolution of higher intelligence is addressed by the novel applications of network theory to neuronal microcircuit function. Using both mammalian and invertebrate models and computer simulations as examples, Cajal's hypotheses on functional neuroanatomy are extended to incorporate cell-to-cell interneuronal variability as an important factor in the study of interneuronal heterogeneity.

In all, this book provides a compelling insight into the relatively unexplored subject of interneurons and their physiological and even evolutionary significance. An added bonus is the inter-disciplinary nature of this book which opens the neuroscientist to novel insights emanating from the fields of computer modeling, network theory and even artificial intelligence. Fascinating reading!!!
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Format: Hardcover
Addresses the diversity of interneuronal populations and implications for functional relationships. Relates the topic to network/information theory. Opens up interesting possibilities.
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