Doctor's Best - Best 5-Htp, 100mg, 60 capsules

by Doctor's Best

Product Features

• 60 Capsules
• Serving Size: 1 capsule
• 60 Servings Per Container

Product Description

5-HTP (5-hydroxytryptophan) is a naturally-occurring metabolite of the essential amino acid tryptophan. 5-HTP for use in dietary supplements is derived from the seeds of the Griffonia simplicifolia plant. Metabolism and absorption of 5-HTP 5-HTP (5-hydroxytryptophan) is formed by the addition of a hydroxyl group (-OH) to the 5 carbon of the indole ring of tryptophan. Conversion of tryptophan to 5-hydroxytryptophan is catalyzed by the enzyme tryptophan hydroxylase.1 5-HTP functions as the precursor for serotonin, and is converted to serotonin in a pyridoxal phosphate (vitamin B6) dependent reaction catalyzed by the enzyme L-amino acid decarboxylase.2 Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including nutritional status and competition between tryptophan and other amino acids for transport across the blood brain barrier. Disturbances in the serotonin metabolic pathway may disrupt central nervous system functions which utilize serotonin as a neurotransmitter.2 Administration of 5-HTP bypasses the conversion of tryptophan to 5-HTP. 5-HTP readily crosses the blood brain barrier and becomes available for serotonin synthesis. Serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep, appetite, nociception (the perception of pain), and aggressive behavior.2 Serotonin is metabolized to 5-HIAA (5-hyd

Product Details

• Item Weight: 1.3 ounces
• Shipping Weight: 1 pounds (View shipping rates and policies)
• ASIN: B000BD2KBI
• UPC: 753950000773
• Average Customer Review: 2.0 out of 5 stars  See all reviews (1 customer review)
• Amazon Best Sellers Rank: #168,097 in Health & Personal Care (See Top 100 in Health & Personal Care)

Customer Reviews

Most Helpful Customer Reviews

2.0 out of 5 stars unfortunately this did not work for me but...., January 13, 2012

By 

Desert Gypsy "A Brooklyn Girl Out West" (Southern Utah, USA) - See all my reviews
(TOP 1000 REVIEWER)   

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This review is from: Doctor's Best - Best 5-Htp, 100mg, 60 capsules (Health and Beauty)

this supplement *could* be something to try if you have had problems with sleep or migraines. Research is promising in both areas but after two months on this supplement I did not notice any significant difference in my sleep, or *lack* there of as the case may be and no reduction in frequency or intensity of my migraines. Everyone's system will respond differently so my experience will obviously be different from anyone else's; even though my result was not great and 1-2 star reviews are never "popular" I feel it's best to add the result here since many people count on information like this to make an informed purchasing decision.

I recently tried NOW Foods Gaba 750mg, 100 Vcaps to help manage my chronic insomnia and I had really great results with that particular supplement.

Regarding the 5-HTP, GABA or *any* supplement I'd have to say that as long as you have your physician's knowledge and consent, that what is SAFE and affordable is probably worth a try.