This volume documents the enormous progress that has been made in understanding the etiology, pathology, and genetics of fatal familial insomnia. Written by more than 50 leading international experts, including Elio Lugaresi, Christian Guilleminault, and other specialists who have long been at the forefront of sleep research, the book answers many long-held questions about this disease and sheds new light on one of the great biological mysteries of modern medicine. The in-depth coverage includes the latest findings on: the thalamus in sleep/wake regulation; the neurological syndromes associated with impairment of the thalamus; the complex interaction between thalamic and biological clock controlling mechanisms in sleep and wakefulness; and new information on the genetics of fatal familial insomnia and its relationship with the other entities grouped under the term "prion diseases".
