Freeze-Drying of Pharmaceuticals and Biopharmaceuticals: Principles and Practice [Hardcover]

Felix Franks (Author)

Book Description

ISBN-10: 0854042687 | ISBN-13: 978-0854042685 | Publication Date: April 4, 2007 | Edition: 1

This book describes the technology of freeze-drying with particular emphasis on the properties of the material to be processed, pre-freezing (formulation) and post-drying (stability and shelf life). It is the first single-author publication, centred mainly on the properties of the materials to be processed, stored and marketed. The book aims to take away the mystique which is still surrounding the technology and points the way to "Stability by Design".

Editorial Reviews

Book Description

Freeze-drying has recently been adopted by the pharmaceutical industry as a standard method for the production of stable solid preparations and this is the first book to specifically describe this process. The emphasis is on the properties of the materials processed, how effective formulations are arrived at, stored and marketed. In addition it looks at the processes and equipment involved, including: the physics, chemistry and biochemistry associated with freezing, aspects of formulation development, primary and secondary drying, the economics and engineering of scaling up and attributes of the dried product. An indispensable reference for the biopharmaceutical industry and academics.

--This text refers to an out of print or unavailable edition of this title.

From the Back Cover

Freeze-drying, in the past popular in the food industry, has more recently been adopted by the pharmaceutical industry as a standard method for the production of stable solid preparations. Freeze-drying of Pharmaceuticals and Biopharmaceuticals is the first book to specifically describe this process, as related to the pharmaceutical industry. The emphasis of this book is on the properties of the materials processed, how effective formulations are arrived at, and how they are stored and marketed. Beginning with a historical overview of the process, Freeze-drying of Pharmaceuticals and Biopharmaceuticals briefly describes the processes and equipment involved, including: the physics, chemistry and biochemistry associated with freezing, aspects of formulation development, primary and secondary drying; the economics and engineering of scaling up; and, most importantly, attributes of the dried product. It also discusses in detail the science behind freeze-drying, such as the properties of crystalline and amorphous solids. The book concludes with selected case studies and discusses the future of freeze-drying, advances in alternative drying methods, and concludes with an extensive bibliography. This book, written by a leading expert in the field, is aimed primarily at product and process developers in the biopharmaceutical industry and academia. Extract from a review: "...this book is a very useful and thorough overview of the processes in operation during freezing and lyophilization and should be read by all those who are interested in freeze drying and pharmaceutical formulation design. I certainly will be returning to it as an excellent summary of these important issues." CryoLetters, c/o Royal Veterinary College, London, UK

--This text refers to an out of print or unavailable edition of this title.

Product Details

• Hardcover: 136 pages
• Publisher: Royal Society of Chemistry; 1 edition (April 4, 2007)
• Language: English
• ISBN-10: 0854042687
• ISBN-13: 978-0854042685
• Product Dimensions: 9.2 x 6.2 x 0.7 inches
• Shipping Weight: 1 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #1,351,348 in Books (See Top 100 in Books)

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