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Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization Hardcover – February 19, 2008

ISBN-13: 978-0123695208 ISBN-10: 0123695201 Edition: 1st

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Product Details

  • Hardcover: 552 pages
  • Publisher: Academic Press; 1 edition (February 19, 2008)
  • Language: English
  • ISBN-10: 0123695201
  • ISBN-13: 978-0123695208
  • Product Dimensions: 1.4 x 7.5 x 10.2 inches
  • Shipping Weight: 3 pounds (View shipping rates and policies)
  • Average Customer Review: 4.7 out of 5 stars  See all reviews (7 customer reviews)
  • Amazon Best Sellers Rank: #345,183 in Books (See Top 100 in Books)

Editorial Reviews

Review

JOURNAL OF MEDICINAL CHEMISTRY, OCTOBER 2008: "The authors do an excellent job of providing insight into the background of the many factors that influence drug-like properties...[This] easy-to-read text is...an excellent addition to the library of practicing medicinal chemists and of graduate students in the pharmaceutical sciences. It provides a wealth of information for a reasonable price."--Thomas E. Prisinzano, Dept. of Medicinal Chemistry, University of Kansas, KS, USA

DOODY'S, SEPTEMBER 2008: "This is a valuable reference for any scientist who works as part of a drug discovery team and especially those who are involved in ADME to toxicity optimization [.] The authors have done a nice job of presenting this information in a concise, readable format.”--Thomas Pazdernik, University of Kansas Medical Center, KS, USA

"[Recently] I bought your excellent book, and I want to congratulate you and thank you for injecting life into the science of ADMET, lifting the subject to 'bestseller,' enjoyable reading material. It is the best book that I have come across that makes a great job of fostering collaborative interactions between ADMET and Medicinal Chemistry scientists in advancing strategies of drug discovery.”--Dr. Collen Masimirembwa, Chief Scientific Officer, AiBST

"I am very impressed...[The book] is destined to become an authoritative text on the whole topic area of drug-like molecules and ADME screening. The chapters are well written and include sufficient detail and references so that the reader can make use of the information effectively. The book could be used in a graduate-level course for medicinal chemists or DMPK scientists. The book would also be very helpful for scientists working in one area of DMPK who wish to become DMPK project managers and need to increase their understanding of other areas of DMPK that are outside of their own specific expertise function. The chapter on pharmacokinetics provides a very good overview of the topic. This book is well worth the purchase price." --Walter Korfmacher, NJ, USA

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Customer Reviews

4.7 out of 5 stars
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See all 7 customer reviews
This book gave me most of the answers I needed in a very short amount of time.
M. Johnson
Overall this is a great book and would be especially useful for organic/medicinal chemistry doctoral/post-doctoral students.
Eric Ballard
The chapter on pharmacokinetics was well written and provides a very good overview of the topic.
Walter Korfmacher

Most Helpful Customer Reviews

8 of 9 people found the following review helpful By Walter Korfmacher on February 23, 2008
Format: Hardcover
I have spent some of the last two days reading this book and I am very impressed with it. It is destined to become an authoritative text on the whole topic area of drug-like molecules and ADME screening. The chapters are well written and include sufficient detail and references so that the reader can make use of the information effectively. The book could be used in a graduate-level course for medicinal chemists or DMPK scientists.
The book would also be very helpful for scientists working in one area of DMPK who wish to become DMPK project managers and need to increase their understanding of other areas of DMPK that are outside of their own specific expetise function. The chapter on pharmacokinetics was well written and provides a very good overview of the topic. Overall, I can state that this book is well worth the purchase price.
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1 of 1 people found the following review helpful By Eric Ballard on February 8, 2010
Format: Hardcover
This is quite simply a very impressive text and was great from the first to the last page. The introductory chapters adequately acquaint(or re-acquaint) the reader with concepts of drug-likeness and barriers to a successful drug. Topics covered in the intro chapters are then explained in great detail in individual chapters making the text very easy to follow and extremely informative. The later portion of the book describes methods used to assay and/or solve particular ADME/Tox issues and isn't necessarily useful to the non-practitioner but is definitely a go-to source if one needs this information. Also noteworthy are the problems at the end of each chapter that do a fairly good job of summarizing and applying the key topics learned in the chapter and answers are included in the appendix for reference. Overall this is a great book and would be especially useful for organic/medicinal chemistry doctoral/post-doctoral students.
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1 of 1 people found the following review helpful By Big Chucko on August 1, 2009
Format: Hardcover
This book contains a wealth of information concerning a number of topics of special interest to medicinal chemists in the pharmaceutical or animal science business. On many occasions I have sought and found useful information in this book - it serves as a very good primary source for basic information related to many aspects of preclinical drug discovery. This book fills a great void and should find its way onto the desk of any medicinal chemist who wants to learn more about understanding and manipulating the pharmaceutical properties of their compounds. Highly recommended!!
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1 of 1 people found the following review helpful By Carlos Mateos Gutierrez on March 28, 2009
Format: Hardcover
It is very nice overview of the practical topics for the practicing medicinal chemist.
For the just arrived synthetic chemist, it represents a way of looking not so puzzled in project meetings when interacting with experienced collegues.
For senior drug-hunters, it is a guide to check for clear understanding of drug properties in the selection and optimization of new leads. Emphasis is placed on the methods for measuring properties using high throughput, diagnostic and in-depth methods.
In a nutshell, a very useful learning material for scientists engaged in drug discovery and a reference for regular use.
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