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The Genome War: How Craig Venter Tried to Capture the Code of Life and Save the World
 
 
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The Genome War: How Craig Venter Tried to Capture the Code of Life and Save the World [Abridged, Audiobook] [Audio CD]

James Shreeve (Author), Erik Singer (Reader)
5.0 out of 5 stars  See all reviews (17 customer reviews)


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Book Description

0739309943 978-0739309940 January 6, 2004 Abridged
The long-awaited story of the science, the business, the politics, the intrigue behind the scenes of the most ferocious competition in the history of modern science—the race to map the human genome.
On May 10, 1998, biologist Craig Venter, director of the Institute for Genomic Research, announced that he was forming a private company that within three years would unravel the complete genetic code of human life—seven years before the projected finish of the U.S. government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work.
At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society.

The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry.


From the Hardcover edition.


Editorial Reviews

From Publishers Weekly

Serendipity, not to mention pure entrepreneurial tenacity, played a huge role in the quest to unravel the complete human DNA code, which is detailed in this fascinating narrative from Shreeve (The Neanderthal Enigma). Brash and bold biologist Craig Venter, the central player in this drama, is a polarizing figure, one who finds his new company Celera (Latin for "speed") going head-to-head with the National Institutes of Health. The stakes: bragging rights for a discovery that will have long-reaching applications to human health and longevity and a body of data that could be immensely profitable-that is, if Venter can figure out how to make money from the genome code without defying his promise to make the information freely available to the public. Singer has a pleasant voice, firm and authoritative. Books like this seldom need character voices, but Singer uses different inflections and tones for each of the many principal players, which adds a touch of drama and color to the tale. The story can be elliptical and repetitive-after a while, one conference call or heated exchange begins to sound like another-and is almost twice as long as it needs to be. Science aficionados, however, will savor every detail.
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From The New England Journal of Medicine

On Charles Darwin's birthday -- February 12 -- in 2001, two groups of scientists announced simultaneously that the human genome sequence had been completed. The public consortium, involving teams from six countries, published its results in Nature and made them immediately available on the Internet. Craig Venter's company, Celera Genomics, published its paper in Science. Those announcements, although premature (only two rough drafts were available, accompanied by some preliminary analyses), marked one of the few uncontroversial moments in the quest for the human genome sequence. Almost everything else, from the ownership of the results to the molecular and statistical methods used, was the subject of sharp conflict. The title of this book, The Genome War, is only partly exaggerated. No casualties were reported, but all the psychological ingredients of a war were present and are documented in the book. The subtitle is a joke, I hope. The Genome War has something in common with Les Liaisons Dangereuses. In Laclos's novel, the apparent goal of the characters -- to seduce a human being -- is little more than a pretext for a cruel game of power. Two centuries later the pretext has become grander -- the goal no longer centers on a single person, but on the DNA of the species -- but the game is no less cruel. Through 26 dense chapters, Shreeve displays for us the intricate game of personalities and ambitions that ultimately led to the completion of the Human Genome Project. Great stories need great characters. Shreeve chose Craig Venter, and in this choice lies the appeal of the book as well as its main limitation. Venter, or at least the Venter whom Shreeve describes, is the herald of glamour, efficiency, and free enterprise. He enters the book onboard his yacht, and from that moment on, any scientist with "home-cut hair" who wears "whatever old sweater and slacks first presented themselves to him on waking up" has a hard time. Big projects, big money, big rewards for the investors; everything related to Venter is formidable, never mind that certain pages of the book are too much reminiscent, for my taste, of Lifestyles of the Rich and Famous. On the other hand, to offer a suitable stage for such a character, Shreeve continuously has to create dramatic situations. Often he does so by reporting private conversations and very personal thoughts, which in many cases he cannot have learned from the horse's mouth. As a result, the readers simply do not understand what cocktail of fiction and nonfiction they actually have in their hands. More important, crucial aspects of the story and other key figures -- notably John Sulston, the head of genome sequencing at Britain's Sanger Institute -- are left in the shadows. I doubt that the average reader will realize how important it has been to ensure that the human DNA sequence remains freely available to all (despite and against Venter's wishes). Far too few words are spent to explain that Celera could put together its results only by using the data produced and made available to all by the public consortium. In brief, this is not the most balanced or rigorous book on the Human Genome Project. However, some of its pages are worth reading. I liked this image of the Cold Spring Harbor Laboratory: "In the hallways and stairwells hang photographs of the original apostles of the new science: Delbruck himself, Salvador Luria, Crick and Watson, Barbara McClintock, Jacques Monod, Alfred Hershey . . . forever young and cocksure, their eyes bright from the birth of ideas that will take their older, grayer selves to Stockholm." Guido Barbujani
Copyright © 2004 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS. --This text refers to the Hardcover edition.

Product Details

  • Audio CD
  • Publisher: Random House Audio; Abridged edition (January 6, 2004)
  • Language: English
  • ISBN-10: 0739309943
  • ISBN-13: 978-0739309940
  • Product Dimensions: 5.7 x 4.9 x 1 inches
  • Shipping Weight: 7.8 ounces
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (17 customer reviews)
  • Amazon Best Sellers Rank: #3,366,309 in Books (See Top 100 in Books)

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62 of 63 people found the following review helpful:
5.0 out of 5 stars And now for the other side, January 30, 2004
By 
Several books have already covered many aspects of the race to sequence the human genome. These books were either written by outsiders with limitted access or in the case of The Common Thread by an insider from the public human genome project. For the first time this book gives the perspective of someone who had intimate access to the people, premises and meetings at Celera Genomics. As an insider at Celera I can vouch for the accuracy of the events covered in the book that I was present for as well as the spirit of the endeavor captured by this book. While I am undoubtedly biased, I found the quality of the narative for this book to be better than that of its rivals and the content more compelling. Shreeve also covers the concurrent public effort and does a nice job of explaining many of the technical challenges in an understandable fashion, but what is unique to this book is the story from behind the scenes at Celera as well as some in depth descriptions of the people involved. If you are at all interested in the whole story about this moment in history you need to read this book!
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22 of 23 people found the following review helpful:
5.0 out of 5 stars A complex story well told, May 31, 2004
By 
Bosco Ho (San Francisco, USA) - See all my reviews
(REAL NAME)   
This is a ferciously well-written account of the race to map the human genome, one of the most sordid and expensive races in the history of science. Virtually alone amongst the books available out there on the genome race, this book tells the story from the point of view of Craig Venter. Not only that, but James Shreeve had a complete fly-on-the-wall view of the inner workings of Celera, allowing Shreeve to give a full-blooded account of the implosion of Venter's dream, that of becoming the Bill Gates of Biotech.

Shreeve has done the impossible by pulling the threads of this immense story into a tight coherent narrative. At the end of the story, we understand how Venter ended up in the embarassing situation of negociating a so-called "tie" in the race for the human genome. Shreeve has a novelistic eye for detail in painting memorable portraits of the many people involved in the story. The science is vividly introduced when needed, but the complex financial and political moves are also explicated with authority. This is very very good writing.

Although Craig Venter has often been demonized amongst scientific circles, it was always an open question whether Venter was the devil incarnate, or an incredibly naive scientist who made one stupid faustian bargain after another. While there is no doubt that Venter is a brilliant man, Shreeve' account portrays Venter as a financial masochist, a victim of financial forces beyond his understanding.

In the preface, Shreeve explained that he had originally wanted a balanced account of the race as he tried to get access to the head of the public Human Genome Project, Francis Collins. He was refused. Because of that, Shreeve has structured the book as a character study of Venter, where we are privy to all his inner trials and tribulations. From being embedded in the private side of the race, Shreeve introduces a subtle bias in the account. The private researchers at Celera are fun and daring, even glamorous, whereas the public scientists are inefficient, stodgy, yawningly boring white-lab coats, especially when they talk about the ethical stuff. In my experience, it's been the opposite. I know researchers who have come back into academia because industry research was so achingly boring.

One big gripe I have with this book is that Shreeve glides over why the public project was so fixated on trying to keep the map open, free and accessible. Shreeve makes the leaders of the public project sound like shrill ideologues, constantly harping on over some kind of utopian ideal. This subtle bias ignores the heavily documented, though much ignored, literature over the pathological behaviour of the pharmaceutical industry. A commercial monopoly over the human genome would have been a disaster for public health (as opposed to rich men's health), and Celera came close to destroying the fragile consensus in academia science.

Apart from this gripe, I do recommend that you read this book if you want a sophisticated guide to one of the most fascinating collisions between commerical and public science, as well as a superb study of scientific ambition.

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12 of 12 people found the following review helpful:
5.0 out of 5 stars Pure joy! A science writing masterpiece., March 1, 2004
By 
R. Thompson (Geneva, Switzerland) - See all my reviews
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If you read only one science book this year, it has to be James Shreeve's inside view of the race to sequence the human genome. The story of this tumultuous competition between the prestigious Human Genome Project and the brash visionary Craig Venter is a joy ride. Shreeve's irreverent, charming and ultimately thrilling tale is a masterpiece of science writing. The white coats (and white hats) drop away in this book as Shreeve reveals the majesty of science for what it has always been, a very human story. Bravo!
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First Sentence:
On the morning of June 26, 2000, a short, elderly man walked up the pedestrian lane along the east side of the White House grounds and joined a couple of dozen people already gathered outside the guest entrance, under the shade of the willow oak trees that line the lane. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
genome war, flu genome, capillary machine, annotation jamboree, salmonella virus, shotgun assembly, genome race, shotgun technique, human code, genome program, fruit fly genome, assembly algorithm, shotgun method, gene patents, assembly team, sequencing machines, genome centers, mate pairs, conversation with the author, sequencing operation, biotech sector, genome project, public program
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Human Genome Project, Francis Collins, Perkin Elmer, Tony White, Craig Venter, Hamilton Smith, Mark Adams, Gene Myers, Wellcome Trust, Cold Spring Harbor, Paul Gilman, Eric Lander, Peter Barrett, White House, Sanger Centre, Michael Hunkapiller, Robert Millman, United States, Nobel Prize, Whitehead Institute, Gerry Rubin, Sam Broder, Washington University, James Watson, Wall Street
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