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Prior to the 1980s, the discovery of a marketable bioactive molecule relied upon a company's ability to structurally modify known active molecules to yield a candidate with an improved activity profile.
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Key Phrases - Statistically Improbable Phrases (SIPs):
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test substance quantities, natural products acquisition programs, natural products acquisitions, high throughput screening group, lead discovery group, third combinatorial step, information handling requirements, first combinatorial step, marine organism samples, assay registration, second combinatorial step, radioactive screen, organism tissue samples, natural product samples, source actinomycetes, automation provider, screening scientists, robotic sample processors, screening infrastructure, neurotrophin concentration, pipetting workstation, benchtop systems, cyclic dinucleotides, interim database, sample automation
Key Phrases - Capitalized Phrases (CAPs):
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Contracting Party, Conference of the Parties, New York, Packard Instrument Company, National Cancer Institute, Academic Press, San Diego, Visual Basic, International Symposium, Discovery Systems, Plenum Press, White Point, Costa Rica, Zymark Corporation, Beckman Instruments, Biomedical Importance of Marine Organisms, California Academy of Sciences, Compound Sourcing, Med Chem, New Jersey, Optical Biosensor, Perkin Elmer, Second International Marine Biotechnology Conference, Chemically Generated Screening Libraries, Climate Change Convention
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