The high mutation frequencies, population heterogeneity and rapid evolution potential of RNA viruses make them a prime object for investigation by virologists, immunologists and molecular biologists. This high level of interest is evident in this volume, which contains 14 concise and timely reviews of various areas of RNA virology. Standard RNA viruses (riboviruses) and retroviruses are reviewed, and facts and principles of their diversity and evolution are discussed. RNA virus mutation, population structure and rapid evolution (or paradoxical stasis) are examined in detail for a number of different RNA viruses. The problems created by the unusual genetics of RNA viruses are discussed: AIDS pathogenesis, antigenic change and vaccine problems, resistance to antiviraldrugs and origins of influenza outbreaks.
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