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High-Throughput Screening in Drug Discovery (Methods and Principles in Medicinal Chemistry)
 
 
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High-Throughput Screening in Drug Discovery (Methods and Principles in Medicinal Chemistry) [Hardcover]

Jörg Hüser (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)

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Book Description

3527312838 978-3527312832 December 18, 2006 1
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results.

For both academics and professionals in the pharma and biotech industries working on small molecule screening.


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From the Back Cover

In present-day drug discovery, bioactive molecules with a sought-after physiological effect are identified by screening large libraries of drug candidates for a quantifiable effect on a biological target. Because of the large number of candidate molecules involved, screening assays with high compound throughput have been developed that yield high-quality results in a short time.

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results.

For both academics and professionals in the pharmaceutical and biotech industries working on small molecule screening.

About the Author

Dr. Jörg Hüser Director of HTS Technologies at the Healthcare Division of Bayer AG in Wuppertal (Germany).

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First Sentence:
Understanding cellular pathways and their molecular mechanisms is one of the longstanding goals of scientific research. Read the first page
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