196 of 206 people found the following review helpful:
4.0 out of 5 stars
Uneven, February 28, 2000
I'm not sure whether to give this book four or five stars...
FIVE STARS - because of how interesting the subject matter is. DNA, it seems, isn't a brilliant piece of software to make bodies. It's more a committee of chemicals each trying to propogate themselves, and often at odds with the other chemicals in DNA (97% of which don't actually do anything!) And this is the stuff that to a large extent makes us US!
FIVE STARS - because of how well written some sections are. Chapter 4, for instance, which talks about the researcher who not only can tell you IF you're going to get Huntington's chorea, but can tell you what age you'll get it, simply by counting the number of times a particular gene sequence repeats. I was left haunted by the question, if I had a high risk for H.C., would I get the test done, simply to know when the symptoms would start?
FIVE STARS - Because of the research. This is the most up to date book on the subject available at the moment. He cites research done as close as 1998.
BUT FOUR STARS - because although some parts were absolutely mind-blowingly interesting and could be considered _classic_ bits of writing, the prose in other parts seemed to get a bit heavy and tedious, and I had to put it down. I was surprised by my own reaction, having been so thoroughly entertained a few short chapters before. But it means I can't give it five stars, because that rating is for out and out classics. (Which this book nearly is. Damn.)
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83 of 87 people found the following review helpful:
5.0 out of 5 stars
Tremendously entertaining, enjoyable romp through genetics, June 6, 2003
This is the book that I wish Steven Pinker's "How the Mind Works" was. Matt Ridley unfolds the human genome for us in a crisply written and precise "Autobiography of a Species in 23 Chapters." OK, I don't know what the Hades that means, but this guy is a good writer, a smart scientist, and a friendly teacher of what is a really cool, but intimidating, branch of learning.
Ridley's got a little shtick, which he openly mocks himself, where his 23 chapters each represent one of the 23 human chromosomes. It's kind of an interesting little angle, you want to like this guy, anyway, so the shtick mostly works, although I don't really have a sense that each of our 23 chromosomes is a particular type of chromosome at the end of it.
Genome is a lot of good science explained with a clear, well-constructed hand. In an excellent seven-page introduction, Ridley answered for me all sorts of questions that my scientifically-literate yet communication-challenged science friends have been unable to answer, to wit:
"Imagine that the genome is a book.
There are twenty-three chapters, called Chromosomes.
Each chapter contains several thousand stories, called Genes.
Each story is made up of paragraphs, called Exons, which are interrupted by advertisements called Introns.
Each paragraph is made up of words, called Codons.
Each word is written in letters called Bases."
Very nicely done, brings it to an understandable level for the literate layperson, and establishes a very solid foundation from which he is able to unfold the rest of this story.
He handles the basic science very well, and mostly shys away from the "Believe It or Not!" school of science reporting, though the occasional oddity does pop up. One thing I found fascinating is the existence of "chimeras." Which is one creature ( a human, a mouse, anything) that has two different genomes in it: "Think of them as the opposite of identical twins: two different genomes in one body, instead of two different bodies with the same genome." This means that you could be the single body of two different people that had accidentally fused in the womb. Really weird thought experiment, no?
He places humans and our development in the context of our nearest genetic cousins - the chimpanzees and the gorillas and so forth. And elucidates a number of compare and contrast thoughts: "What it means is that the mating system of the species was changing. The promiscuity of the chimp, with its short sexual liaisons, and the harem polygamy of the gorilla, were being replaced with something much more monogamous: a declining ratio of sexual dimorphism is unambiguous evidence for that."
Ridley's wordcraft is superior. Enjoy all the learning, implications, and human foibles he packs into this one sentence on language acquisition:
"Thus, although no other primate can learn grammatical language at all - and we are indebted to many diligent, sometimes gullible and certainly wishful trainers of chimpanzees and gorillas for thoroughly exhausting all possibilities to the contrary - language is intimately connected with sound production and processing."
It is really just masterful. Even more enjoyable if you read it in an English accent on account of Ridley's living there according to the dust jacket.
In sum, if you are looking for an introduction to genetics, DNA, and our genome, and are the omnivore type of reader with a decent head on your shoulders, this book is for you. I enjoyed it tremendously and it's given me a very good grounding for my further reading into evolutionary psychology.
Enjoy strongly!
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79 of 86 people found the following review helpful:
5.0 out of 5 stars
Things Have Changed, February 21, 2000
Things have, indeed, changed. This book chronicles the opening of the Genome mystery and the path science has taken to reach today's level of knowledge. It also includes a far reaching discussion of the current discoveries of DNA and the impact (including a realistic cure for Cancer) that they will have on our lives in the future.
This is a far ranging discussion, moving from the genetic impacts on sexuality, personality, disease (or more appropriately resistance to disease), longevity, and other topics. It is an excellent, intriguing book for anyone who reads it. The scientific information can get a little overwhelming, but every turn of the page can reveal a new understanding about who we are and how our exploding genetic knowledge might shape our future.
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