Garrod's Inborn Factors in Disease: Including an annotated facsimile reprint of The Inborn Factors in Disease by Archibald E. Garrod (Oxford Monographs on Medical Genetics) [Facsimile] [Hardcover]

Charles R. Scriver (Editor), Barton Childs (Editor), Joshua Lederberg (Foreword)

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Book Description

Series: Oxford Monographs on Medical Genetics | Publication Date: June 8, 1989

Sir Archibald Garrod's first book, Inborn Errors of Metabolism (Oxford , 1908; reprint 1963), established chemical individuality as the paradigm of Mendelian variation. At the end of his career, Garrod wrote Inborn Factors in Disease (1931), in which he set out his belief that chemical individuality could result in individuals having a predisposition to certain diseases. It was not well received at the time, but now that many infectious diseases which have been the scourge of previous generations have been controlled, the relative importance of genetic disease has increased dramatically, while the establishment of recombinant DNA methods has made it possible to identify inherited defects and risks in the genes of individuals and families. How these individuals and their families can be helped is a major challenge for today's medicine and for society. Thus, it is timely to reprint Garrod's own words which anticipated that challenge so well. This facsimile reprint contains the entire original text, along with historical commentary and observations regarding Garrod's relevance today.

#outer_postBodyPS { display: none; } #psGradient { display: none; } #psPlaceHolder { display: none; } #psExpand { display: none; } Sir Archibald Garrod's first book, Inborn Errors of Metabolism (Oxford , 1908; reprint 1963), established chemical individuality as the paradigm of Mendelian variation. At the end of his career, Garrod wrote Inborn Factors in Disease (1931), in which he set out his belief that chemical individuality could result in individuals having a predisposition to certain diseases. It was not well received at the time, but now that many infectious diseases which have been the scourge of previous generations have been controlled, the relative importance of genetic disease has increased dramatically, while the establishment of recombinant DNA methods has made it possible to identify inherited defects and risks in the genes of individuals and families. How these individuals and their families can be helped is a major challenge for today's medicine and for society. Thus, it is timely to reprint Garrod's own words which anticipated that challenge so well. This facsimile reprint contains the entire original text, along with historical commentary and observations regarding Garrod's relevance today.

Product Details

Hardcover: 264 pages
Publisher: Oxford University Press, USA; Facsimile of 1931 ed edition (June 8, 1989)
Language: English
ISBN-10: 0192615742
ISBN-13: 978-0192615749
Product Dimensions: 9.5 x 6.4 x 0.8 inches
Shipping Weight: 1.3 pounds
Amazon Best Sellers Rank: #3,732,872 in Books (See Top 100 in Books)

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