A brilliant treatise that brings us closer to a 'unified field theory' explaining the underlying causes and pathophysiology behind CFS, FMS, and many other poorly understood syndromes . . . and also closer to effective treatment! My thanks and appreciation to Professor Pall for his excellent and ground-breaking work. -- Jacob Teitelbaum, MD, author of From Fatigued to Fantastic and Pain Free 1-2-3; Medical Director of the Fibromyalgia and Fatigue Centers Inc
A stunning expose on what is surely a central thesis of chronic, unexplained and fatiguing illness; namely, that oxidative stress mechanisms hold the key to any holistic viewpoint. He writes as a truth-seeker and as a biological scientist with a well reasoned and well documented style. This book could easily mark the end of the beginning of a more complete understanding of this complex field which is a trillion dollar nightmare of human misery and bio-political inattention. -- Paul R. Cheney, MD, PhD
Dr. Pall has put together as insightful and detailed view of a significant form of inflammatory biochemistry, in a manner that makes important contributions toward science-based treatment. . . . One can only hope that doctors and others with the sacred duty of care for the body/mind/spirit of another human being will read this book carefully. -- Grace Ziem, MD, PhD
Has clearly demonstrated the weight of the molecular evidence regarding these targeted diseases: chemical hypersensitivities, fibromyalgia, chronic fatigue and post-traumatic stress, and that their causation and progression implicates redox imbalances, or in other words, electronic imbalances. His model is unique in explaining the overlapping nature of these diseases (comorbidity), and explaining why they were previously so difficult to understand, diagnose and effectively treat. Dr. Pall has integrated a massive amount of molecular/biochemical data (this feat is astonishing to me) in order to present a well crafted model, which should convince serious minded scientists and doctors that these conditions are strongly associated with reactive molecular fragments, oxidative species and that inflammation and immune abnormalities are the consequences. The options for therapy are intriguingly varied, generally with attractive safety profiles. The political/environmental implications of this work are vast, and must be embraced for the health of all of us across the globe -- Stephen A. Levine, PhD; president and CEO of Allergy Research Group; co- author of Antioxidant Adaptation: Its Role in Free Radical Pathology
From the Publisher
Discover the answer to the mysteries of these debilitating illnesses
Explaining "Unexplained Illnesses" provides long-sought explanations for the properties of chronic fatigue syndrome (CFS), multiple chemical sensitivity (MCS), fibromyalgia, and posttraumatic stress disorder. This groundbreaking book examines common symptoms and signs; short-term stressors such as infection, chemical exposure, physical trauma, and severe psychological stress; why people are often diagnosed as having more than one of these illnesses, and approaches for treating the cause of each disease, rather than the symptoms. The book presents a detailed and well-supported mechanism (the NO/ONOO- cycle) that provides consistent explanations for many of the puzzling elements of these diseases.
At least a dozen scientists have proposed that chronic fatigue syndrome, multiple chemical sensitivity, and fibromyalgia must share a common mechanism; others have suggested posttraumatic stress disorder may belong to this group as well. This unique book provides explanations for their previously unexplained properties with more than 1,500 references to scientific literature, creating a whole new approach to therapy and treatment of these illnesses.
Explaining "Unexplained Illnesses" provides answers to these questions:
How do short-term stressors initiate chronic illness?
How does the biochemistry of the NO/ONOO- cycle produce chronic illness?
How can the diverse symptoms and signs of these illnesses be generated as a Consequence of their common biochemistry?
Why is there so much variation in symptoms from one sufferer to another?
What are the principles underlying the NO/ONOO- cycle mechanism?
How does the NO/ONOO- cycle provide explanations for a dozen previously Unexplained properties of these illnesses?
How might 14 additional illnesses/diseases also be caused by the NO/ONOO- cycle etiology?
and many more!
Explaining "Unexplained Illnesses" is a must-read for physicians and scientists, and for anyone who suffers from-or knows someone who suffers from--these previously puzzling illnesses.