Drug Discovery and Evaluation: Pharmacological Assays (Book with CD-ROM) [Hardcover]

Gerhard Vogel (Author), Wolfgang H. Vogel (Author), H. Gerhard Vogel (Author)

Book Description

ISBN-10: 3540602917 | ISBN-13: 978-3540602910 | Publication Date: January 15, 1997 | Edition: Bk&CD-Rom

This reference work contains a selection of frequently used assays for detecting pharmacological effects of potential drugs including cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the assays - of which there are over 700 - comprises a detailed protocol with the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. Identification of specific tests is facilitated by the accompanying CD-ROM which allows for a quick text research. An appendix sets out guidelines and legal regulations for animal experiments in various countries.

Editorial Reviews

From Publishers Weekly

安全性の問題は新薬の創製・開発プロセスにおいて懸案になっていいる.15年前まで、創薬と薬物評価は、新規合成化合物の薬理評価で最も高活性の化合物を選択することに始まる逐次プロセスであった. しかし逐次プロセスは様々な理由により過去のものとなっており、また、製薬業界における新薬開発の成功率や年間の新薬発売数が急激に落ち込む一方で新規化合物の開発に要する期間は延びている.その間に特許の満了を迎えてしまうこともあり、そのため、開発ストラテジーが変わってきている.さらに毒性学は、コンピュータシミュレーション法やトキシコゲノミクス、トキシコプロテオミクスなどの新しい手法が導入され、大きく飛躍した.本書は、新薬開発をめぐる環境が変わりゆくなかでの画期的な解説書である.薬理学や毒性学を学ぶ学生だけでなく、とくに新薬の臨床試験に関わる医師や、医薬品の安全用件を理解しておかねばならない薬剤師、新薬の探索・開発に携わり開発プロセスにおいて意思決定を行う製薬業界の研究者や幹部などに極めて有用な情報を提供する.さらに、世界的に共通の薬物評価ガイドライン作成に関わっている政府機関・委員会の方々にも大いに役立つであろう.
Copyright© Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. --This text refers to an alternate Hardcover edition.

Review

From the reviews of the second edition:

"Pharmacological studies are a pivotal but sometimes neglected area … . Failure to evaluate your candidate compound in appropriate models will greatly reduce your chances of success … . This excellent reference book will assist you in avoiding this fate. … Although the update has increased the book from around 750 to 1400 pages, it is still indexed in a clear, concise way making access to each assay easy. … I would thoroughly recommend this book. … it is a well-worth, long term investment." (Paul Baldrick, British Toxicology Society Newsletter, Issue 20, 2002)

"The second edition of ‘Drug Discovery and Evaluation’ presents an expanded and updated version of one of the classic reference handbooks on pharmacological assays. … Each assay description is sufficiently outlined and equipped with outstanding literature references. … A newly included CD-ROM provides easy identification of tests, guidelines and even legal regulations for animal experiments. … This comprehensive classical reference handbook mainly addresses the needs of pharmacological institutes and research groups working in this area." (Dr. Jürg Gertsch, BioWorld, Issue 2, 2003)

--This text refers to an alternate Hardcover edition.

See all Editorial Reviews

Product Details

• Hardcover: 757 pages
• Publisher: J. A. Majors Company; Bk&CD-Rom edition (January 15, 1997)
• Language: English
• ISBN-10: 3540602917
• ISBN-13: 978-3540602910
• Product Dimensions: 11 x 8.2 x 1.5 inches
• Shipping Weight: 4.2 pounds
• Average Customer Review: 4.0 out of 5 stars  See all reviews (2 customer reviews)
• Amazon Best Sellers Rank: #4,588,191 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews

3.0 out of 5 stars Well constructed and potentially useful, September 15, 2005

By 

Douglas Standing (Sunnyvale, CA USA) - See all my reviews
(REAL NAME)   

This review is from: Drug Discovery and Evaluation (Hardcover)

I have the 2nd edition of this reference, obtained in 2003. Springer-Verlag and their printers have done a very nice job of making this large (1400-page) book, and they provide a very readable typeset. The text is laid out in numerous short application notes describing different pharmacological assays, and these include sections on the study's purpose, a paragraph on the procedure, another on the approach to interpreting results, a fourth cursory section discussing modifications of the method by others, and a usually generous list of references after that. A big plus, I think, is the inclusion of a CD-ROM that contains an Adobe PDF of the entire text. This is a better medium in which to do searching, especially since the hardcover's printed lookup is set up in such extensive run-in indexing, with numerous cascades of indented em-dashes on subentries that it is really kind of annoying. The Contents list, grouped by organ systems, is a lot more useful.

It's still a difficult call making a decision to recommend a text like this - if you are actively doing pharmacological research, your sources are probably more current at your bench, or in recent journals and meetings. But, the very readable structure, many references, and a useful CD-ROM, suggests Vogel's text as an appealing and well-assembled package for academic and group reference.

0 of 3 people found the following review helpful:

5.0 out of 5 stars A wonderful book for pharmacological Researchers, June 29, 2000

By 

gaurang shah (Gujarat, INDIA) - See all my reviews

This review is from: Drug Discovery and Evaluation: Pharmacological Assays (Book with CD-ROM) (Hardcover)

The book is a wonderful addition to books on drug evaluation. I feel pharmacologists are getting very few books on this subject. This book can end up the search for such pharmacologists. It will surely boost the research in this field. I hope that this book should reach into hands of every pharmacologists. Whether he/she is a academician or researcher, this book will be a valuable addition to his/her personal library. Each institute conducting research or teaching in pharmacology should also have this book in the library.

Many thanks to the authors and publishers of this books.