Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.
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Book Description
This book takes the latest in genetic and molecular research and translates it into the clinical arena, explaining how gene expression and regulation impacts on disease processes. Written by experts in their field, this text demystifies genetics and molecular medicine and places it in the context of everyday diseases.
About the Author
Alan Wright is Programme Leader of the MRC Human Genetics Unit in Edinburgh.
Nicholas Hastie is Director of the MRC Human Genetics Unit in Edinburgh.
Nicholas Hastie is Director of the MRC Human Genetics Unit in Edinburgh.
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3.0 out of 5 stars
Not for a layperson,
This review is from: Genes and Common Diseases: Genetics in Modern Medicine (Paperback)
Unless you are in the medical field, this might not the book for you. I don't feel it is meant for the layperson. It is highly technical.
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Key Phrases - Statistically Improbable Phrases (SIPs):
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colorectal cancer susceptibility, mapping complex disease traits, gene discovery efforts, cataract genes, relative survival probability, admixture mapping, recent positive selection, susceptibility variants, causal variant, functional candidate genes, high bone mass, familial expansile osteolysis, malaria susceptibility, whole genome screens, pharmacogenetic testing, thalassemia alleles, chain imbalance, linkage signals, colorectal cancer risk, allelic heterogeneity, unfolded protein response, survival phenotypes, neonatal diabetes mellitus, pseudohypoaldosteronism type, exceptional longevity Key Phrases - Capitalized Phrases (CAPs): (learn more)
Hum Genet, Nat Genet, Proc Natl Acad Sci, Hum Mol Genet, Nature Genetics, Med Genet, Infect Dis, Biol Chem, Cell Biol, Clin Invest, World Health Organization, Oxford University Press, United States, Respir Crit Care Med, Nat Med, New York, Nat Rev Genet, Trends Genet, Archives of General Psychiatry, Arthritis Rheum, Mol Psychiatry, United Nations, Declaration of Helsinki, Human Molecular Genetics, New England Journal of Medicine New!
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colorectal cancer susceptibility, mapping complex disease traits, gene discovery efforts, cataract genes, relative survival probability, admixture mapping, recent positive selection, susceptibility variants, causal variant, functional candidate genes, high bone mass, familial expansile osteolysis, malaria susceptibility, whole genome screens, pharmacogenetic testing, thalassemia alleles, chain imbalance, linkage signals, colorectal cancer risk, allelic heterogeneity, unfolded protein response, survival phenotypes, neonatal diabetes mellitus, pseudohypoaldosteronism type, exceptional longevity Key Phrases - Capitalized Phrases (CAPs): (learn more)
Hum Genet, Nat Genet, Proc Natl Acad Sci, Hum Mol Genet, Nature Genetics, Med Genet, Infect Dis, Biol Chem, Cell Biol, Clin Invest, World Health Organization, Oxford University Press, United States, Respir Crit Care Med, Nat Med, New York, Nat Rev Genet, Trends Genet, Archives of General Psychiatry, Arthritis Rheum, Mol Psychiatry, United Nations, Declaration of Helsinki, Human Molecular Genetics, New England Journal of Medicine New!
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Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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