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Epigenetics: The Ultimate Mystery of Inheritance [Hardcover]

Richard C. Francis
4.0 out of 5 stars  See all reviews (38 customer reviews)

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Book Description

June 13, 2011 0393070050 978-0393070057

Time to worry again—our lifestyle choices do impact our genetic code and that of our children (and even grandchildren!).

"The potential is staggering. . . . The age of epigenetics has arrived."—Time, January 2010

Epigenetic means "on the gene," and the term refers to the recent discovery that stress in the environment can impact an individual's physiology so deeply that those biological scars are actually inherited by the next several generations. For instance, a recent study has shown that men who started smoking before puberty caused their sons to have significantly higher rates of obesity. And obesity is just the tip of the iceberg—many researchers believe that epigenetics holds the key to understanding cancer, Alzheimer's, schizophrenia, autism, and diabetes.

Epigenetics is the first book for general readers on this fascinating and important topic. The book is driven by stories such as the Dutch famine of World War II, José Canseco and steroids, the breeding of mules and hinnies, Tazmanian devils and contagious cancer, and more. 18 illustrations

Frequently Bought Together

Epigenetics: The Ultimate Mystery of Inheritance + The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance + Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life (Life and Mind: Philosophical Issues in Biology and Psychology)
Price for all three: $55.75

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Editorial Reviews

Review

"The potential is staggering... The age of epigenetics has arrived." Time, January 2010

About the Author

Richard C. Francis is a writer who has a PhD in biology from Stony Brook University. He is the author of Why Men Won't Ask for Directions. He lives in New York City.

Product Details

  • Hardcover: 234 pages
  • Publisher: W. W. Norton & Company (June 13, 2011)
  • Language: English
  • ISBN-10: 0393070050
  • ISBN-13: 978-0393070057
  • Product Dimensions: 9.5 x 6.4 x 0.9 inches
  • Shipping Weight: 1.2 pounds (View shipping rates and policies)
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (38 customer reviews)
  • Amazon Best Sellers Rank: #679,630 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews
64 of 69 people found the following review helpful
3.0 out of 5 stars High hopes, but was disappointed July 26, 2011
Format:Hardcover
There is definitely a market for a good popular science book about epigenetics, and I eagerly awaited this one. But it fell short of my expectations. It simply is too short, and too lacking in depth. For the epigenetics of inheritance and evolution, there already is an excellent book out there: Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life (Life and Mind: Philosophical Issues in Biology and Psychology) . However, the book by Jablonka & Lamb is getting a little old (in this field, things sure develop rapidly), and it lacks the issues that I was most interested in - the effects of epigenetic change on health. However, I'll restate, for the evolutionary side, the Jablonka & Lamb book is great.

Back to the book by Francis, 160 pages is just too short. I will acknowledge the great many notes and large bibliography included, but the first 160 pages are so superficial, I doubt the author finds the right audience for the notes/bibliography.

The author's writing style and explanations are fine, so if you want a quick overview on a topic of which you have zero knowledge before, this book will serve you well.
However, for many of us, we must wait for a book with more depth, or a vastly expanded second edition.

For an example of excellent and in depth popular science writing, try Power, Sex, Suicide: Mitochondria and the Meaning of Life.
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41 of 46 people found the following review helpful
5.0 out of 5 stars Engaging epigenetics June 21, 2011
Format:Hardcover
This is a fascinating introduction to the new field of Epigenetics - a word to which most people react blankly. Most have no idea what how epigenetics changes the way that we conceptualize human development and inheritance, as well as conditions ranging from cancer to Alzheimer's disease.

Francis starts each chapter with a well-chosen, true story or observation that serves to illustrate the main points of that chapter. Frequently he circles back to the information presented in earlier chapters and it is clear that he is slowly building, in completely understandable terms, the reader's ability to understand the implications and intricacies of this burgeoning field of study, culminating in an outstanding discussion of stem cells.

From the Dutch famine of World War II to the growing obesity crisis to the fact that the experience of past generations can influence the current one - and the scary thought that what we do and experience will also have ramifications for future generations - the book is well-written, witty, and very timely. Don't be surprised if you start to read and can't stop until you are done!
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16 of 17 people found the following review helpful
4.0 out of 5 stars Readable epigenesis October 6, 2011
Format:Hardcover|Verified Purchase
This is a pretty accessible treatment of a somewhat arcane topic for non-biologists. It is probably too advanced for the totally lay reader, but for a person willing to make the effort to understand what is being said, it is really important. Epigenetics is one of the most important avenues for understanding many of our modern maladies (e.g. diabetes, cancer), and will eventually lead to new and more effective treatment regimens for many conditions. This work presents the basic ideas of epigenesis pretty clearly. In my mind it doesn't go far enough to detail what the processes are that result in its implications. However, it is a start.
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16 of 21 people found the following review helpful
4.0 out of 5 stars Epigenetics 101 May 29, 2012
Format:Paperback|Verified Purchase
As a basic beginner's treatise on the emerging science of epigenetics, I recommend this book. I was hoping for more concrete examples of epigenetic changes than what was presented, but overall, it is an excellent book to read before one goes on to read more in-depth about this subject matter.
Additionally, this book fails to recognize the abslutely ground-breaking phenomenal implications of epigenetics to the field of genetics which is emerging at breakneck speed.
To draw an analogy, genetics is the score, epigenetics the symphony.
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10 of 13 people found the following review helpful
3.0 out of 5 stars Nice overview, but don't expect explanations August 21, 2012
By crik
Format:Paperback
This book gives a nice overview on WHERE epigenetics plays a role. On the one hand it looks on the effects of diet, stress and other environmental factors on long-term gene regulation, and on the other hand it explored how epigenetic regulation is influencing many aspects of our lives from obesity to disease outcome. It fails however in clearly explaining HOW this happens. I doubt anybody not yet familiar with the subjects remembers after the reading how all this works with methylation, histones etc.

Most chapters start with a look back on some important researchers and their findings and then explore what role epigenetics played in their experiments. Thus the book gives also some nice insights into the history of biological research. Unfortunately, in some cases the author decided to start instead with lengthy descriptions of a movie, just to stress out that people react differently to stress, or with personal thinkings on Thai diets. These parts are weak, and it is surprising that the author could not find more scientific examples to explain his ideas.

The book fails also to explore the ethical consequences of epigenetics. Obviously, if we learn that our behavior today such as smoking or exposure to stress will affect our grand children, this will have huge ethical implications. Ethical issues are discussed briefly in the context of embryonic stem cells, but this discussion is very poor (e.g. constantly mixing up religious and ethical grounds), and the book clearly lacks to highlight the full complexity of questions coming up.

Given that the book is only 160 pages long and one can read it quit fast, I still recommend it to anybody interested in a first overview on the subject.
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Most Recent Customer Reviews
4.0 out of 5 stars Epigenetics seems like a plausible way for a species to incrementally...
Epigenetics seems like a plausible way for a species to incrementally adapt to a changing life situation. Read more
Published 8 days ago by Blake C. Lawless
4.0 out of 5 stars Informative
Nice read. Chissles down some of the complexity of the gene-epigenetic world that we are just now learning. Read more
Published 2 months ago by chris moreno
4.0 out of 5 stars A Great Introduction to Epigenetics, but...
Review

When I was but a young man, so many moons ago, I used to delight in annoying my oh-so enlightened scientistic brethren by doubting that the current Darwinist... Read more
Published 3 months ago by Joseph Martin
5.0 out of 5 stars Epigenetics is a serious breakthrough in understanding how to cure...
I appreciated Francis’ treatment of the medical implications of epigenetics. Since reading it, I have looked at a few online medically-oriented articles on epigenetics to learn... Read more
Published 3 months ago by Jon Covey
4.0 out of 5 stars Great intro for the uninitiated.
I enjoyed reading this book. The author does a good job of introducing an advanced concept to give the reader an informed picture of the science of epigenetics and the complexities... Read more
Published 3 months ago by N. Walp
4.0 out of 5 stars clearly written and aimed at the level of the intelligent layperson
This is a novel and hard area to make accessible to those without insider knowledge but Richard Francis has done a good job. Read more
Published 5 months ago by Dr. Kenneth P. Nunn
4.0 out of 5 stars Wonderfully informative
A well written explanation of genetics as well as epigenetics. I would liked it to have been longer, but then that probably reflects how much I enjoyed it. Read more
Published 5 months ago by Roger Holtum
5.0 out of 5 stars A good Epigenetic overview
This book helps us change the way we think about genes, what they are and what they do. Excellent for leading one into deeper study into this fascinating science.
Published 5 months ago by Phyllis F Elmore
5.0 out of 5 stars Epigenetics
It's very informing. There are a lot of good facts on Epigenetics, enough to get a beginner interested in genetics and continue to study farther in depth.
Published 5 months ago by Eryn Sale
1.0 out of 5 stars A disappointment even before it was read
This book was a disappointment as soon as it was unpacked. The production is shoddy; the cover is flimsy but even worse it has a tacky feel which is most unpleasant to handle. Read more
Published 5 months ago by Sheila Ramsay
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