Greene's Protective Groups in Organic Synthesis [Hardcover]

Peter G. M. Wuts (Author), Theodora W. Greene (Author)

Book Description

ISBN-10: 0471697540 | ISBN-13: 978-0471697541 | Publication Date: October 30, 2006 | Edition: 4

The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including...

• New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines
• New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique
• Expanded coverage of the unexpected side reactions that occur with protective groups
• New chart covering the selective deprotection of silyl ethers
• 3,100 new references from the professional literature

The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.

Editorial Reviews

Review

"An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007)

"...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007)

"...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)

From the Back Cover

The Most Comprehensive Guide to Protective Groups in Organic Synthesis Currently Available

For more than twenty-five years, Protective Groups in Organic Synthesis has been the definitive guide for organic chemists in designing synthetic routes. Now in its fourth edition, the text continues to be a uniquely comprehensive and an indispensable reference for both synthetic organic and medicinal chemists who want to control the reactivity of the most common functional groups during a synthetic sequence.

The Fourth Edition includes significant developments in protective group chemistry since 1998. In addition to incorporating new protective groups now available to the synthetic organic chemist, such as the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines, the book also covers new techniques for the formation and cleavage of existing protective groups, providing the most relevant and useful examples to illustrate each methodology. The content is organized around the functional group to be protected (ethers, acids, carbonyl groups, amines, amides, phenols, etc.), and ranges from the simplest to the most complex highly specialized protective groups.

New features of the Fourth Edition include:

• The addition of numerous new protective groups, such as the fluorous family
• New methods for the cleavage and introduction of many of the classic protective groups highlighting selectivity issues when reported in the literature
• Expanded coverage of the unexpected side reactions that occur with protective groups
• A new chart covering the selective deprotection of silyl ethers
• 3,100 new references from the professional literature, complete through the end of 2005

See all Editorial Reviews

Product Details

• Hardcover: 1110 pages
• Publisher: Wiley-Interscience; 4 edition (October 30, 2006)
• Language: English
• ISBN-10: 0471697540
• ISBN-13: 978-0471697541
• Product Dimensions: 9.4 x 6.4 x 2.2 inches
• Shipping Weight: 3.4 pounds (View shipping rates and policies)
• Average Customer Review: 4.8 out of 5 stars  See all reviews (14 customer reviews)
• Amazon Best Sellers Rank: #200,647 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

6 of 6 people found the following review helpful:

5.0 out of 5 stars Quintessential Book for Organic Chemists, July 17, 2000

By 

Ray Frazier - See all my reviews

This review is from: Protective Groups in Organic Synthesis (Hardcover)

This book is absolutely essential for the organic chemist. Well organized by functional group to be protected and well indexed to allow searches by protection group, this book has it all. If you have a question about how to protect a particular functional group, this is the book for it. Under each section a plethora of references may be found--with each one succinctly summarized to avoid looking for references that have nothing to do with what you want. This book is essential whether you are a graduate student studying what reactions you need to know to do the research assigned you or a professor writing research proposals (indeed, I bought my own copy of this book from Amazon because the ones in our school library were always checked out to one of the professors). In summary, it is an excellent reference text that should be on every organic chemist's desk.

4 of 4 people found the following review helpful:

5.0 out of 5 stars Essential, August 14, 2001

By 

AML - See all my reviews

This review is from: Protective Groups in Organic Synthesis (Hardcover)

If you are a graduate student in organic chemistry then this book is a must. It will help with class work as well as your lab work. This book is the authority on protective groups and is an essential reference.

2 of 2 people found the following review helpful:

5.0 out of 5 stars essential reference, November 10, 1999

By 

J. Evans (Worcester, MA United States) - See all my reviews
(REAL NAME)   

This review is from: Protective Groups in Organic Synthesis (Hardcover)

Like every other edition of Greene's Protective Groups, this updated version is concise with reliable references and schematics. All researchers need this book.