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Handbook of Toxicogenomics: A Strategic View of Current Research and Applications [Hardcover]

J?rgen Borlak (Editor)


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Book Description

March 28, 2005 3527303421 978-3527303427 1
Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies.

The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives.

Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."


Editorial Reviews

Review

"…one of the few volumes that provide an overview of a field that will increasingly impact us in our daily work, and to which pathologists have a great deal to contribute." (Veterinary Pathology, November 2005)

"In summary, the handbook is written by many of the leaders in the field and provides a comprehensive overview of the interdisciplinary field of toxicogenomics.... both skilled practitioners and those new to the field will find something worthwhile and interesting in this comprehensive handbook." (ChemBioChem)

Review

"I would like to congratulate you on the publication of your Handbook, which deals with a hot topic. You have succeeded in acquiring leading representatives of this field as authors. The Handbook shows in a fascinating manner how modern genome research is leading to rapid progress and new discoveries in the area of toxicology."
--Professor Walter Rosenthal, Director, Forschungsinstitut für Molekulare Pharmakologie

Product Details

  • Hardcover: 705 pages
  • Publisher: Wiley-VCH; 1 edition (March 28, 2005)
  • Language: English
  • ISBN-10: 3527303421
  • ISBN-13: 978-3527303427
  • Product Dimensions: 9.7 x 7 x 1.6 inches
  • Shipping Weight: 3.2 pounds
  • Amazon Best Sellers Rank: #2,418,269 in Books (See Top 100 in Books)

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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
oligo arrays, teratogenicity studies, cardiovascular toxicity, avg score, toxicogenomic approaches, toxicology research, protein modification analysis, core similarity score, toxicogenomic analysis, hepatic liability, circadian gene regulation, hepatocyte nuclear factor network, using toxicogenomics, functional hits, endocrine disruption research, deregulated genes, toxicogenomics experiments, bridging biomarkers, high density gene expression profiling, benzene inhalation, toxicogenomics data, changed transcripts, integrative modelling, acid glycoprotein gene, toxicogenomic research
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Toxicogenomics Applied, Nucleic Acids Res, Biol Chem, Mol Cell Biol, Cancer Res, Jurgen Borlak Copyright, Handbook of Toxicogenomics, Mass Spectrom, Proc Natl Acad Sci, Regulatory Networks of Liver-enriched Transcription Factors, Toxicol Sci, The Chemical Effects, Systems Biology Applied, Genetic Variability, Covalent Protein Modification Analysis, New York, Nat Genet, Genes Dev, Toxicol Appl Pharmacol, Toxicogenomic Analysis of Human Umbilical Cords, Profiling of Peripheral Blood Gene Expression, Mol Biol, Health Perspect, Biochem Biophys Res Commun, Investigating the Effective Range of Agents
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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