OK, I have read the manual and read LOTS of online reviews and my answer would be it is NOT recommended for cardstock. People who HAVE run cardstock through it have eventually had trouble with the rollers not grabbing. There is a 'mode' for "Epson Presentation Paper - Heavyweight Matte" which is #44. The cardstock I have is #65. IF you need to run primarily cardstock, I would advise against it. OR be sure to change the setting to the Presentation Paper mode. If you can get by with a 44 pound weight paper, then it seems that this printer can handle it. I would guess an occasional piece of cardstock won't kill it but if you primarily print cardstock you might want a more robust printer. Hope this helps! PS. I usually use a high quality paper to print normal copies and it's #22 - just for comparison.