Progress in Clinical and Biological Research, Volume 391 Growth Factors and Tumor Promotion Implications for Risk Assessment R. Michael McClain, Thomas J. Slaga, Robert LeBoeuf, and Henry Pitot, Editors Understanding the biological, cellular, and molecular mechanisms of growth factors in carcinogenesis is essential to predicting tumor development both in research and clinical settings. An up-to-date and much needed overview of this field, Growth Factors and Tumor Promotion: Implications for Risk Assessment presents cutting-edge work from scientists involved in all areas of oncology and cancer biology. The book presents 32 chapters exploring a wide range of specialized topics in this field. Material in the text ranges from the biological changes caused by growth factors to quantifying cancer risk based on the biological data and the carcinogen bioassay. Extensive coverage is given to the complex mechanisms of growth factors in the process of tumor progression, in addition to numerous studies involving both animal models and analogous clinical cases. Growth Factors and Tumor Promotion addresses such specific topics as:
- a decision tree approach for carcinogenesis risk assessment
- hypomethlyation of DNA: a possible epigenetic mechanism involved in tumor promotion
- transforming growth factor-ßs in mammary tumorigenesis
- genetic factors controlling skin tumor promotion in mice
- benzoyl peroxide: review of experimental carcinogenesis and human safety data
- mechanistic considerations in risk assessment for epigenetic tumor-promoting carcinogens
