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The Handbook of Clinically Tested Herbal Remedies 2 Volume set [Hardcover]

Marilyn Barrett (Author)
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Book Description

May 2004 0789010682 978-0789010681 1
A single source for accurate scientific information on herbal remedies!

This comprehensive handbook (comprised of two volumes of 700+ pages each) provides a snapshot of 160 herbal products that have been tested in clinical trials. Details of the products and the clinical trials they underwent are here in an easy-to-read, at-a-glance format.

Each botanical profile in The Handbook of Clinically Tested Herbal Remedies contains a summary section (table, text and references), followed by product information and clinical trials for that particular product. An evaluation of the strength of the evidence from the trials, along with the context for therapeutics is included to give you a complete picture of each remedy and its usefulness or lack thereof. If there is more than one product based on a particular botanical then the trials are grouped according to the product.

This valuable book also makes purchasing easy with manufacturer contact information. With over 30 individual botanicals and 10 multi-ingredient formulas, 160 products and 360 clinical studies, The Handbook of Clinically Tested Herbal Remedies is the book you need to make an informed selection of herbal products. Not only does it list proprietary herbal products that have been tested in controlled clinical studies and provide a rating of the quality of those trials, but, it also describes the fundamentals of herbal medicine, including regulation, characterization, standardization, bioavailability, efficacy, safety, pharmacopoeial monographs as well as incentives, or lack of incentive, for US and European manufacturers to conduct clinical studies.

Contributors to the chapters describing the fundamentals of herbal medicine include:

* the late Dr. Varro Tyler, Distinguished Professor Emeritus at Purdue University and co-author of Tyler's Honest Herbal, Rational Phytotherapy, and Tyler's Herbs of Choice
* Loren Israelsen, JD, president of the LDI group
* Tieraona Low Dog, MD, Chair of the USP Dietary Supplement Information Committee
* Joerg Grünwald, PhD, co-author of the Physicians Desk Reference (PDR) for Herbal Medicines, and Stefan Spiess, RPh, President of Grünwalder GmbH
* Anton Biber, PhD, and Friedrich Lang, PhD, experts in the bioavailability of herbal medicine at Dr. Willmar Schwabe GmbH & Co., Germany
* Anthony Almada, MSc, founder and Chief Scientific Officer of IMAGINutrition, Inc.
* Joseph M. Betz, PhD, Director of the Dietary Supplements Methods and Reference Materials Program at the NIH Office of Dietary Supplements
* Ezra Bejar, PhD, president of Plant Bioassay
* Uwe Koetter, PhD, Director of New OTC and Dietary Supplement Product Development at GlaxoSmithKline
* Srini Srinivasan, PhD, Vice President of the Dietary Supplement Verification Program of the United States Pharmacopeia (USP)
* Roy Upton, Executive Director of the American Herbal Pharmacopoeia.

All of the clinical trials in The Handbook of Clinically Tested Herbal Remedies were rated as to their Level of Evidence according to a system designed by Tieraona Low Dog, MD, Chair of the United States Pharmacopoeia Dietary Supplements/Botanicals Expert Panel and a member of the White House Commission on Complementary and Alternative Medicine. The reviewers of the clinical trials included Karriem Ali, MD; Richard Aranda, MD; Elliot Fagelman, MD; Mary Hardy, MD; David Heber, MD, PhD, FACP, FACN; John Trimmer Hicks, MD, FACP, FACR; Hannah Kim, MD; Franklin C. Lowe, MD, MPH; Richard D. O'Connor, MD; Barry S. Oken, M.D; Lynn Shinto, ND; and Keith Wesnes, PhD.


Editorial Reviews

Review

Clinicians searching for detailed and accurate information on herbal clinical trials will find much that is useful. -- Michael Rotblat, MD, PharmD, Associate Clinical Professor of Medicine, UCLA; Co-author of Evidence-Based Herbal Medicine

I wholeheartedly recommend this reference text... Thorough, informative, in-depth, and up-to-date. -- E. Ernst, MD, PhD, FRCP, FRCPEd, Director and Professor, Complementary Medicine, Peninsula Medical School, Universities of Exeter & Plymouth, United Kingdom

Product Details

  • Hardcover: 1508 pages
  • Publisher: Routledge; 1 edition (May 2004)
  • Language: English
  • ISBN-10: 0789010682
  • ISBN-13: 978-0789010681
  • Product Dimensions: 8.7 x 6.3 x 4.1 inches
  • Shipping Weight: 5.7 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Best Sellers Rank: #2,201,093 in Books (See Top 100 in Books)

 

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5.0 out of 5 stars Fantastic, Detailed Facts Based On Medical Studies, January 22, 2011
This review is from: The Handbook of Clinically Tested Herbal Remedies 2 Volume set (Hardcover)
"First Few Pages of the Books Contents"

PART I: FUNDAMENTALS OF HERBAL MEDICINE

Chapter 1. History and Regulation of Botanicals

in the United States 3

Loren D. Israelsen

Marilyn Barrett

Introduction 3

History 3

DSHEA Explained 5

Drugs: OTC and Rx 10

Prospectus 11

Chapter 2. Product Definition Deficiencies in Clinical

Studies of Herbal Medicines 13

Varro E. Tyler

Chapter 3. Identifying and Characterizing Botanical

Products 23

Marilyn Barrett

Identifying Plants by Name 24

Means of Assuring Plant Identity 26

Preparations and Formulations 30

Dose 30

Bioavailability 30

Guidelines 31

Appendix: Preparations and Formulations 32

Chapter 4. Standardization of Botanical Preparations:

What It Does and Does Not Tell Us 37

Uwe Koetter

Marilyn Barrett

Introduction 37

Standardization of Therapeutic Activity 38

Standardization to Meet a Chemical Norm 39

Standardization As a Reflection of Quality

Assurance Programs 41

Guidance 43

Situation in the Marketplace 44

Perspective 45

Chapter 5. The Importance and Difficulty in Determining

the Bioavailability of Herbal Preparations 49

Anton Biber

Friedrich Lang

Chapter 6. "Borrowed Science" and "Phytoequivalence":

Can Two Herbal Products Be Judged Equivalent? 59

Marilyn Barrett

Chemical or Pharmaceutical Equivalency 61

62

Application of the Concepts, Ginkgo As an Example 63

Meta-Analyses 65

Perspective 66

Chapter 7. Determining Efficacy of Herbal Preparations 69

Tieraona Low Dog

Observational Medicine 70

"Evidence-Based" Medicine 71

Summary 74

Chapter 8. Evaluating Safety of Herbal Preparations 77

Ezra Béjar

Joseph M. Betz

Marilyn Barrett

Evaluation of Safety 78

Adverse Reactions 80

Adverse-Event Reporting Systems 81

Categorization According to the Degree of Safety 82

Product Quality As an Aspect of Safety 84

Contraindications 85

Drug-Herb Interactions 85

Improving Our Knowledge of Safety 87

Chapter 9. Conducting Clinical Trials on Herbal Dietary

Supplements in North America: Commercialization,

Confidence, and Conflicts 91

Anthony L. Almada

The Spirit to Sponsor: Is There an Adequate Economic

Incentive to Fund Research? 92

Extracting Value from Science 95

Competitor Kevlar: Preventing Piracy of Product-Specific

Data 96

How Much Data Is Enough? 100

We Have Data--Now What? 103

Who Has Science and How Did They Acquire It? 105

Conclusion 105

Chapter 10. Motives for Conducting Clinical Trials

on Botanicals in Europe: A Focus on Germany 107

Joerg Gruenwald

Stefan Spiess

Chapter 11. Pharmacopoeias and Botanical Monographs 115

Marilyn Barrett

Roy Upton

V. Srini Srinivasan

United States Pharmacopeia and National Formulary

(USP-NF) 116

American Herbal Pharmacopoeia (AHP) and Therapeutic

Compendium 118

European Pharmacopoeia (EP) 119

British Herbal Pharmacopoeia (BHP) and British Herbal

Compendium (BHC) 119

German Commission E 120

European Scientific Cooperative on Phytotherapy (ESCOP) 121

Chinese Pharmacopoeia 121

African Pharmacopoeia 122

The Pharmacopoeia of Japan 122

The Pharmacopoeias of India 123

World Health Organization (WHO) 123

Other Pharmacopoeias 124

Summary and Perspective 124

Sources of Pharmacopoeias 125

PART II: METHODS

Chapter 12. Methods of Product and Trial Inclusion

and Evaluation 129

Marilyn Barrett

Gathering Information on Products and Trials 129

Data on Products and Trials 134

Evaluation of Clinical Trial Quality 137

Chapter 13. Clinical Trial Reviewer's Guidance

and Checklist 141

Tieraona Low Dog

Levels of Evidence 141

Guidelines for Reviewer Checklist: Part I 142

Guidelines for Reviewer Checklist: Part II 144

Scoring 146

PART III: BOTANICAL PROFILES--

PRODUCT AND CLINICAL TRIAL INFORMATION

(Artichoke-Ginseng)

Single Herbs 151

Artichoke 151

Preparations Used in Reviewed Clinical Studies 151

Artichoke Summary Table 152

Summary of Reviewed Clinical Studies 153

Postmarketing Surveillance Studies 154

Adverse Reactions or Side Effects 154

Information from Pharmacopoeial Monographs 155

Details on Artichoke Products and Clinical Studies 157

Bilberry 163

Preparations Used in Reviewed Clinical Studies 163

Bilberry Summary Table 164

Adverse Reactions or Side Effects 167

Information from Pharmacopoeial Monographs 168

Details on Bilberry Products and Clinical Studies 171

Black Cohosh 185

Preparations Used in Reviewed Clinical Studies 185

Black Cohosh Summary Table 186

Summary of Reviewed Clinical Studies 187

Postmarketing Surveillance Studies 189

Adverse Reactions or Side Effects 189

Information from Pharmacopoeial Monographs 190

Details on Black Cohosh Products and Clinical Studies 194

Boxwood 207

Preparations Used in Reviewed Clinical Studies 207

Summary of Reviewed Clinical Studies 207

Boxwood Summary Table 208

Adverse Reactions or Side Effects 209

Details on Boxwood Products and Clinical Studies 210

Butterbur, Purple 213

Preparations Used in Reviewed Clinical Studies 213

Butterbur Summary Table 214

Summary of Reviewed Clinical Studies 215

Adverse Reactions or Side Effects 216

Information from Pharmacopoeial Monographs 216

Details on Butterbur Products and Clinical Studies 218

Cat's Claw 225

Preparations Used in Reviewed Clinical Studies 225

Cat's Claw Summary Table 226

Summary of Reviewed Clinical Studies 227

Adverse Reactions or Side Effects 227

Details on Cat's Claw Products and Clinical Studies 228

Chaste Tree 231

Preparations Used in Reviewed Clinical Studies 231

Chaste Tree Summary Table 232

Summary of Reviewed Clinical Studies 233

Postmarketing Surveillance Studies 235

Adverse Reactions or Side Effects 236

Information from Pharmacopoeial Monographs 236

Details on Chaste Tree Products and Clinical Studies 240

Cordyceps 255

Preparations Used in Reviewed Clinical Studies 255

Summary of Reviewed Clinical Studies 255

Cordyceps Summary Table 256

Adverse Reactions or Side Effects 258

Information from Pharmacopoeial Monographs 258

Details on Cordyceps Products and Clinical Studies 260

Cranberry 265

Preparations Used in Reviewed Clinical Studies 265

Summary of Reviewed Clinical Studies 265

Cranberry Summary Table 266

Adverse Reactions or Side Effects 267

Information from Pharmacopoeial Monographs 268

Details on Cranberry Products and Clinical Studies 270

Devil's Claw 277

Preparations Used in Reviewed Clinical Studies 277

Summary of Reviewed Clinical Studies 277

Devil's Claw Summary Table 278

Adverse Reactions or Side Effects 280

Information from Pharmacopoeial Monographs 280

Details on Devil's Claw Products and Clinical Studies 283

Dragon's Blood Croton 291

Preparations Used in Reviewed Clinical Studies 291

Dragon's Blood Croton Summary Table 292

Summary of Reviewed Clinical Studies 293

Adverse Reactions or Side Effects 293

Details on Dragon's Blood Products and Clinical Studies 295

Echinacea 303

Preparations Used in Reviewed Clinical Studies 303

Echinacea Summary Table 304

Summary of Reviewed Clinical Studies 307

Reviews and Meta-Analyses of Clinical Studies 311

Adverse Reactions or Side Effects 312

Information from Pharmacopoeial Monographs 313

Details on Echinacea Products and Clinical Studies 321

Elderberry 351

Preparations Used in Reviewed Clinical Studies 351

Elderberry Summary Table 352

Summary of Reviewed Clinical Studies 353

Adverse Reactions or Side Effects 353

Information from Pharmacopoeial Monographs 353

Details on Elderberry Products and Clinical Studies 356

Evening Primrose 359

Preparations Used in Reviewed Clinical Studies 359

Evening Primrose Summary Table 360

Summary of Reviewed Clinical Studies 362

Systematic Reviews and Meta-Analyses 367

Adverse Reactions or Side Effects 368

Details on Evening Primrose Products and Clinical Studies 370

Garlic 403

Preparations Used in Reviewed... Read more ›
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