Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation.
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1 of 1 people found the following review helpful:
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Fetal cells and fetal DNA - prenatal diagnosis,
By A Customer
This review is from: Fatal Cells and Fetal DNA in Maternal Blood: New Developments for a New Millenium : 11th Fetal Cell Workshop, Basel, April 15, 2000 (Hardcover)
This book covers the current state of the art concerning the use of fetal cells and fetal DNA in the blood of pregnant women for prenatal diagnosis. Each section is authored by a leading researcher in the field and covers subjects such as single cell PCR, automated cell recognition and the possible role of these molecules/cells in preeclampsia.
1 of 1 people found the following review helpful:
5.0 out of 5 stars
Fetal cells and fetal DNA - prenatal diagnosis,
By A Customer
This review is from: Fatal Cells and Fetal DNA in Maternal Blood: New Developments for a New Millenium : 11th Fetal Cell Workshop, Basel, April 15, 2000 (Hardcover)
This book covers the current state of the art concerning the use of fetal cells and fetal DNA in the blood of pregnant women for prenatal diagnosis. Each section is authored by a leading researcher in the field and covers subjects such as single cell PCR, automated cell recognition and the possible role of these molecules/cells in preeclampsia.
1 of 1 people found the following review helpful:
5.0 out of 5 stars
Non-invasive prenatal diagnosis:current state of the art,
By A Customer
This review is from: Fatal Cells and Fetal DNA in Maternal Blood: New Developments for a New Millenium : 11th Fetal Cell Workshop, Basel, April 15, 2000 (Hardcover)
This book covers the current state of the art of risk free prenatal diagnosis. It includes 18 contributions covering the use fo fetal cells, different enrichment procedures, automatic detection and the analysis of cell free fetal DNA. Their possible use in the detection of preeclampsia is also covered.
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