* A new method to measure deficiencies of Essential Fats (EFs). Using this patented method to analyze blood samples from the Framingham Heart Study and hundreds of patients, Dr. Siguel found that more than 25% of the adult US population has w6 deficiencies, and more than 50% has w3 deficiencies, reversing currently held beliefs that these conditions were rare (Siguel EN, Maclure, M. Relative Enzyme Activity of Unsaturated Fatty Acid Metabolic Pathways in Humans. Metabolism, 36: 664-669, 1987).
* How Essential Fats are the key missing link between nutrition and heart disease (Siguel E, Lerman, RH. Fatty Acid Patterns in Patients With Angiographically Documented CAD. Metabolism 1994; 43:982-993.) Contrary to then prevailing views, Siguel's research found that avoiding fat and replacing the calories with carbohydrates would not prevent heart disease. Instead, reducing caloric intake and eating a proper balance of Essential Fats was the key to prevent heart disease. His findings were validated by many studies, including a Harvard report. (Hu et al. Dietary Fat Intake and the Risk of CHD in Women. NEJM 1997, 337(21): 1491-9).
* Why EFs are the most likely nutritional factor that affects Total/HDL cholesterol, and how people can optimize their diet to reduce their risk for heart disease (Siguel, E. A New Relationship between PUFAs and TC/HDLC. Lipids, 1996; 31, S51-S56). * How Essential Fat abnormalities contribute to the complications of Crohn's disease, ulcerative colitis, cystic fibrosis, and other chronic intestinal diseases (Siguel E, Lerman, RH. Fatty Acid Patterns in Patients with Chronic Intestinal Disease. Metabolism. 1996; 45(1):12-23); using nutritional supplements to correct these conditions.
* The role of Essential Fats, vegetarian diets and antioxidants in breast and prostate cancer. Siguel provides a biochemical explanation of how vegetarian diets can treat cancer, and gives new approaches using Essential Fats to reduce cancer cell reproduction (making cancer cells more unstable through modification of membrane fluidity) (Siguel EN. Cancerostatic Effect of Vegetable Diets. Nutrition and Cancer, 4:285-289, 1983).
* New diagnostic and treatment methods for diabetes.
* How low-fat diets can cause essential fat abnormalities and lead to premature heart disease, behavioral and learning difficulties, and many other problems (Siguel E, Lerman RH. The Effects of Low-Fat Diet on Lipid Levels. JAMA, 1996; 275:759. Siguel E, Lerman RH, MacBeath, B. Very Low-Fat Diets for CHD: Perhaps, But Which One? JAMA, 1996:275: 1402-1403. Siguel, E. Dietary Fat: How Low Can or Should You Go? Symposium, AOCS Annual Meeting, 1997).
* The role of functional foods in preventing and treating disease (Siguel, E. Issues and Problems in the Design of Foods Rich in EFAs. Lipid Technology, 8(4):81-86, 1996).
* Optimized drug and nutrition therapies for people who have abnormal lipids and increased risk of premature death due to cardiovascular disease.
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Most Helpful Customer Reviews
22 of 22 people found the following review helpful:
5.0 out of 5 stars
Engaging presentation of important nutritional subject.,
By A Customer
This review is from: Essential Fatty Acids in Health & Disease : Using the Essential Fats w3 and w6 to Improve Your Health, Lower Your Cholesterol, and Prevent Cardiovascular Disease (Paperback)
"Essential Fatty Acids in Health & Disease" by Edward N. Siguel, I was lucky to find this book before it was listed here at Amazon.com. It is not promoted by a major publisher so I would not have seen it in bookstores. I was searching the Web and found the Web site of the author describing this book and the research it is based on. Since then I have given away several copies as gifts. Although the author is M.D. and Ph.D., and did original research on essential fatty acids, he has a sense of humor and the book is very readable and entertaining. It has some sections where you will find more medical terminology, but those sections are clearly marked "For health professionals" and you may skip them. Dr. Siguel developed a test for measuring amounts of fatty acids in the blood. He used that test to analyze the blood of healthy people and people with wide variety of diseases. He noticed that people with a disease had fatty acids in different proportions than healthy people. It appears that one necessary condition for restoring health is restoring the healthy balance of fatty acids. The book starts by comparing types of fats: saturated, monounsaturated and polyunsaturated. It explains the term essential fatty acids. I must confess my ignorance. I did not know that anything in fats was essential for life. I new about essential amino acids but not about essential fatty acids. In both cases the name essential identifies those acids that our body can't make from other ingredients. To sustain life we must get them from food. Further, the book divides essential fatty acids into two groups, known as omega-3 and omega-6 fatty acids. It describes functions of fatty acids in both groups. It describes effects of both groups on many serious diseases with more emphasis on heart disease. I find the part that describes nutritional requirements for disease prevention even more important than the discussion of specific diseases. This describes the healthy balance of fatty acids and how to achieve it. It compares the fatty acid composition of oils available on the market: vegetable oils and fish oils. It gives hints on how to find quality oil and what to avoid. It deals with misconceptions about fats and cholesterol. It describes other nutrients required for proper utilization of fats and healthy nutrition in general. It warns about unnaturally modified fats in processed foods. This is where I first found the explanation of the terms trans-fatty acids and hydrogenated oils, why I should not eat anything that contains them, and how the ingredients list on the package will not always tell me about them. Based on the results of his research, Dr. Siguel criticizes USDA Food Pyramid which places fats at the top and suggests that all fats should be used sparingly. He also gives some unique insights on medical research and the practice of medicine. This book had made me curious to learn more about the role of fats in supporting human life, the subject I was so ignorant about. I have found more books that debunk the notion, until recently so fashionable, that all fat is bad. I found that different authors promote different types of fat. Many recommend mainly monosaturated oils like olive and canola. However they do not support that recommendation by the analysis of those oils or by the explanation of their role in human metabolism. This book recommends polyunsaturated oils because only they contain the essential fatty acids that our body can't make from other types of oils. It also provides detailed analysis of those oils to help you choose the one that is right for you. I hope that further research may find some essential nutrients in bacon, but for the summary of the current research results on fats in human nutrition I still come back to this book.
4 of 4 people found the following review helpful:
5.0 out of 5 stars
good nutrition,
By A Customer
This review is from: Essential Fatty Acids in Health & Disease : Using the Essential Fats w3 and w6 to Improve Your Health, Lower Your Cholesterol, and Prevent Cardiovascular Disease (Paperback)
I am a young mother who wants to eat well for her baby. This book explained the essence of eating polyunsaturated fats to grow a good brain. The scientific reasoning is solid, the explanations are easy to follow, and the book is easy to read because of its humorous approach. This should be required reading!
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