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Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome Paperback – April 25, 2007

ISBN-13: 978-0789023896 ISBN-10: 078902389X Edition: 1st

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Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome + Healing Severe Chemical and EMF Sensitivity: Our Breakthrough Cure for Multiple Chemical Sensitivities (MCS) and Electro-hypersensitivity (EHS) + Chemical Sensitivity
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Product Details

  • Paperback: 150 pages
  • Publisher: CRC Press; 1 edition (April 25, 2007)
  • Language: English
  • ISBN-10: 078902389X
  • ISBN-13: 978-0789023896
  • Product Dimensions: 1.2 x 5.8 x 8.2 inches
  • Shipping Weight: 1.5 pounds (View shipping rates and policies)
  • Average Customer Review: 4.3 out of 5 stars  See all reviews (24 customer reviews)
  • Amazon Best Sellers Rank: #635,771 in Books (See Top 100 in Books)

Editorial Reviews

Review

A brilliant treatise that brings us closer to a 'unified field theory' explaining the underlying causes and pathophysiology behind CFS, FMS, and many other poorly understood syndromes . . . and also closer to effective treatment! My thanks and appreciation to Professor Pall for his excellent and ground-breaking work. -- Jacob Teitelbaum, MD, author of From Fatigued to Fantastic and Pain Free 1-2-3; Medical Director of the Fibromyalgia and Fatigue Centers Inc

A stunning expose on what is surely a central thesis of chronic, unexplained and fatiguing illness; namely, that oxidative stress mechanisms hold the key to any holistic viewpoint. He writes as a truth-seeker and as a biological scientist with a well reasoned and well documented style. This book could easily mark the end of the beginning of a more complete understanding of this complex field which is a trillion dollar nightmare of human misery and bio-political inattention. -- Paul R. Cheney, MD, PhD

Dr. Pall has put together as insightful and detailed view of a significant form of inflammatory biochemistry, in a manner that makes important contributions toward science-based treatment. . . . One can only hope that doctors and others with the sacred duty of care for the body/mind/spirit of another human being will read this book carefully. -- Grace Ziem, MD, PhD

Has clearly demonstrated the weight of the molecular evidence regarding these targeted diseases: chemical hypersensitivities, fibromyalgia, chronic fatigue and post-traumatic stress, and that their causation and progression implicates redox imbalances, or in other words, electronic imbalances. His model is unique in explaining the overlapping nature of these diseases (comorbidity), and explaining why they were previously so difficult to understand, diagnose and effectively treat. Dr. Pall has integrated a massive amount of molecular/biochemical data (this feat is astonishing to me) in order to present a well crafted model, which should convince serious minded scientists and doctors that these conditions are strongly associated with reactive molecular fragments, oxidative species and that inflammation and immune abnormalities are the consequences. The options for therapy are intriguingly varied, generally with attractive safety profiles. The political/environmental implications of this work are vast, and must be embraced for the health of all of us across the globe -- Stephen A. Levine, PhD; president and CEO of Allergy Research Group; co- author of Antioxidant Adaptation: Its Role in Free Radical Pathology

From the Publisher

Discover the answer to the mysteries of these debilitating illnesses

Explaining "Unexplained Illnesses" provides long-sought explanations for the properties of chronic fatigue syndrome (CFS), multiple chemical sensitivity (MCS), fibromyalgia, and posttraumatic stress disorder. This groundbreaking book examines common symptoms and signs; short-term stressors such as infection, chemical exposure, physical trauma, and severe psychological stress; why people are often diagnosed as having more than one of these illnesses, and approaches for treating the cause of each disease, rather than the symptoms. The book presents a detailed and well-supported mechanism (the NO/ONOO- cycle) that provides consistent explanations for many of the puzzling elements of these diseases.

At least a dozen scientists have proposed that chronic fatigue syndrome, multiple chemical sensitivity, and fibromyalgia must share a common mechanism; others have suggested posttraumatic stress disorder may belong to this group as well. This unique book provides explanations for their previously unexplained properties with more than 1,500 references to scientific literature, creating a whole new approach to therapy and treatment of these illnesses.

Explaining "Unexplained Illnesses" provides answers to these questions:

How do short-term stressors initiate chronic illness?
How does the biochemistry of the NO/ONOO- cycle produce chronic illness?
How can the diverse symptoms and signs of these illnesses be generated as a Consequence of their common biochemistry?
Why is there so much variation in symptoms from one sufferer to another?
What are the principles underlying the NO/ONOO- cycle mechanism?
How does the NO/ONOO- cycle provide explanations for a dozen previously Unexplained properties of these illnesses?
How might 14 additional illnesses/diseases also be caused by the NO/ONOO- cycle etiology?
and many more!

Explaining "Unexplained Illnesses" is a must-read for physicians and scientists, and for anyone who suffers from-or knows someone who suffers from--these previously puzzling illnesses.


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Customer Reviews

For chronic fatigue sufferers this book is a must read.
Gilbert M.
There is a wealth of information in this book, much of it quite technical, but understandable for any informed and determined reader.
J. Steincamp
If you are new to this subject, this book is highly informative and well worth reading.
Buff Bethlen

Most Helpful Customer Reviews

46 of 48 people found the following review helpful By Southern Reader on September 6, 2007
Format: Paperback
In the groundbreaking new book "Explaining 'Unexplained Illnesses'", Dr. Martin Pall has proposed a new paradigm of human disease, the NO/ONOO- vicious cycle, which now explains CFS, MCS, FM, PTSD and GWS, bringing new hope for successful treatment and eventually a long hoped for cure. This paradigm also encompasses important illnesses such as asthma, autism, multiple sclerosis, Alzheimer's disease, Parkinson's disease and ALS, offering explanation and direction for research and treatment.

Dr. Pall clearly explains his new paradigm and the deranged biochemistry behind it. While the mechanism is complex, he gives hope to the millions who are suffering from these illnesses with an excellent chapter (Chapter 15) on treatment, mainly citing natural supplements as opposed to pharmaceuticals for disrupting this vicious cycle and returning the biochemistry to normal. He further explains the need for more research to develop the best treatment protocol and eventual cure.

Chapter 13, titled "What About Those Who Say It Is All in Your Head or That It All Starts in Your Head?", is a well-researched, heavily documented, pointed response to those who accuse these patients (of CFS and MCS particularly) of suffering from psychological/mental illness (or of being malingerers) rather than a physiological disease. As Dr. Pall points out, the chemical industry and insurance industry have vested interest in this issue, so as to avoid devastating liability lawsuits, payouts for disability, medical care and treatment.

As a former health care professional, I highly recommend this book as required reading for all people engaged in any aspect of the health care industry and all health care providers (from physicians to nurses to dentists) as well as for anyone who suffers from any of the illnesses impacted by this new disease paradigm. This book's importance cannot be overstressed.
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Format: Paperback
I hope you will make the time to read Dr. Pall's book and find it as inspirational and educational as I did. I was very excited to read about this NO/ONOO theory and explanation underlying these inflammatory illnesses: Multiple Chemical Sensitivity (MCS), Fibromyalgia (FM), Chronic Fatigue Syndrome (CFS), Gulf War Syndrome (GWS), Post Traumatic Stress Disorder (PTSD), etc. Take this book to your treating physician and discuss the protocols which fit your medical needs.
This book is dense with information - read the first chapter - The NO/ONOO Cycle and the Cause of Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia and Post-Traumatic Stress Disorder. If you find it too technical, skip to the section about your illness, then go back and see if the chemistry is easier to understand. But everyone should read this book - even if they don't understand the chemistry - just for the supportive information which validates their experience with their illness.
Referring to MCS, Dr. Pall writes," MCS initiation commonly involves chemical exposure, either a single high-level exposure or multiple lower-level exposures. The chemicals involved in initiation of MCS fall mainly into four classes, organophosphorus and carbamate pesticides and two other classes of pesticides, and volatile organic solvents." Page 4
The chapter on therapies is most helpful as it provides detailed information on agents expected to down-regulate the vicious NO/ONOO cycle. "At least 30 therapeutic agents or classes of agents are available today that are expected to down-regulate cycle biochemistry." Page 265 Dr. Pall lists the various protocols of Drs. Paul Cheney, Jacob Teitlebaum, Garth Nicolson, Nash Petrovic, and Grace Ziem.
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32 of 34 people found the following review helpful By Kimberly A. Russo on July 25, 2007
Format: Paperback
Dr. Martin Pall's book, Explaining "Unexplained Illnesses," proposes an insightful and carefully constructed theory for the cause of such mysterious illnesses as Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome. It is a must-read for those in the health care profession as well as any individual who has, or knows someone who has, the afore mentioned illnesses.

The theory is somewhat complicated as it proposes an entirely new paradigm for disease, yet Dr. Pall presents the material in such a way that even an undergraduate like myself can understand it. Each chapter includes an introduction to help ease the reader into the topic, as well as take-home lessons to summaries the material in a digestible way. For those interested in going into greater detail on any of the particular diseases, there is an entire chapter devoted to each one. The book provides concise summaries as well as unabridged, through explanation. Basically, there is something for every type of reader.
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21 of 22 people found the following review helpful By Buff Bethlen on September 21, 2007
Format: Paperback
Dr. Pall presents The NO/ONOO (pronounced, aptly, "No, oh no!) cycle as the causal mechanism for CFS FM MCS PTSD and related illnesses. Elevated levels of nitric oxide(NO)and its oxidant by-product, peroxynitrite (ONOO) propagate itself and create a chronic vicious cycle.

He says that focus should be on down-regulating the NO/ONOO cycle and presents many modalities collected from various researchers.

There is a wealth of information in this book and a valiant amount of attention to these illnesses, much of it quite technical, but quite understandable for any interested party.

If you have been dealing with and self-researching for ten, twenty years or more, you will find little that you didn't know or haven't tried. A number of sufferers say these modalities fall into 3 categories for them: 1) those that have caused negative effects 2) those that did nothing and 3) those that helped a little for a little while. Others have gotten real help for their condition.

If you are new to this subject, this book is highly informative and well worth reading.
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