A collection of readily reproducible experimental and clinical techniques for studying the molecular basis of hemoglobin disorders. These step-by-step methods utilize a wide variety of the latest analytical techniques, including x-ray crystallography, high performance liquid chromatography, electrophoresis, and nuclear magnetic resonance. Additional methods are offered for prenatal diagnostic analysis, the DNA diagnosis of hemoglobin mutations, hemoglobin fluorescence, and the semisynthesis of hemoglobin.
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"...the book is a very good practical volume for those interested in further clinical and experimental studies of hemoglobin disorders." - Biomedical Chromatography
From the Back Cover
The recent announcement that sickle-cell anemia and thalassemia have been corrected by the transplantation of stem cells bodes well for the future of gene therapy in hemoglobinopathies. In Hemoglobin Disorders: Molecular Methods and Protocols, Ronald Nagel, MD, has assembled a collection of readily reproducible techniques essential to the continued advance of our molecular understanding of these diseases. The book's richly experienced authors detail methods utilizing a wide variety of the latest analytical techniques, including X-ray crystallography, high performance liquid chromatography, electrophoresis, and nuclear magnetic resonance. Additional methods are offered for prenatal diagnostic analysis, the DNA diagnosis of hemoglobin mutations, hemoglobin fluorescence, and the semisynthesis of hemoglobin. Each protocol includes an introduction explaining the basic science, step-by-step instructions for its successful execution, notes on pitfalls to avoid, and tips on how to employ it effectively with novel systems and conditions. State-of-the-art and highly practical, Hemoglobin Disorders: Molecular Methods and Protocols reviews all the basic topics and techniques in this critically important field, and offers today's most comprehensive set of proven protocols for successful experimental and clinical work on hemoglobin diseases.
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Inside This Book
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First Sentence:
X-ray crystallography has played a key role in understanding the relationship between protein structure and physiological function. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
sickle polymer, hemin dicyanide, protein purification system, red cell density, gene cluster haplotypes, deoxygenation curve, human globin chains, concentrated phosphate buffer, unicentric origin, complete photolysis, stoppered glass jar, precipitant solution, sickle mutation, hemoglobin disorders, crystallizing solution, red cell suspensions, sickle gene, mouse globins, human globin genes, dithionite solution, oxygen equilibrium curves, sickle cell anemia patients, complementary segments, low oxygen affinity, vacutainer tubes Key Phrases - Capitalized Phrases (CAPs): (learn more)
Fast Flow, New York, Amersham Pharmacia Biotech, Molecular Medicine, Humana Press Inc, Q-Sepharose High Performance, Methods Enzymol, Hemoglobin Fluorescence, Acta Crystallogr, None None, Solubility of Sickle Polymer, X-ray Crystallography of Hemoglobins, Diagnosis of Hb Mutations, Analysis of Prenatal Diagnosis, Cambridge University Press, Hampton Research, National Institutes of Health, Protein Chem, Acids Res, Analysis of Hbs, Blood Cells Mol, Disorders of Hemoglobin, Hirsch Fig, San Diego, Becton Dickinson New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
X-ray crystallography has played a key role in understanding the relationship between protein structure and physiological function. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
sickle polymer, hemin dicyanide, protein purification system, red cell density, gene cluster haplotypes, deoxygenation curve, human globin chains, concentrated phosphate buffer, unicentric origin, complete photolysis, stoppered glass jar, precipitant solution, sickle mutation, hemoglobin disorders, crystallizing solution, red cell suspensions, sickle gene, mouse globins, human globin genes, dithionite solution, oxygen equilibrium curves, sickle cell anemia patients, complementary segments, low oxygen affinity, vacutainer tubes Key Phrases - Capitalized Phrases (CAPs): (learn more)
Fast Flow, New York, Amersham Pharmacia Biotech, Molecular Medicine, Humana Press Inc, Q-Sepharose High Performance, Methods Enzymol, Hemoglobin Fluorescence, Acta Crystallogr, None None, Solubility of Sickle Polymer, X-ray Crystallography of Hemoglobins, Diagnosis of Hb Mutations, Analysis of Prenatal Diagnosis, Cambridge University Press, Hampton Research, National Institutes of Health, Protein Chem, Acids Res, Analysis of Hbs, Blood Cells Mol, Disorders of Hemoglobin, Hirsch Fig, San Diego, Becton Dickinson New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 34
books:
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14
books
cite this book:
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- The Chromatography of Hemoglobin (Clinical and Biochemical Analysis Series) by Walter Adolph Schroeder on page 154, and page 176
- The Porphyrin Handbook, Volumes 1-10 by Karl Kadish on page 268
- Fetal Medicine: Basic Science and Clinical Practice by Charles H. Rodeck MB BS BSc DSc FRCOG FRCPath FMedSci on page 130
- Blood Substitutes (Winslow, Blood Substitutes) by Robert M. Winslow on page 47
- The Nuclear Overhauser Effect by D. Neuhaus on page 268
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- Suicide Gene Therapy: Methods and Reviews (Methods in Molecular Medicine) by Caroline J. Springer in Front Matter
- Cartilage and Osteoarthritis (Methods in Molecular Medicine) by Frédéric De Ceuninck in Front Matter
- Novel Anticancer Drug Protocols (Methods in Molecular Medicine) by John K. Buolamwini in Front Matter
- Blood'Brain Barrier: Biology and Research Protocols (Methods in Molecular Medicine) by Sukriti Nag in Front Matter
- Drugs of Abuse: Neurological Reviews and Protocols (Methods in Molecular Medicine) by John Q. Wang in Front Matter
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