Customer Reviews

Handbook of Derivatization Reactions for HPLC

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Those who have been involved in chromatography for some timewill likely remember the book by Daniel Knapp, Handbook of AnalyticalDerivitization . This book is an excellent resource for exploring derivitazation reactions by GC, GC-MS and HPLC. The focus on this current volume is on HPLC and CE so those interested in GC and GC-MS should continue to refer to Knapp's book on this subject. This book by Lunn and Hellwig is an excellent addition to the literature. It is almost 1800 pages long with several appendixes including one on reagent types, formula names including a citation in the book where the particular reagent or chemical was used. There is also an appendix "Bibliography of Related References " that includes information on compound types not included in the main text. All of the appendixes are welcome additions to the book. The book is organized according to the functional group that is derivatized starting with acyl halide and ending with thiosulfate. Each entry includes the chemical structure involved in the reaction, the sample matrix, analyte, sample preparation, HPLC variables, chromatogram, key word (s) and reference(s). Additionally, should the sample be able to be analyzed by CE, that information is also provided. This books contains a wealth of information and reflects the heroic amount of work that has gone into it's preparation. In the introductory material, the authors provide the sources they used for searching the literature and indicate that the period searched was from 1978- present. A list of abbreviations and suppliers of reagents is also provided. In addition to the printed book, a searchable CD is also included. The CD provides similar information to that found in the book with search strategies straightforward and easy to execute. The entire package is excellent and highly recommended for it's breadth of coverage on this topic. This package should be available to all who are involved in this type of work.