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Greene's Protective Groups in Organic Synthesis [Hardcover]

Peter G. M. Wuts , Theodora W. Greene
4.8 out of 5 stars  See all reviews (18 customer reviews)

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Greene's Protective Groups in Organic Synthesis Greene's Protective Groups in Organic Synthesis
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Book Description

October 30, 2006 0471697540 978-0471697541 4
The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including...
  • New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines
  • New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique
  • Expanded coverage of the unexpected side reactions that occur with protective groups
  • New chart covering the selective deprotection of silyl ethers
  • 3,100 new references from the professional literature
The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.

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Greene's Protective Groups in Organic Synthesis + Strategic Applications of Named Reactions in Organic Synthesis + Modern Physical Organic Chemistry
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Editorial Reviews

Review

"An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007)

"...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007)

"...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)

From the Back Cover

The Most Comprehensive Guide to Protective Groups in Organic Synthesis Currently Available

For more than twenty-five years, Protective Groups in Organic Synthesis has been the definitive guide for organic chemists in designing synthetic routes. Now in its fourth edition, the text continues to be a uniquely comprehensive and an indispensable reference for both synthetic organic and medicinal chemists who want to control the reactivity of the most common functional groups during a synthetic sequence.

The Fourth Edition includes significant developments in protective group chemistry since 1998. In addition to incorporating new protective groups now available to the synthetic organic chemist, such as the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines, the book also covers new techniques for the formation and cleavage of existing protective groups, providing the most relevant and useful examples to illustrate each methodology. The content is organized around the functional group to be protected (ethers, acids, carbonyl groups, amines, amides, phenols, etc.), and ranges from the simplest to the most complex highly specialized protective groups.

New features of the Fourth Edition include:

  • The addition of numerous new protective groups, such as the fluorous family
  • New methods for the cleavage and introduction of many of the classic protective groups highlighting selectivity issues when reported in the literature
  • Expanded coverage of the unexpected side reactions that occur with protective groups
  • A new chart covering the selective deprotection of silyl ethers
  • 3,100 new references from the professional literature, complete through the end of 2005

Product Details

  • Hardcover: 1110 pages
  • Publisher: Wiley-Interscience; 4 edition (October 30, 2006)
  • Language: English
  • ISBN-10: 0471697540
  • ISBN-13: 978-0471697541
  • Product Dimensions: 2.1 x 6.3 x 9.2 inches
  • Shipping Weight: 3.4 pounds (View shipping rates and policies)
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (18 customer reviews)
  • Amazon Best Sellers Rank: #431,677 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews
7 of 7 people found the following review helpful
5.0 out of 5 stars Quintessential Book for Organic Chemists July 17, 2000
Format:Hardcover
This book is absolutely essential for the organic chemist. Well organized by functional group to be protected and well indexed to allow searches by protection group, this book has it all. If you have a question about how to protect a particular functional group, this is the book for it. Under each section a plethora of references may be found--with each one succinctly summarized to avoid looking for references that have nothing to do with what you want. This book is essential whether you are a graduate student studying what reactions you need to know to do the research assigned you or a professor writing research proposals (indeed, I bought my own copy of this book from Amazon because the ones in our school library were always checked out to one of the professors). In summary, it is an excellent reference text that should be on every organic chemist's desk.
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5 of 5 people found the following review helpful
5.0 out of 5 stars Essential August 14, 2001
By AML
Format:Hardcover
If you are a graduate student in organic chemistry then this book is a must. It will help with class work as well as your lab work. This book is the authority on protective groups and is an essential reference.
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2 of 2 people found the following review helpful
5.0 out of 5 stars essential reference November 10, 1999
Format:Hardcover
Like every other edition of Greene's Protective Groups, this updated version is concise with reliable references and schematics. All researchers need this book.
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1 of 1 people found the following review helpful
5.0 out of 5 stars Protecting my thesis August 15, 2004
Format:Hardcover
This book contains methods for the installation and removal of practically every protecting group you can think of, and likely some you've never encountered. Most methods are referenced to articles containing representative procedures, saving valuable time scouring the literature. It is compact, well-organized and reasonably priced. Along with March's Advanced Organic Chemistry, this book is a must have for any organic chemist.
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1 of 1 people found the following review helpful
5.0 out of 5 stars Indispensible August 13, 1999
By A Customer
Format:Hardcover
Quite possibly the most important protecting group book published. The new edition is out and is even more extensive and completely up to date. However, "Greene and Wuts" is a bible in the laboratory. Many of you who will read this have probably scrambled for your copy of "Greene," as it is affectionately known, when designing a synthesis. Also check out Kocienski's protecting group book and his extensive reviews if you do not know about them.
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1 of 1 people found the following review helpful
5.0 out of 5 stars A must for any organic chemist February 9, 1998
By A Customer
Format:Hardcover
The most comprehensive text on protecting groups there is. Much better than "Protecting Groups" by Phillip J. Kocienski
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2 of 3 people found the following review helpful
5.0 out of 5 stars A must have for any synthetic laboratory April 26, 2006
Format:Hardcover|Verified Purchase
There are other protecting group books out there but I found this one to be the most comprehensive and easy to use.
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5.0 out of 5 stars Excellent library piece January 26, 2014
Format:Hardcover|Verified Purchase
Book was in better condition than I expected. The book lists out basic protection and deprotection chemistry for alcohols, carbonyls, carboxyls, thiols, and amines. Great reference with lots of procedures.
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Most Recent Customer Reviews
5.0 out of 5 stars Must-Have Reference
As a trained carbohydrate chemist, I deal with protecting groups on a daily basis, and "Greene's" is always on my desk. Read more
Published 6 months ago by Matt
5.0 out of 5 stars Must-Have
I think this book should be required in every chemistry laboratory. Very thorough! The charts in the back of the book are especially helpful.
Published 11 months ago by Alfio Fichera
5.0 out of 5 stars very useful
it helps a lot in total synthesis and all other chemical applications related to specific synthesis and modifications of molecules
Published 12 months ago by A. Anatoly
5.0 out of 5 stars good handbook
Peter's book is an excellent and essential handbook for all organic chemists. Everyone should have one in hand.
Published on July 24, 2010 by M. H. Chen
4.0 out of 5 stars Chemists that make stuff.
If you're a synthetic chemist, you know you need this book.
It's well organised by functional group, though I could quibble with details as to orthogonal stability. Read more
Published on February 1, 2010 by AG Jones
4.0 out of 5 stars Greene's Protective Groups in Organic Synthesis (Purchased on...
Greene's Protective Groups in Organic Synthesis (Purchased on 10/02/2008)
by Peter G. M. Wuts
Published on November 3, 2008 by valerio
4.0 out of 5 stars glad i bought it
i'm do organic synthesis. i reference this one once a week on average. it's the first stop whenever a protecting group questions comes up.
Published on August 30, 2007 by art vandelay
5.0 out of 5 stars must have
if you are synthetic chemist you ought to have this book with you
Published on February 23, 2006 by Abhirup Das
5.0 out of 5 stars The Book Will be Your Bible in Lab
If you doing any sort of organic chemistry in the lab, you will really get your hands into this handy reference on protecting groups. Read more
Published on February 4, 2002 by Matthew M. Yau
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