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Human Drug Metabolism: An Introduction Paperback – November 18, 2005

ISBN-13: 978-0470863534 ISBN-10: 0470863536 Edition: 1st

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Editorial Reviews

Review

"…a useful introductory text for the intended audience of students studying pharmacology and toxicology…" (Veterinary Pathology, November 2006)

"The author has certainly achieved his goal of providing an accessible introduction to human drug metabolism." (The Annals of Pharmacotherapy, June 2006)

" … for many who are just beginning to learn about drug metabolism because it deals with all of the relevant aspects." (Journal of Medicinal Chemistry, Vol. 49, No. 8, May 2006)

"Armed with the knowledge contained in this book, we should all be well on the way" (Pharmaceutical Physician,  May 2006)

"…useful for many who are just beginning to learn about drug metabolism…a good addition to many personal and school libraries." (Journal of Medicinal Chemistry, April 20, 2006)

"...thumbs up for ambition." (Chemistry World, 1st March 2006) 

"Overall this is an interesting book that provides a rather comprehensive overview of drug metabolism in humans" (Journal of Medicinal Chemistry,  2006 Volume 49. No 8)

From the Back Cover

Human Drug Metabolism: An Introduction provides an accessible introduction to human drug metabolism for those who already have some understanding of the life sciences. It focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare.

After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolising systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

  • focuses on a conceptual understanding of drug metabolism
  • takes a user-friendly approach to the chemical aspect of drug metabolism
  • includes a wealth of diagrams and illustrations
  • provides strategies for maximising examination performance

Human Drug Metabolism: An Introduction will be an invaluable resource for students studying pharmacology, pharmacy, bio-molecular sciences, biochemistry, molecular biology, toxicology, dentistry and medicine in addition to healthcare professionals and postgraduates.

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Product Details

  • Paperback: 286 pages
  • Publisher: Wiley; 1 edition (November 18, 2005)
  • Language: English
  • ISBN-10: 0470863536
  • ISBN-13: 978-0470863534
  • Product Dimensions: 6.6 x 0.6 x 9.6 inches
  • Shipping Weight: 1.2 pounds
  • Average Customer Review: 3.0 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Best Sellers Rank: #3,161,326 in Books (See Top 100 in Books)

More About the Author

Born 1960 in Crosby, near Liverpool (UK), some of Michael Coleman's earliest external influences included Liverpool's music scene and American cars of the late 1960's. Although he moved to the US in the late 1980's and owned a yellow V8 Dodge, which he spent some time rodding up and still misses, as he gave it to his friend who SOLD IT!! to someone else...When he returned to the UK he started driving Volvo's as he was sick of his earlier British cars disintegrating under him. Whilst he admires the engineering and reliability of Volvos and now knows a great deal about them, he sorely misses his beloved Dodge. He would really like a '68 Charger which he considers to be the zenith of the motoring world and is unsurpassed for sheer soul-churning beauty and sound. He sometimes watches the famous 9 min sequence in 'Bullitt' with tears in his eyes..you know the one. He sat in a '68 in 1988, but the guy mentioned he had sold it already to a 'dude with a GTO, but if you got more dough man, we can deal'. Michael's sense of fair play prevented him from accepting this offer. Although he can afford it now, he is basically too tight-fisted to buy a sixties Caddy, which would the the next best thing to a Charger. It's highly likely that his wife would give him a very hard time if he bought such a car also, but hey, whaddyagonna do? His music career in slide and blues guitar has so far resolutely failed to emerge from Marianas Trench levels of obscurity. Although technically capable and he has a deep love of the blues, he lacks the inspiration to write memorable songs. Michael has been particularly struck at the supernatural power of some songs to retrieve dying gigs ('No Particular Place to Go' and Pinball Wizard') so as he is unable to approach such towering genius, he will have to stick with his day job, which is science. This is just as well, as although he gave up drinking and smoking some time ago, he would probably mis-behave conspicuously on tour, disgrace himself comprehensively and probably end up like Nicky Sixx...or worse. Michael retains a profound admiration for the works of the first incarnation of Van Halen, as well as The Cult and has been a devoted student of Hendrix for more than 20 years. He is writing this biography to avoid the vast pile of marking obscuring his desk but is now resigned to having to finish the job-after all, somebody had to mark his virtually illegible stuff years ago. He also realises, that science, rather like our parents, gives us life and although we love it really and could not live without it, we don't always admit it.

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Most Helpful Customer Reviews

2 of 2 people found the following review helpful By Pharmacy professor on January 10, 2008
Format: Paperback
As an instructor of drug metabolism, I have read a lot of metabolism texts. This text is especially relevant for pharmacy students and medical students, but also for graduate students in some fields (pharmacology, human toxicology, human biochemistry). It focuses on its title, "human drug metabolism", and is written very clearly.

The author is British and occasionally overdoes the British professorial humor, yet it is the most readable and accessible (and still accurate and in-depth) text on the market! My pharmacy students actually read it, rather than using it as a paper weight.
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0 of 2 people found the following review helpful By chemist on December 3, 2007
Format: Paperback
I have never written a review before, but I was so disappointed that I decided to write this one. I found that material is presented in hard to understand format. Manuscript is supposed to be an introduction; however, it provides almost no background information related to biology, biochemistry or chemistry. Author lists numerous drugs, while providing hardly any information about their function or chemical structure. Quite complex phenomena are mentioned in one sentence, while author devotes half of the paragraph contemplating why students would find this information difficult.
Although I can't claim an expertise in writing, I rarely have been so annoyed by the writing style and the lack of content of the scientific text.
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